Article
Biochemistry & Molecular Biology
Jixiao Zhu, Manqin Fu, Jian Gao, Guoyu Dai, Qiunong Guan, Caigan Du
Summary: Flavan-3-ols, such as catechin, can prevent hypoxia-induced cell death in renal tubular epithelial cells by maintaining the expression of TXNRD1. Increasing TXNRD1 expression or activity may be a novel therapeutic strategy to prevent hypoxia-induced kidney damage.
Article
Medicine, Research & Experimental
Julia Yago-Ibanez, Laura Munoz-Moreno, Beatriz Gallego-Tamayo, Francisco Javier Lucio-Cazana, Ana Belen Fernandez-Martinez
Summary: Inflammatory cytokines contribute to proximal tubular cell injury, and PGE2 re-uptake by PGT is critical for PGE2-mediated injury. This study investigates the effects of pro-inflammatory cytokines in PTC and their prevention by PGT targeting.
Article
Medicine, Research & Experimental
Momoka Yamaguchi, Naoki Dohi, Akira Ooka, Shin-ya Saito, Tomohisa Ishikawa
Summary: The study revealed that the combination of prostaglandin E2 (PGE2) and caffeine effectively inhibits the activation of hepatic stellate cells (HSCs) during inflammation, suggesting a potential therapeutic strategy for suppressing liver fibrosis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Physiology
Ping Jia, Sujuan Xu, Xiaoyan Wang, Xiaoli Wu, Ting Ren, Zhouping Zou, Qi Zeng, Bo Shen, Xiaoqiang Ding
Summary: This study provides a mechanistic insight into how C-C motif chemokine ligand 2 (CCL2) is upregulated in renal tubular epithelial cells (TECs) and contributes to kidney dysfunction during sepsis. The data reveal that lipopolysaccharide induces CCL2 expression through the Toll-like receptor 2/NF-KB signaling pathway in TECs. Endogenous CCL2 released from TECs, not from myeloid cells, is responsible for sepsis-induced kidney inflammation and acute kidney injury.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mei-Chuan Kuo, Wei-An Chang, Ling-Yu Wu, Yi-Chun Tsai, Ya-Ling Hsu
Summary: Hypoxia-induced epithelial-to-mesenchymal transition (EMT) in proximal tubular epithelial cells (PTECs) is modulated by miR-545-3p-TNFSF10 interaction. TNFSF10 attenuates EMT induced by hypoxia in PTECs. These findings provide new insights into the unique regulation of miR-545-3p-TNFSF10 interaction and their potential therapeutic effect in kidney injury induced by hypoxia.
Article
Cell Biology
Muhammad Ali Khan, Purba Nag, Anca Grivei, Kurt T. K. Giuliani, Xiangju Wang, Vishal Diwan, Wendy Hoy, Helen Healy, Glenda Gobe, Andrew J. Kassianos
Summary: The pathogenesis of crystal nephropathy involves deposition of intratubular crystals, tubular obstruction and cell death. This study investigated the modes of adenine-induced tubular cell death and found that baicalein can act as a novel cell death inhibitor. Baicalein inhibits cell death by modulating the mitochondrial antioxidant enzyme SOD2.
CELL DEATH & DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Jongkwon Park, Yun Jung Heo, Soonjo Kwon
Summary: This study investigated the interaction between proximal tubular epithelial cells and hepatocytes under hypoxia using a transwell plate model. Results showed increased lactate dehydrogenase release in co-cultures, suggesting potential lipotoxicity effects between the two cell types.
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Lisa Z. Fang, Victoria Linehan, Maria Licursi, Christian O. Alberto, Jacob L. Power, Matthew P. Parsons, Michiru Hirasawa
Summary: Hypothalamic inflammation can exacerbate obesity and fatty liver by stimulating appetite-promoting neurons.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Janin Henkel, Julia Klauder, Meike Statz, Anne-Sophie Wohlenberg, Sonja Kuipers, Madita Vahrenbrink, Gerhard Paul Pueschel
Summary: The study found that a mix of palmitate, insulin, and PGE(2) in dysfunctional adipose tissue can induce the production of the pro-inflammatory cytokine IL-8. Insulin and PGE(2) amplify the effect of palmitate on IL-8 induction, exacerbating inflammation and insulin resistance.
Article
Multidisciplinary Sciences
Nawel Zaibi, Pengyun Li, Shang-Zhong Xu
Summary: The new class of glucose-lowering agents, SGLT-2 inhibitors, such as dapagliflozin, have shown protective effects against cell proliferation and cell death under oxidative stress conditions by reducing ROS production and altering Ca2+ dynamics.
