Article
Cell Biology
Yonglun Kong, Xiaoduo Zhao, Miaojuan Qiu, Yu Lin, Pinning Feng, Suchun Li, Baien Liang, Qing Zhu, Hui Huang, Chunling Li, Weidong Wang
Summary: The Mas receptor plays a crucial role in lipid-induced kidney injury, regulating autophagy and ER stress in obesity-related kidney diseases. Activation of Mas receptor leads to mitochondrial injuries and membrane potential changes.
CELL DEATH & DISEASE
(2021)
Article
Urology & Nephrology
Chaoyi Yuan, Guannan Jin, Pengcheng Li, Wei Wang, Chang Ge, Yonglong Pan, Qiaofeng Zhang, Jie Mo, Dong Kuang, Liu Liu, Xuewu Zhang, Huifang Liang, Wanguang Zhang, Xi Tang, Zifu Li, Jihong Liu, Gang Xu, Xiaoping Chen, Ze-yang Ding, Bixiang Zhang
Summary: Tubulointerstitial fibrosis is the final path of progressive chronic kidney diseases regardless of the cause. The transcriptional intermediary factor 1y (TIF1y) has been found to be highly expressed in the kidney tubules and inhibits the progression of fibrosis. Loss of TIF1y exacerbates tubular cell polyploidy and fibrosis, while overexpression protects against kidney fibrosis. TIF1y exerts its antifibrotic role by inhibiting TGF-D and EGFR signaling pathways.
KIDNEY INTERNATIONAL
(2023)
Article
Materials Science, Multidisciplinary
Jianhua Dong, Weiwei Li, Hualin Fan
Summary: Buckling induced tubes (BITs) were designed based on modal analysis of straight-walled triangular tubes to reduce the initial peak force (IPF) and improve the crushing force efficiency (CFE) of tubular energy absorbers. The crushing mechanism of the BIT under quasi-static compression was revealed through finite element analysis (FEA) and theoretical analysis. Compared with straight tubes, high-order mode BITs have lower IPF but greater mean crushing force (MCF), CFE, and specific energy absorption (SEA).
MATERIALS & DESIGN
(2021)
Article
Cell Biology
Rui Yan, Kun Chen, Bowen Wang, Ke Xu
Summary: A highly elongated tubular ER-Golgi intermediate compartment (t-ERGIC) that selectively expedites the ER-to-Golgi transport for soluble cargoes of the receptor SURF4 has been discovered. The t-ERGIC has a distinctive elongated and thinned shape, and is marked by the small GTPases Rabl A/B instead of the canonical ERGIC marker ERGIC-53. It accelerates the trafficking of SURF4-bound cargoes with its large surface-to-volume ratio, high intracellular traveling speeds, and ER-Golgi recycling capabilities.
DEVELOPMENTAL CELL
(2022)
Article
Microbiology
Seul Kim, Eunsuk Kim, Hyunjin Yoon
Summary: Salmonella alters cellular processes to improve intracellular fitness during host infection by rewiring cellular transcriptional regulation through alternative sigma factors such as rpoS. Deprivation of outer membrane protein YcfR in Salmonella Typhimurium leads to decreased intracellular survival and downregulation of SPI-2 genes, which is abolished in the absence of rpoS. RpoS-associated stress responses in Salmonella due to impaired envelope integrity may reciprocally downregulate the expression of SPI-2 genes to reduce its virulence.
FRONTIERS IN MICROBIOLOGY
(2021)
Editorial Material
Urology & Nephrology
Raquel Esteras, Pablo Cannata-Ortiz, Marta del Palacio-Tamarit, Melania Guerrero-Hue, Cristina Garcia-Caballero, Jesus Egido, Javier Gimeno, Alberto Ortiz, Carolina Gracia-Iguacel, Juan Antonio Moreno
Summary: The AngioJet technique combines localized thrombolysis and percutaneous mechanical thrombectomy. PMT may cause acute kidney injury, with evidence of Hb-induced tubular injury and podocyte stress in renal biopsy, supporting the existence of multiple kidney cellular targets.
CLINICAL KIDNEY JOURNAL
(2021)
Review
Cell Biology
Alison Heggie, Ondrej Cerny, David W. Holden
Summary: This passage explores how Salmonella enterica manipulates the F-actin meshwork within host cells to create SCVs through invasion and replication. The study reveals that the Salmonella pathogenicity island 2 encoded effector protein, SteC, plays a crucial role in this process.
CELLULAR MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Christopher T. S. Lim, M. Norhafizah, D. Sani, S. N. Tan, C. W. Lim, Brian P. Kirby, A. Ideris, J. Stanslas
Summary: AKI, a preventable and treatable disease, lacks effective medication. Edible bird nests containing sialic acids and epidermal growth factor have shown potential reno-protective properties in studies.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Hak Joo Lee, Meenalakshmi M. Mariappan, Luke Norton, Terry Bakewell, Denis Feliers, Sae Byeol Oh, Andrew Donati, Cherubina S. Rubannelsonkumar, Manjeri A. Venkatachalam, Stephen E. Harris, Isabelle Rubera, Michel Tauc, Goutam Ghosh Choudhury, C. Ronald Kahn, Kumar Sharma, Ralph A. DeFronzo, Balakuntalam S. Kasinath
Summary: The role of insulin receptor in obesity-induced kidney injury was studied in mice, with results showing that renal proximal tubule IR activation is necessary for HFD-induced kidney injury in male mice, while female mice are resistant to it.
