Article
Business
Nathan Warren, Sara Hanson, Hong Yuan
Summary: The study finds that requesting tips before completing a service leads to smaller tips, reduced return intentions, diminished word-of-mouth intentions, and lower online ratings. Additionally, the psychological mechanism underlying the harmful effects of requesting a tip before service is identified.
JOURNAL OF SERVICE RESEARCH
(2021)
Editorial Material
Immunology
Emily R. Siniscalco, Joe Craft
Summary: Regulatory T cells produce IL-27 to restrain TH17 cell-mediated immune responses in the intestine, effectively limiting autoimmune inflammation and T cell responses to specific gut pathogens.
Review
Biochemistry & Molecular Biology
Evi B. Struble, Haruhiko Murata, Takashi Komatsu, Dorothy Scott
Summary: HCMV infection is widespread and can have severe consequences, but attempts to demonstrate the safety and efficacy of antibody products and vaccines in clinical trials have been largely unsuccessful so far. New developments and approaches are being highlighted to assist in successful translation of HCMV immunotherapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Yang Liu, Shuang Liang, Dandan Jiang, Tong Gao, Yuxiao Fang, Shunli Fu, Li Guan, Zipeng Zhang, Weiwei Mu, Qihui Chu, Yongjun Liu, Na Zhang
Summary: Manipulation of tumor-associated macrophages (TAMs) has been identified as a key factor in improving immunotherapies, with inhibition of the NF-kappa B pathway potentially impacting both PD-1/PD-L1 and NF-kappa B pathways simultaneously. Co-loading PD-1 antibody and NF-kappa B pathway inhibitor in nanocarriers has shown promising results in enhancing the efficacy of immunotherapies.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biology
Philipp Kolb, Katja Hoffmann, Annika Sievert, Henrike Reinhard, Eva Merce-Maldonado, Vu Thuy Khanh Le-Trilling, Anne Halenius, Dominique Guetle, Hartmut Hengel
Summary: HCMV uses multiple immune evasion strategies to counteract host immune control mechanisms, including the simultaneous expression of gp34 and gp68 to efficiently antagonize host FcγR activation through distinct but synergizing mechanisms. Gp34 enhances immune complex internalization, while gp68 inhibits host FcγR binding to immune complexes.
Review
Immunology
Mengtian Wan, Yuzhu Ding, Zheng Li, Xu Wang, Min Xu
Summary: This paper discusses metabolic reprogramming in tumor cells and the influence of metabolite by-products on the immune microenvironment, providing novel insights into tumor immunotherapy.
Article
Immunology
Lauren E. Higdon, Claire E. Gustafson, Xuhuai Ji, Malaya K. Sahoo, Benjamin A. Pinsky, Kenneth B. Margulies, Holden T. Maecker, Jorg Goronzy, Jonathan S. Maltzman
Summary: Immune function changes with age, and infection with CMV accelerates these changes, resulting in increased mortality and impaired responses in elderly individuals. Following organ transplantation, CMV+ recipients show accelerated aging of CD8 T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Lingyun Li, Mengzhen Li, Minxuan Wang, Limin Zhang, Yao Yu, Jiatao Zhang, Bing Ma, Weizhi Wang
Summary: This article introduces a click chemistry-driven protein sorting strategy that achieves spatial and temporal manipulation of specific proteins along the PD-1 immune checkpoint axis. The strategy shows promising results in tumor-immune therapy both in vitro and in vivo.
Review
Virology
Sara Becker, Annette Fink, Juergen Podlech, Matthias J. Reddehase, Niels A. Lemmermann
Summary: Cytomegaloviruses (CMVs) have evolved through private gene families to adapt to their specific mammalian hosts. The host immune response drives viral evolution and the acquisition of immune evasion proteins encoded by private gene families. The mouse model based on murine cytomegalovirus (mCMV) is a versatile tool for studying virus-host interplay. This review focuses on the immune evasion of CD8(+) T cells by mCMV proteins and their role during acute and latent infection.
Article
Biochemistry & Molecular Biology
Mebrahtu G. Tedla, Alison L. Every, Jean-Pierre Y. Scheerlinck
Summary: Schistosoma mansoni is able to escape the host's immunity, but this study shows that memory T cells can withstand its manipulation, suggesting the potential for vaccines to produce immune memory responses that can protect against S. mansoni infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychology, Multidisciplinary
Alberto Prati, Claudia Senik
Summary: The study reveals a systematic bias in people's recollection of past happiness, with most individuals tending to overstate their happiness and underestimate the level of happiness in the past. Happy individuals are more likely to perceive their life's progression as better than it actually was, while unhappy individuals tend to exaggerate the negative aspects of life's evolution.
PSYCHOLOGICAL SCIENCE
(2022)
Article
Psychology, Social
Anna-Leena Macey, Simo Jaervelae, Daniel Fernandez Galeote, Juho Hamari
Summary: Social performance situations, such as public speaking, are challenging across different cultures. Public speaking anxiety can impact job performance and opportunities. Virtual reality provides a safe space for individuals to practice public speaking and reduce stress.