Article
Multidisciplinary Sciences
Noriko Uehara-Watanabe, Natsuko Okuno-Ozeki, Itaru Nakamura, Tomohiro Nakata, Kunihiro Nakai, Aya Yagi-Tomita, Tomoharu Ida, Noriyuki Yamashita, Michitsugu Kamezaki, Yuhei Kirita, Satoaki Matoba, Keiichi Tamagaki, Tetsuro Kusaba
Summary: Based on recent clinical trials, the use of SGLT2 inhibitors has shown significant improvement in the outcomes of diabetic kidney disease (DKD), highlighting a shift in understanding the pathophysiology of DKD from a focus on glomeruli to tubules. This study investigates the changes in gene expression specific to the proximal tubules in diabetic mice treated with dapagliflozin, revealing downregulation of oxidative phosphorylation. Furthermore, treatment with dapagliflozin ameliorated the depletion of ATP content and renal tissue hypoxia in diabetic mice. These findings suggest that dapagliflozin may have renoprotective effects by reducing excessive oxygen and ATP consumption in the diabetic kidney.
Article
Immunology
Yang Chen, Hui-Yi Li, Jian-Shu Liu, Dao-long Jiang, Hao-nan Zheng, Xue-Song Dong
Summary: In this study, a diquat-induced human kidney-2 cells (HK-2 cells) apoptosis model was established and differentially expressed miRNAs and signaling pathways involved in diquat poisoning were identified through gene sequencing and bioinformatics analysis. The findings contribute to understanding the mechanisms of diquat poisoning and provide new targets for gene therapy of related diseases.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Neurosciences
Hiroshi Nango, Komugi Tsuruta, Hiroko Miyagishi, Yuri Aono, Tadashi Saigusa, Yasuhiro Kosuge
Summary: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by degeneration of motor neurons and inflammation of the spinal cord. Prostaglandin E-2 (PGE(2)) plays a role in the pathogenesis of ALS and its levels are elevated in ALS patients and model mice. Inhibiting the biosynthesis of PGE(2) has shown therapeutic potential in ALS model mice, but its clinical usefulness is yet to be proven. Understanding the role of PGE(2) in neurodegeneration may lead to the development of novel ALS therapies.
TRANSLATIONAL NEURODEGENERATION
(2023)
Article
Geriatrics & Gerontology
Xiaolin Li, Tosca Holtrop, Fleur A. C. Jansen, Brennan Olson, Pete Levasseur, Xinxia Zhu, Mieke Poland, Winni Schalwijk, Renger F. Witkamp, Daniel L. Marks, Klaske van Norren
Summary: Cachexia-anorexia syndrome is characterized by skeletal muscle wasting, reduced food intake, and systemic inflammation. This study investigated gut barrier function in pancreatic cancer-induced cachexia mouse models, revealing a link between intestinal permeability and cachexia severity. Tumour-derived PGE2 may play a key role in cancer-related cachexia-anorexia syndrome through tumour-gut-brain crosstalk.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Medicine, General & Internal
Zhiyin Pei, Meng Wu, Hanqing Yu, Guangfeng Long, Zhen Gui, Xiaonan Li, Hongbing Chen, Zhanjun Jia, Weiwei Xia
Summary: This study found that ISL, a compound found in licorice, has a protective effect and can alleviate cisplatin-induced kidney injury. ISL exerts its effect by antagonizing apoptosis, oxidative stress, and inflammation.
FRONTIERS IN MEDICINE
(2022)
Article
Surgery
Barbara Perez-Kohler, Selma Benito-Martinez, Francisca Garcia-Moreno, Marta Rodriguez, Gemma Pascual, Juan Manuel Bellon
Summary: The study investigated the use of cyanoacrylate tissue adhesive to improve mesh behavior at fixation zones. Results showed that cyanoacrylate prevented bacterial adhesion, reducing infections and optimizing the efficacy of antibacterial meshes compared to those fixed with sutures.
