Review
Agriculture, Dairy & Animal Science
Elin Jorgensen, Thomas Bjarnsholt, Stine Jacobsen
Summary: Delayed wound healing in equine limb wounds may be attributed to biofilm infections, which are difficult to detect with routine diagnostics. Treatment options include aggressive debridement and application of topical antimicrobial therapy. Biofilm presence in equine wounds requires advanced detection techniques for proper diagnosis and management.
Article
Veterinary Sciences
Elina Tukia, Isa Hallman, Maarit Penttilae, Satu Haenninen, Maria Kareskoski
Summary: Endometritis is a common cause of infertility in mares, often caused by bacteria such as E. coli and beta-haemolytic streptococci. This study aimed to detect the presence and localization of E. coli bacteria in equine endometrial biopsies using a chromogenic RNAscope method. However, no evidence of bacterial invasion was found, regardless of the inflammatory status or previous bacterial culture results. Further research is needed to investigate potential localized infections or biofilm coverings that may have led to undetected bacterial presence.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Microbiology
Clemence Loublier, Bernard Taminiau, Julia Heinen, Laureline Lecoq, Helene Amory, Georges Daube, Carla Cesarini
Summary: This in vitro study aimed to assess the effect of a commonly used pre-FMT processing method on the bacterial composition and viability of the fecal filtrate. The results showed that the major bacterial populations in equine feces remained viable when using the described pre-FMT protocol, but the relative abundances of some minor genera were significantly different in the final filtrate.
Review
Medicine, Research & Experimental
Aakansha Giri Goswami, Somprakas Basu, Tuhina Banerjee, Vijay Kumar Shukla
Summary: The biofilm, a community of microorganisms protected by a self-produced matrix, plays a vital role in infection and antimicrobial resistance. The formation, growth, and resistance mechanism of biofilm are still not fully understood. Although there have been studies on anti-biofilm and antimicrobial therapeutics, the lack of a clear clinical standard calls for the translation of laboratory research into novel bedside strategies. Biofilm is responsible for faulty wound healing and chronic wounds. Understanding its interaction with wounds and developing reproducible anti-biofilm measures in a clinical setting is the current challenge.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Editorial Material
Biochemistry & Molecular Biology
Catherine M. Phelps, Marlies Meisel
Summary: Changes in gut microbiota are linked to the development of complex diseases like multiple sclerosis. In this issue of Cell, the international Multiple Sclerosis Microbiome Study consortium utilized a multi-omics approach to investigate the composition and function of the gut microbiome in a large cohort of MS patients.
Article
Ecology
Olga Burtseva, Olga Baulina, Anna Zaytseva, Tatiana Fedorenko, Konstantin Chekanov, Elena Lobakova
Summary: Researchers reported the formation of biofilms in vitro by bioluminescent bacteria isolated from the intestines of marine fish, demonstrating their ability to aggregate and attach to solid surfaces. This discovery provides insights into the formation of microbial biofilms in the gastrointestinal tract and presents a foundation for further studies.
Article
Agriculture, Dairy & Animal Science
Axelle Collinet, Pauline Grimm, Emmanuel Jacotot, Veronique Julliand
Summary: This study investigated the use of blood and fecal biomarkers as non-invasive indicators of mucosal integrity loss and local inflammation associated with microbiota disturbances in the large intestine of horses. The results showed significant correlations between the biomarkers and bacterial variations in the feces, supporting the hypothesis of a relationship between microbiota disturbances and intestinal barrier disruption in horses.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Lulu Pei, Juanjuan Liu, Zonghao Huang, Mudassar Iqbal, Yaoqin Shen
Summary: The aim of this study was to evaluate the antibacterial potential of lactic acid bacteria isolated from healthy horses on Salmonella infection in mice models and their effects on intestinal flora. The results showed that lactic acid bacteria could alleviate Salmonella infection and regulate intestinal microbiota.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Agriculture, Dairy & Animal Science
Carolina Silva, Joao F. Requicha, Jose J. Martins, Aida Duarte, Isabel R. Dias, Carlos A. Viegas, Maria J. Saavedra
Summary: The study suggests that captive wild mammals could be potential sources of multidrug-resistant bacteria, proposing the establishment of local monitoring programs worldwide to protect human, animal, and environmental health.
Review
Biochemistry & Molecular Biology
Emerito Carlos Rodriguez-Merchan, Donald J. Davidson, Alexander D. Liddle
Summary: Biofilm-related implant infections are a disastrous complication of orthopaedic surgery, with high treatment risks, significant socioeconomic costs, and a high risk of recurrence. Interventions to prevent and treat these infections are a major focus of research due to the large number of medical device implantations performed annually.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Maider Ugalde-Arbizu, John Jairo Aguilera-Correa, Victoria Garcia-Almodovar, Karina Ovejero-Paredes, Diana Diaz-Garcia, Jaime Esteban, Paulina L. Paez, Sanjiv Prashar, Eider San Sebastian, Marco Filice, Santiago Gomez-Ruiz
Summary: Five different silica nanoparticles functionalized with vitamin B12, a derivative of coumarin found in green plants and a minimum content of an organotin(IV) fragment have been identified as excellent anticancer agents against triple negative breast cancer. Additionally, they also show effective antibacterial activity.
