Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer’s disease

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Pharmacological Selectivity Within Class I Histone Deacetylases Predicts Effects on Synaptic Function and Memory Rescue

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Phosphodiesterase Inhibitors as a Target for Cognition Enhancement in Aging and Alzheimer’s Disease: A Translational Overview

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Simulations suggest pharmacological methods for rescuing long-term potentiation

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Targeting histone-modifications in Alzheimer's disease. What is the evidence that this is a promising therapeutic avenue?

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The Potential of HDAC Inhibitors as Cognitive Enhancers

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HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila

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Phosphodiesterases as Therapeutic Targets for Alzheimer's Disease

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Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity

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Tadalafil crosses the blood–brain barrier and reverses cognitive dysfunction in a mouse model of AD

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Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease

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Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease

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CREB's control of intrinsic and synaptic plasticity: implications for CREB-dependent memory models

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Targeting the correct HDAC(s) to treat cognitive disorders

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HDAC2 negatively regulates memory formation and synaptic plasticity

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Phenylbutyrate Ameliorates Cognitive Deficit and Reduces Tau Pathology in an Alzheimer's Disease Mouse Model

(2009) Ana Ricobaraza et al.   NEUROPSYCHOPHARMACOLOGY

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

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Epigenetics, genomic mutations and cognitive function

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Distinct Pools of β-Amyloid in Alzheimer Disease–Affected Brain

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Histone deacetylase 6 interacts with the microtubule-associated protein tau

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Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

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