Article
Engineering, Biomedical
Yu Yuan, Ying Liu, Yang He, Bingkun Zhang, Liang Zhao, Simin Tian, Qimeng Wang, Shanan Chen, Zekun Li, Shuang Liang, Guohua Hou, Bin Liu, Yuan Li
Summary: In this study, a novel intestinal responsively nanotubes-in-microgel composite carrier was developed for the targeted and oral delivery of capsaicin (Cap) to effectively alleviate Salmonella-induced enteritis and maintain gut microbiota homeostasis.
Article
Biotechnology & Applied Microbiology
Feng Lu, Siyu Ruan, Yunliang Li, Yining Wang, Pengfei Xie, Xiaoxue Zhao, Jiapin Chao, Haile Ma
Summary: Helium-neon (He-Ne) laser mutagenesis was utilized to assess DNA mutagenicity in Salmonella typhimurium TA97a, TA98, TA100, and TA102. Optimal laser treatment was found to be 6 hours during the mid-logarithmic growth stage. Low-power laser inhibited cell growth, while continued treatment stimulated metabolism. The findings provide a theoretical basis for further exploration of laser-induced mutagenesis breeding.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Coral Garcia-Pastor, Selma Benito-Martinez, Ricardo J. Bosch, Ana B. Fernandez-Martinez, Francisco J. Lucio-Cazana
Summary: Proximal tubular cells (PTC) are vulnerable to hypoxia-induced apoptosis, which may be a crucial factor in kidney diseases. Research has shown that apoptosis under hypoxia is mediated by COX-2-dependent production of PGE(2), suggesting potential new therapeutic targets for preventing hypoxia-dependent lesions in renal diseases.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Wenshu Zou, Jingyan Zhang, Kai Zhang, Zhiping Peng, Ruihua Xin, Lei Wang, Jianxi Li
Summary: This study found that Asiatic acid (AA) can attenuate microglial inflammation induced by Salmonella typhimurium (S.T). AA upregulated the expression of lncRNA TVX1, leading to the suppression of pro-inflammatory factors and inhibition of the NF-κB pathway and NLRP3 inflammasome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Theodoros Eleftheriadis, Georgios Pissas, Georgios Filippidis, Maria Efthymiadi, Vassilios Liakopoulos, Ioannis Stefanidis
Summary: Gliflozins, such as dapagliflozin, can inhibit cell senescence pathways and prevent renal tubular epithelial cell (RPTEC) senescence. High glucose induces oxidative stress and leads to a senescence-associated secretory phenotype. Dapagliflozin reduces glucose consumption and inhibits related pathways, effectively preventing cell senescence. Investigating the effects of gliflozins on cell senescence has potential significance for the treatment of diabetic nephropathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Integrative & Complementary Medicine
Huiling Liu, Zhou Huang, Hong Jiang, Ke Su, Zilin Si, Wenhui Wu, Hanyu Wang, Dongxue Li, Ninghua Tan, Zhihao Zhang
Summary: This study found that dihydroartemisinin can improve renal aging and injury by activating autophagy. It suggests that activation of autophagy and elimination of senescent cells may be an effective strategy for preventing kidney damage and fibrosis.