CYBERPSYCHOLOGY BEHAVIOR AND SOCIAL NETWORKING
(2023)
Article
Virology
Franziska Rothemund, Myriam Scherer, Eva-Maria Schilling, Johannes Schweininger, Yves A. Muller, Thomas Stamminger
Summary: The study analyzed the functions of human cytomegalovirus (CMV) immediate early 1 (IE1) protein and rat CMV IE1 (rIE1) protein, and found that their interactions with cellular proteins PML and FEN1 were species-specific. It was also discovered that both IE1 proteins can antagonize human STAT2, but different regions of the viral proteins were involved in the interaction. Additionally, the study revealed that the binding of PML, FEN1, and STAT2 was conserved between primate and rodent proteins, but rIE1 lacked chromatin tethering function.
Article
Immunology
Elizabeth Hastie, Carlee Moser, Xin Sun, Jeffrey Lennox, Priscilla Y. Hsue, Ronald J. Bosch, Steven Deeks, Milenka Meneses, Michael M. Lederman, Peter Hunt, Timothy J. Henrich, Vincent C. Marconi, Sara Gianella
Summary: The immune-modulators ruxolitinib and sirolimus did not have a significant effect on CMV DNA shedding in people with HIV on suppressive antiretroviral therapy. However, higher CMV DNA levels were associated with immune markers related to HIV persistence and mortality rates. CMV is a known contributor to the persistent inflammation and immune dysfunction observed in HIV.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Jintao Xia, Xuejie Li, Genyong Gui, Jian Wu, Shengnan Gong, Yuxin Shang, Jun Fan
Summary: This study evaluated the early immune response of recipients with disparate HCMV outcomes and found that HCMV-specific IFN-gamma secreting cells, HCMV IgG, and absolute lymphocyte count could represent the humoral and cellular immune response. Early monitoring of these immune markers could enable prediction of HCMV outcomes posttransplant and assessment of the severity of HCMV DNAemia.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Susan J. Burke, Michael D. Karlstad, Kellie M. Regal, Tim E. Sparer, Danhong Lu, Carrie M. Elks, Ryan W. Grant, Jacqueline M. Stephens, David H. Burk, J. Jason Collier
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2015)
Article
Medicine, Legal
Kathleen A. Hauther, Kelly L. Cobaugh, Lee Meadows Jantz, Tim E. Sparer, Jennifer M. DeBruyn
JOURNAL OF FORENSIC SCIENCES
(2015)
Article
Immunology
Jinho Heo, Pranay Dogra, Tom J. Masi, Elisabeth A. Pitt, Petra de Kruijf, Martine J. Smit, Tim E. Sparer
JOURNAL OF IMMUNOLOGY
(2015)
Article
Multidisciplinary Sciences
Pranay Dogra, Emily B. Martin, Angela Williams, Raphael L. Richardson, James S. Foster, Nicole Hackenback, Stephen J. Kennel, Tim E. Sparer, Jonathan S. Wall
Article
Pharmacology & Pharmacy
Elisabeth A. Pitt, Pranay Dogra, Ravi S. Patel, Angela Williams, Jonathan S. Wall, Tim E. Sparer
ANTIVIRAL RESEARCH
(2016)
Article
Biotechnology & Applied Microbiology
Pranay Dogra, Mindy Miller-Kittrell, Elisabeth Pitt, Joseph W. Jackson, Tom Masi, Courtney Copeland, Shuen Wu, William Miller, Tim Sparer
JOURNAL OF GENERAL VIROLOGY
(2016)
Review
Endocrinology & Metabolism
J. Jason Collier, Tim E. Sparer, Michael D. Karlstad, Susan J. Burke
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2017)
Article
Immunology
Sarah E. Davis, Robert N. Tams, Norma Solis, Andrew S. Wagner, Tian Chen, Joseph W. Jackson, Sahar Hasim, Anthony E. Montedonico, Justin Dinsmore, Timothy E. Sparer, Scott G. Filler, Todd B. Reynolds
INFECTION AND IMMUNITY
(2018)
Article
Endocrinology & Metabolism
Susan J. Burke, Danhong Lu, Tim E. Sparer, Thomas Masi, Matthew R. Goff, Michael D. Karlstad, J. Jason Collier
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2014)
Article
Engineering, Biomedical
Jonathan Page, Benjamin A. Heitz, James R. Joubert, John P. Keogh, Tim Sparer, S. Scott Saavedra, Wei He
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2011)
Article
Biochemistry & Molecular Biology
Susan J. Burke, Danhong Lu, Tim E. Sparer, Michael D. Karlstad, J. Jason Collier
MOLECULAR IMMUNOLOGY
(2014)
Review
Virology
Joseph W. Jackson, Tim Sparer
Article
Genetics & Heredity
Tian Chen, Joseph W. Jackson, Robert N. Tams, Sarah E. Davis, Timothy E. Sparer, Todd B. Reynolds
Article
Microbiology
Joseph W. Jackson, Trevor J. Hancock, Pranay Dogra, Ravi Patel, Ravit Arav-Boger, Angela D. Williams, Stephen J. Kennel, Jonathan S. Wall, Tim E. Sparer
Article
Veterinary Sciences
William A. Hill, Jacquelyn T. Tubbs, Christopher L. Carter, Jane A. Czarra, Kimberly M. Newkirk, Tim E. Sparer, Barton Rohrbach, Christine M. Egger
JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
(2013)