Review
Biochemistry & Molecular Biology
Sergio Rius-Perez, Salvador Perez, Michel B. Toledano, Juan Sastre
Summary: Redox signaling through mtROS plays a crucial role in multiple mechanisms of regulated cell death and contributes decisively to the development of inflammatory disorders.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Pharmacology & Pharmacy
Yanyan Yin, Tianyao Jiang, Yutong Hao, Ji Zhang, Wen Li, Yongwei Hao, Wei He, Yu Song, Qianhua Feng, Weiwei Ma
Summary: Based on the interference of calcium and ferric ions, the CaO2/Tf/CUR nanoparticles offer a synergistic combination of ferroptosis, Ca2+ overload therapy, and chemotherapy for cancer treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Kevin Wang, Amanda Moore, Cathryn Grayson, Ryan J. Mailloux
Summary: In this study, it was found that pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (KGDH) are important sources of hydrogen peroxide (H2O2) and key sites for redox regulation. The inhibition of KGDH by S-nitroso-glutathione (GSNO) is more sensitive compared to PDH, and the deactivation of both enzymes by nitro modification is affected by sex and diet. Overall, this study demonstrates for the first time that GSNO deactivates H2O2 production by α-keto acid dehydrogenases and shows that sex and diet are determinants for the nitro-inhibition of both KGDH and PDH.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Qianqian Sun, Bin Liu, Ruoxi Zhao, Lili Feng, Zhao Wang, Shuming Dong, Yushan Dong, Shili Gai, He Ding, Piaoping Yang
Summary: Mitochondria play a crucial role in cell function by maintaining Ca2+ homeostasis and disrupting this balance can lead to tumor cell death. Calcium overload in tumor cells and tissue calcification inhibit tumor growth and can be used as contrast agents for computed tomography imaging.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Physiology
Bogdan Iaparov, Iuliia Baglaeva, Ivan Zahradnik, Alexandra Zahradnikova
Summary: Ryanodine receptor channels in calcium release sites of cardiac myocytes operate based on calcium-induced calcium release. This study investigates the competition and inhibition effects of Mg2+ on the activation of Ryanodine receptors (RyRs) in vitro and explores the impact of Mg2+ on calcium release using an in silico model. The results reveal that Mg2+ can modulate the formation and activation speed of calcium sparks, and altering Mg2+ binding parameters significantly affects calcium release events. These findings suggest that Mg2+ functions as a negative modulator of the coupling strength among RyRs, attenuating the positive feedback of the calcium-induced calcium-release mechanism.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Engineering, Environmental
Shuqi Zhang, Yan Wei, Jordin Metz, Shengbing He, Pedro J. J. Alvarez, Mingce Long
Summary: The study developed an efficient Fenton-like system using CaO2/BC composites as oxidants and tartaric acid-chelated Fe(III) as catalysts, enhancing Fe(II) regeneration and SMX degradation. The system showed higher efficiency in utilizing O-2(center dot-) for Fe(II) regeneration and enhancing SMX degradation. Positive correlation was found between SMX degradation rates and EPR signal intensities of biochar-derived persistent free radicals in CaO2/BC.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Ryan J. Mailloux
Summary: Mitochondria primarily produce superoxide and hydrogen peroxide, with the latter being considered the main ROS emitted into the cell. While H2O2 is now recognized as a central component in redox signaling, it has been suggested that superoxide may also act as a signal in mammalian cells.