Article
Microbiology
Mei Li, Hong Xiao, Yongmei Su, Danlin Cheng, Yan Jia, Yingli Li, Qi Yin, Jieying Gao, Yong Tang, Qunhua Bai
Summary: Prevention and control of infections have become a formidable challenge due to the increasing resistance of pathogens to antibiotics. Probiotics have been discovered to have positive effects on the host, and it is well-known that some Lactobacilli are effective in treating and preventing inflammatory and infectious diseases. The study developed an antibacterial formulation consisting of honey and Lactobacillus plantarum. The formulation showed antimicrobial effects and mechanisms in vitro, as well as a healing effect on skin infections in rats.
Article
Urology & Nephrology
Glenn T. Werneburg, Ava Adler, Prajit Khooblall, Hadley M. Wood, Bradley C. Gill, Sarah C. Vij, Kenneth W. Angermeier, Scott D. Lundy, Aaron W. Miller, Petar Bajic
Summary: A study has shown that microbial biofilms are present on penile prosthesis devices whether or not there is an infection, and the composition of these biofilms is primarily influenced by the device manufacturer, individual variability, and infection status.
JOURNAL OF SEXUAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Gaofeng Wang, Zhen Lin, Yue Li, Lu Chen, Sashank K. Reddy, Zhiqi Hu, Luis Garza
Summary: With the development of society and the improvement of life quality, over 500 million people are affected by diabetes. More than 10% of diabetes patients suffer from diabetic wounds, and 80% of these wounds reoccur, highlighting the importance of developing new diabetic wound treatments. Skin microbe research has shed light on the complex relationship between microbes and diabetic wounds. Understanding the skin microbe composition in diabetic wounds can provide valuable guidance for clinical treatment and even lead to potential therapies.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Lei Feng, Zhenhao Tian, Ming Zhang, Xin He, Xiangge Tian, Zhenlong Yu, Xiaochi Ma, Chao Wang
Summary: A NIR fluorescent probe, DDAA, derived from fluorophore DDAO with alanine as the recognition group, was developed for sensing aminopeptidase N (APN) in gut microbiota. The probe successfully identified target bacteria and saccharomycete possessing active APN from human feces using real-time fluorescence imaging.
CHINESE CHEMICAL LETTERS
(2021)
Article
Biotechnology & Applied Microbiology
Agnieszka J. Turlo, Yalda Ashraf Kharaz, Peter D. Clegg, James Anderson, Mandy J. Peffers
Article
Orthopedics
Katie Joanna Lee, Peter David Clegg, Eithne Josephine Comerford, Elizabeth Gail Canty-Laird
BMC MUSCULOSKELETAL DISORDERS
(2018)
Review
Orthopedics
C. Wayne McIlwraith, Christopher E. Kawcak, David D. Frisbie, Christopher B. Little, Peter D. Clegg, Mandy J. Peffers, Morten A. Karsdal, Stina Ekman, Sheila Laverty, Richard A. Slayden, Linda J. Sandell, L. S. Lohmander, Virginia B. Kraus
JOURNAL OF ORTHOPAEDIC RESEARCH
(2018)
Article
Biochemical Research Methods
James R. Anderson, Marie M. Phelan, Peter D. Clegg, Mandy J. Peffers, Luis M. Rubio-Martinez
JOURNAL OF PROTEOME RESEARCH
(2018)
Article
Dermatology
Steven L. Percival, Rui Chen, Dieter Mayer, Anne-Marie Salisbury
INTERNATIONAL WOUND JOURNAL
(2018)
Article
Dermatology
Steven L. Percival, Matthew Malone, Dieter Mayer, Anne-Marie Salisbury, Gregory Schultz
INTERNATIONAL WOUND JOURNAL
(2018)
Article
Dermatology
Sharon D. Hunt, Fredrik Elg, Steven L. Percival
JOURNAL OF WOUND CARE
(2018)
Review
Microbiology
Steven L. Percival, Anne-Marie Salisbury, Rui Chen
CRITICAL REVIEWS IN MICROBIOLOGY
(2019)
Article
Dermatology
Steven L. Percival, Dieter Mayer, Robert S. Kirsner, Greg Schultz, Dot Weir, Sashwati Roy, Afsaneh Alavi, Marco Romanelli
INTERNATIONAL WOUND JOURNAL
(2019)
Article
Dermatology
Rui Chen, Anne-Marie Salisbury, Steven L. Percival
INTERNATIONAL WOUND JOURNAL
(2019)
Article
Dermatology
Anne-Marie Salisbury, Marc Mullin, Rui Chen, Steven L. Percival
ADVANCES IN WOUND CARE
(2019)
Article
Dermatology
Robert S. Kirsner, Rene Amaya, Kathryn Bass, Vita Boyar, Guido Ciprandi, Paul M. Glat, Steven L. Percival, Marco Romanelli, Timothy P. Pittinger
JOURNAL OF WOUND CARE
(2019)
Article
Dermatology
Rui Chen, Anne-Marie Salisbury, Steven L. Percival
INTERNATIONAL WOUND JOURNAL
(2020)
Review
Infectious Diseases
S. Schwarzer, G. A. James, D. Goeres, T. Bjarnsholt, K. Vickery, S. L. Percival, P. Stoodley, G. Schultz, S. O. Jensen, M. Malone
JOURNAL OF INFECTION
(2020)
Article
Surgery
Steven L. Percival
SURGICAL TECHNOLOGY INTERNATIONAL-INTERNATIONAL DEVELOPMENTS IN SURGERY AND SURGICAL RESEARCH
(2018)