Cytotoxic and Antitumor Activity of Sulforaphane: The Role of Reactive Oxygen Species

ROS-induced epithelial-mesenchymal transition in mammary epithelial cells is mediated by NF-κB-dependent activation of Snail

(2015) Magdalena A. Cichon et al.   Oncotarget

Sulforaphane induces apoptosis in T24 human urinary bladder cancer cells through a reactive oxygen species-mediated mitochondrial pathway: The involvement of endoplasmic reticulum stress and the Nrf2 signaling pathway

(2014) GUK HEUI JO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Sulforaphane Induces DNA Damage and Mitotic Abnormalities in Human Osteosarcoma MG-63 Cells: Correlation with Cell Cycle Arrest and Apoptosis

(2014) José Miguel P. Ferreira de Oliveira et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Antileukemic Activity of Sulforaphane in Primary Blasts from Patients Affected by Myelo- and Lympho-Proliferative Disorders and in Hypoxic Conditions

(2014) Carmela Fimognari et al.   PLoS One

Sulforaphane-induced apoptosis involves p53 and p38 in melanoma cells

(2013) K. Rudolf et al.   APOPTOSIS

The broccoli-born isothiocyanate sulforaphane impairs nucleotide excision repair: XPA as one potential target

(2013) Ann Liza Piberger et al.   ARCHIVES OF TOXICOLOGY

Oxidative stress response elicited by mitochondrial dysfunction: Implication in the pathophysiology of aging

(2013) Chih-Hao Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Sulforaphane induces reactive oxygen species-mediated mitotic arrest and subsequent apoptosis in human bladder cancer 5637 cells

(2013) Hyun Soo Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Low concentrations of isothiocyanates protect mesenchymal stem cells from oxidative injuries, while high concentrations exacerbate DNA damage

(2012) Fulvia Zanichelli et al.   APOPTOSIS

Sulforaphane, a cruciferous vegetable-derived isothiocyanate, inhibits protein synthesis in human prostate cancer cells

(2012) Aleksandra Wiczk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Sulforaphane inhibits pancreatic cancer through disrupting Hsp90–p50Cdc37 complex and direct interactions with amino acids residues of Hsp90

(2012) Yanyan Li et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Sulforaphane synergistically enhances the cytotoxicity of arsenic trioxide in multiple myeloma cells via stress-mediated pathways

(2012) NICOLE A. DOUDICAN et al.   ONCOLOGY REPORTS

Dose-dependent effects of R-sulforaphane isothiocyanate on the biology of human mesenchymal stem cells, at dietary amounts, it promotes cell proliferation and reduces senescence and apoptosis, while at anti-cancer drug doses, it has a cytotoxic effect

(2011) Fulvia Zanichelli et al.   AGE

Cancer statistics, 2011

(2011) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Bioavailability of Sulforaphane from Two Broccoli Sprout Beverages: Results of a Short-term, Cross-over Clinical Trial in Qidong, China

(2011) P. A. Egner et al.   Cancer Prevention Research

Reactive oxygen species and PI3K/Akt signaling play key roles in the induction of Nrf2-driven heme oxygenase-1 expression in sulforaphane-treated human mesothelioma MSTO-211H cells

(2011) Yoon-Jin Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

Autophagy and cell death signaling following dietary sulforaphane act independently of each other and require oxidative stress in pancreatic cancer

(2011) Franco Fortunato   INTERNATIONAL JOURNAL OF ONCOLOGY

Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells

(2011) John D. Clarke et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Natural isothiocyanates: Genotoxic potential versus chemoprevention

(2011) Carmela Fimognari et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Mechanisms of 4-Hydroxy-2-nonenal Induced Pro- and Anti-Apoptotic Signaling

(2010) Pankaj Chaudhary et al.   BIOCHEMISTRY

Role of Lipid Peroxidation in Cellular Responses tod,l-Sulforaphane, a Promising Cancer Chemopreventive Agent

(2010) Rajendra Sharma et al.   BIOCHEMISTRY

Pomegranate Ellagitannin-Derived Compounds Exhibit Antiproliferative and Antiaromatase Activity in Breast Cancer Cells In vitro

(2010) L. S. Adams et al.   Cancer Prevention Research

Role of 4-hydroxynonenal in epidermal growth factor receptor-mediated signaling in retinal pigment epithelial cells

(2010) Rit Vatsyayan et al.   EXPERIMENTAL EYE RESEARCH

Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression

(2010) Douglas S. Micalizzi et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Sulforaphane induces DNA single strand breaks in cultured human cells

(2010) Piero Sestili et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Inhibition of Autophagy Potentiates Sulforaphane-Induced Apoptosis in Human Colon Cancer Cells

(2009) Takeshi Nishikawa et al.   ANNALS OF SURGICAL ONCOLOGY

Activation of several concurrent proapoptic pathways by sulforaphane in human colon cancer cells SW620

(2009) E. Rudolf et al.   FOOD AND CHEMICAL TOXICOLOGY

Chemopreventive agent sulforaphane enhances radiosensitivity in human tumor cells

(2009) Dong Yu et al.   INTERNATIONAL JOURNAL OF CANCER

Creatine supplementation prevents the inhibition of myogenic differentiation in oxidatively injured C2C12 murine myoblasts

(2009) Piero Sestili et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Cellular Responses to Cancer Chemopreventive Agent D,L-Sulforaphane in Human Prostate Cancer Cells Are Initiated by Mitochondrial Reactive Oxygen Species

(2009) Dong Xiao et al.   PHARMACEUTICAL RESEARCH

4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells

(2008) Abha Sharma et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Sulforaphane induces DNA double strand breaks predominantly repaired by homologous recombination pathway in human cancer cells

(2008) Emiko Sekine-Suzuki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sulforaphane generates reactive oxygen species leading to mitochondrial perturbation for apoptosis in human leukemia U937 cells

(2008) Woo Young Choi et al.   BIOMEDICINE & PHARMACOTHERAPY

Multi-targeted prevention of cancer by sulforaphane

(2008) John D. Clarke et al.   CANCER LETTERS

Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway

(2008) Marc A. Riedl et al.   CLINICAL IMMUNOLOGY

Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death

(2008) Yogesh C. Awasthi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sulforaphane targets pancreatic tumour-initiating cells by NF- B-induced antiapoptotic signalling

(2008) G Kallifatidis et al.   GUT

Peroxynitrite damages U937 cell DNA via the intermediate formation of mitochondrial oxidants

(2008) Orazio Cantoni et al.   IUBMB LIFE

Role of Reactive Oxygen Intermediates in Cellular Responses to Dietary Cancer Chemopreventive Agents

(2008) Jedrzej Antosiewicz et al.   PLANTA MEDICA

Sulforaphane inhibition of monocyte adhesion via the suppression of ICAM-1 and NF-κB is dependent upon glutathione depletion in endothelial cells

(2008) Yen-Chin Liu et al.   VASCULAR PHARMACOLOGY

Curcumin as “Curecumin”: From kitchen to clinic

(2007) Ajay Goel et al.   BIOCHEMICAL PHARMACOLOGY

4-Hydroxynonenal Self-Limits Fas-Mediated DISC-Independent Apoptosis by Promoting Export of Daxx from the Nucleus to the Cytosol and Its Binding to Fas†

(2007) Rajendra Sharma et al.   BIOCHEMISTRY