Article
Biochemistry & Molecular Biology
Anita Ayer, Daniel J. Fazakerley, David E. James, Roland Stocker
Summary: This review examines the evidence linking mitochondrial reactive oxygen species with insulin resistance, highlighting their potential role in the development of this condition. However, limitations in current research methods and the lack of data connecting mitochondrial reactive oxygen species with cytosolic insulin signaling pathways present significant obstacles to proving this mechanistic link. Future studies are needed to provide stronger evidence on the relationship between mitochondrial reactive oxygen species and insulin resistance, potentially paving the way for new therapeutic strategies.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Physiology
Kay-Pong Yip, Luisa Ribeiro-Silva, Byeong Cha, Timo Rieg, James S. K. Sham
Summary: This study investigated the increase of intracellular Ca2+ induced by AVP and its relation to the protein Epac in mpkCCD cells. It found that Epac agonists can release Ca2+ from the endoplasmic reticulum into the cytoplasm and shuttle Ca2+ from the endoplasmic reticulum into mitochondria. These findings are important for understanding the regulation of mitochondrial Ca2+ and renal tubular functions.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Engy A. Abdel-Rahman, Salma Hosseiny, Abdullah Aaliya, Mohamed Adel, Basma Yasseen, Abdelrahman Al-Okda, Yasmine Radwan, Saber H. Saber, Nada Elkholy, Eslam Elhanafy, Emily E. Walker, Juan P. Zuniga-Hertz, Hemal H. Patel, Helen R. Griffiths, Sameh S. Ali
Summary: During sleep, cardiac mitochondria exhibit higher calcium retention capacity and uptake rates, along with changes in the expression of various genes and proteins. While oxygen utilization and membrane potential of cardiac mitochondria are lower during sleep, ROS production is increased, possibly due to mitochondrial calcium sequestration.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Materials Science, Biomaterials
Hong Yu, Jiale Sun, Kepeng She, Mingqi Lv, Yiqiao Zhang, Yawen Xiao, Yangkun Liu, Changhao Han, Xinyue Xu, Shuqing Yang, Guixue Wang, Guangchao Zang
Summary: The most common socioeconomic healthcare issues in clinical practice are burns, surgical incisions, and other skin injuries. This study developed a nano-spray using cross-linked amorphous calcium peroxide (CaO2) nanoparticles of polyacrylic acid (PAA) for treating skin wounds. The nano-spray showed significant advantages in promoting wound healing and inhibiting bacterial growth, with infected rats' skin defects healing in 12 days.
REGENERATIVE BIOMATERIALS
(2023)
Review
Plant Sciences
John T. Hancock
Summary: Inert gases like xenon and molecular hydrogen have significant biological effects, possibly through their interaction with protein structures. Hydrogen may also interact with redox active compounds, while the possibility of these compounds interacting with xenon pockets and cavities in proteins is being explored.
Review
Pharmacology & Pharmacy
Mohit M. Hulsurkar, Satadru K. Lahiri, Jason Karch, Meng C. Wang, Xander H. T. Wehrens
Summary: This article discusses the abnormal calcium signaling between organelles and its role in heart diseases. It examines various calcium channels and transporters involved in inter-organellar calcium signaling and highlights the dysregulation of calcium homeostasis in cardiac diseases. Furthermore, it suggests that targeting these calcium channels may represent a promising therapeutic strategy for heart diseases.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2022)
Review
Cell Biology
Liang Sun, Huafeng Wei
Summary: Progressive neuronal demise plays a crucial role in various neurodegenerative disorders, with limited and challenging therapeutic strategies available. Developing broad-spectrum drugs based on common mechanisms may offer an alternative approach for treating NDDs, while emerging research highlights the significance of dysfunctional ryanodine receptors in NDDs and proposes novel therapeutic strategies.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Review
Physiology
Satvik Mareedu, Emily D. Million, Dongsheng Duan, Gopal J. Babu
Summary: Duchenne muscular dystrophy is a muscle-wasting disease caused by the loss of dystrophin, leading to muscle degeneration, necrosis, inflammation, and eventual weakness and premature death. Abnormal elevation of intracellular calcium in the dystrophin-deficient muscle is a major contributing factor to disease progression. Targeting calcium-handling proteins and mechanisms could be a promising therapeutic strategy for DMD.
FRONTIERS IN PHYSIOLOGY
(2021)