Article
Surgery
Gemma Pascual, Selma Benito-Martinez, Marta Rodriguez, Barbara Perez-Kohler, Francisca Garcia-Moreno, Juan M. Bellon
Summary: The behaviour of two composite materials, Phasix and Symbotex, at the peritoneal level during hernia repair was examined in a preclinical model. Phasix showed greater neoperitoneum thickness and higher expression of M2 macrophage markers related to tissue repair compared to Symbotex. The study concluded that fewer adhesions formed to Symbotex implants, yet Phasix had a stronger tissue repair response.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Multidisciplinary Sciences
Alberto Valdes, Francisco J. Lucio-Cazana, Maria Castro-Puyana, Coral Garcia-Pastor, Oliver Fiehn, Maria Luisa Marina
Summary: The study revealed that the combined exposure of high glucose and hypoxia significantly altered multiple metabolic pathways in HK-2 cells, including carbohydrate, pentose phosphate, arginine, and proline metabolism. Other affected metabolites were found in purine and lipid metabolism, as well as in protecting against osmotic stress and preventing the activation of the beta-oxidation pathway. Overall, the effects observed are consistent with previous in vivo studies.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Samuel Bernardo-Bermejo, Elena Sanchez-Lopez, Lei Tan, Selma Benito-Martinez, Zhengjin Jiang, Maria Castro-Puyana, Francisco Javier Lucio-Cazana, Maria Luisa Marina
Summary: Oxygen deficiency can disrupt biological functions and lead to diseases. Kidneys are particularly sensitive to hypoxia, which is linked to acute kidney injury and chronic kidney disease. Understanding hypoxia-induced metabolic alterations is crucial for kidney disease research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Urology & Nephrology
Jordi Bover, Ricardo Bosch, Jose Luis Gorriz, Pablo Urena, Alberto Ortiz, Iara daSilva, Ramon A. Garcia-Trabanino, Miguel Hueso, Pedro Trinidad, Aquiles Jara, Monica Furlano, Rosana Gelpi, Ana Vila-Santandreu, Cesar A. Restrepo, Maya Sanchez-Baya, Carolt Arana, Marian Goicoechea, Veronica Coll, Julian Segura, Orlando Gutierrez, Kamyar Kalantar-Zadeh, Emilio Sanchez, Alejandro Ferreiros, Rafael Garcia-Maset
Article
Biochemistry & Molecular Biology
Rafael Moreno-Gomez-Toledano, Maria Arenas, Carmen Munoz-Moreno, Nuria Olea-Herrero, Paula Reventun, Adriana Izquierdo-Lahuerta, Alba Anton-Cornejo, Marta Gonzalez-Santander, Carlos Zaragoza, Marta Saura, Ricardo J. Bosch
Summary: Research has shown that BPA exposure can lead to kidney alterations that resemble early diabetic nephropathy, such as increased kidney damage biomarkers, urinary albumin excretion, and hypertension. Additionally, male mice exposed to BPA exhibited more severe adverse effects, displaying a pattern of sexual dimorphism.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Surgery
Selma Benito-Martinez, Marta Rodriguez, Francisca Garcia-Moreno, Barbara Perez-Kohler, Estefania Pena, Begona Calvo, Gemma Pascual, Juan Manuel Bellon
Summary: This study compared the biological and mechanical behavior of two self-fixing meshes to that of a mesh fixed with tissue adhesive in a preclinical model of abdominal hernia repair in rabbits. The results showed that the self-fixing meshes exhibited better host tissue incorporation, macrophage response, and tensile strength compared to the adhesive mesh.
Article
Biochemistry & Molecular Biology
Selma Benito-Martinez, Barbara Perez-Kohler, Marta Rodriguez, Jesus Maria Izco, Jose Ignacio Recalde, Gemma Pascual
Summary: This preclinical study compared the effects of a new collagen-based hydrolysate powder to a commercial non-hydrolysate product on wound repair in a murine model. The findings indicate that the new collagen treatment can significantly accelerate wound closure and promote the reparative process.
Article
Medicine, Research & Experimental
Julia Yago-Ibanez, Laura Munoz-Moreno, Beatriz Gallego-Tamayo, Francisco Javier Lucio-Cazana, Ana Belen Fernandez-Martinez
Summary: Inflammatory cytokines contribute to proximal tubular cell injury, and PGE2 re-uptake by PGT is critical for PGE2-mediated injury. This study investigates the effects of pro-inflammatory cytokines in PTC and their prevention by PGT targeting.
Article
Psychology, Multidisciplinary
Pablo Polo, Nohelia T. Valenzuela, Jose Antonio Munoz-Reyes, Irene Ruiz-Perez, Carlos Rodriguez-Sickert, Margarita Matellano, Ana B. Fernandez-Martinez, Miguel Pita
Summary: This study examines the impact of the androgen receptor (AR) gene CAG polymorphism on human mating strategies, finding no association between CAG polymorphism and mating strategies, but a link between self-perceived fighting ability and short-term mating orientation.
CURRENT PSYCHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Samuel Bernardo-Bermejo, Elena Sanchez-Lopez, Maria Castro-Puyana, Ana B. Fernandez-Martinez, Francisco Javier Lucio-Cazana, Maria Luisa Marina
Summary: Apoptotic bodies (ABs), a type of extracellular vesicles, play a significant role in the pathogenesis of various diseases. This study used a non-targeted metabolomic approach to investigate the impact of different apoptotic stimuli (cisplatin or UV light) on the metabolites involved in apoptosis propagation. The results revealed stimulus-specific differences in metabolite abundances, suggesting that these metabolites may vary in their contribution to apoptosis depending on the apoptotic stimulus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Agata Ramos-Torres, Edurne Avellanal-Zaballa, Fernando Garcia-Garrido, Ana B. Fernandez-Martinez, Alejandro Prieto-Castaneda, Antonia R. Agarrabeitia, Jorge Banuelos, Inmaculada Garcia-Moreno, Francisco-Javier Lucio-Cazana, Maria J. Ortiz
Summary: This article discusses the design of a new model based on a small neutral 8-aryl-3-formylBODIPY, which can be used to develop highly bright and photostable fluorescent probes for selective and covalent staining of mitochondria.
CHEMICAL COMMUNICATIONS
(2021)