CHINESE JOURNAL OF NATURAL MEDICINES
(2023)
Article
Multidisciplinary Sciences
Sara V. Pais, Charlotte E. Key, Vitor Borges, Ines S. Pereira, Joao Paulo Gomes, Derek J. Fisher, Luis Jaime Mota
SCIENTIFIC REPORTS
(2019)
Article
Immunology
Matthieu Million, Maxime Gaudin, Clea Melenotte, Lionel Chasson, Sophie Edouard, Constance Verdonk, Elsa Prudent, Bernard Amphoux, Stephane Meresse, Richard Dorent, Hubert Lepidi, Bernard La Scola, Jean-Pierre Gorvel, Christelle Desnues, Didier Raoult
CLINICAL INFECTIOUS DISEASES
(2020)
Article
Cell Biology
Clara Degos, Lisiena Hysenaj, Gabriela Gonzalez-Espinoza, Vilma Arce-Gorvel, Aurelie Gagnaire, Alexia Papadopoulos, Karina Alejandra Pasquevich, Stephane Meresse, Juliana Cassataro, Sylvie Memet, Jean-Pierre Gorvel
CELLULAR MICROBIOLOGY
(2020)
Article
Cell Biology
Lucrecia Alberdi, Alexandra Vergnes, Jean-Baptiste Manneville, Dumizulu L. Tembo, Ziyan Fang, Yaya Zhao, Nina Schroeder, Audrey Dumont, Margaux Lagier, Patricia Bassereau, Lorena Redondo-Morata, Jean-Pierre Gorvel, Stephane Meresse
JOURNAL OF CELL SCIENCE
(2020)
Article
Microbiology
Fernando Chimal-Cazares, Gabriela Hernandez-Martinez, Sabino Pacheco, Miguel A. Ares, Jorge Soria-Bustos, Manuel Sanchez-Gutierrez, Jeannett A. Izquierdo-Vega, Jose Antonio Ibarra, Jorge A. Gonzalez-Y-Merchand, Jean-Pierre Gorvel, Stephane Meresse, Miguel A. De la Cruz
FRONTIERS IN MICROBIOLOGY
(2020)
Review
Cell Biology
Jona Karam, Stephane Meresse, Laurent Kremer, Wassim Daher
CELLULAR MICROBIOLOGY
(2020)
Article
Multidisciplinary Sciences
Thanida Laopanupong, Pinidphon Prombutara, Phongthon Kanjanasirirat, Salisa Benjaskulluecha, Atsadang Boonmee, Tanapat Palaga, Stephane Meresse, Jiraporn Paha, Tegar Adriansyah Putra Siregar, Tanawadee Khumpanied, Suparerk Borwornpinyo, Angkana Chaiprasert, Pongsak Utaisincharoen, Marisa Ponpuak
Summary: This study showed that specific genes such as Kxd1 and Plekhm2 are upregulated in macrophages infected with autophagy-resistant Beijing strain of Mycobacterium tuberculosis, compared to those infected with the reference strain H37Rv, leading to suppression of lysosome positioning and delivery during starvation-induced autophagy. These genes play a crucial role in allowing the BJN strain to evade autophagic restriction and survive within host cells.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Ziyan Fang, Mathieu Fallet, Thomas Moest, Jean-Pierre Gorvel, Stephane Meresse
Summary: In this study, it was found that the microtubule molecular motor KIF1B beta plays a key role in the establishment of the Salmonella replication niche, and its absence affects the stability of bacterial vacuoles and the formation of associated tubules. Kinesin-3 interacts with the Salmonella effector SifA and the host protein complex SKIP. The presence of SifA establishes a recruitment pathway for kinesin-1 and kinesin-3 in infected cells.
JOURNAL OF CELL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Joana N. Bugalhao, Maria P. Luis, Ines S. Pereira, Maria da Cunha, Sara Pais, Luis Jaime Mota
Summary: CT006 is a novel protein in C. trachomatis that can associate with lipid droplets (LDs) and may participate in the interaction between LDs and C. trachomatis inclusions.
Article
Multidisciplinary Sciences
S. Holbert, E. Barilleau, S. M. Roche, J. Trotereau, S. Georgeault, J. Burlaud-Gaillard, A. Wiedemann, S. Meresse, I Virlogeux-Payant, P. Velge
Summary: Numerous studies have shown that the Salmonella Pathogenicity Island 1-encoded type III secretion system (T3SS1) apparatus and its associated effectors play a key role in the invasion and intracellular fate of Salmonella in host cells. Some cell lines have been identified where Salmonella Typhimurium can enter without using its three known invasion factors. In the murine AML12 hepatocyte cell line, the T3SS1 mutant induced an intracellular fate similar to the wild-type strain, indicating that invasion and survival of Salmonella Typhimurium can be independent of T3SS1.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Ines P. Monteiro, Sofia Sousa, Vitor Borges, Paulo Goncalves, Joao Paulo Gomes, Luis Jaime Mota, Irina S. Franco
Summary: Two novel effectors, VFX05045 and VFX10045, of Legionella pneumophila were identified and their subcellular localizations were determined. Furthermore, the essential residues for nuclear targeting of VFX10045 were identified.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Ines Serrano Pereira, Sara Vilela Pais, Vitor Borges, Maria Jose Borrego, Joao Paulo Gomes, Luis Jaime Mota
Summary: A study revealed that the CteG effector protein of Chlamydia trachomatis is involved in the lytic exit of host cells. Cells infected with wild-type C. trachomatis released more infectious chlamydiae in the culture supernatant compared to cells infected with a CteG-deficient strain. CteG also played a role in host cell cytotoxicity. Furthermore, CteG and Pgp4 were found to participate in a cascade of events leading to host cell lysis and release of infectious chlamydiae.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Editorial Material
Immunology
Isaura Simoes, Daniel E. Voth, Luis Jaime Mota
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Maria Pequito Luis, Ines Serrano Pereira, Joana N. Bugalhao, CatarinaN Simoes, Cristiano Mota, Maria Joao Romao, Luis Jaime Mota
Summary: Chlamydia trachomatis is a bacterial pathogen that infects the eyes and genitourinary system in humans. Its ability to grow inside host cells in a membrane-bound compartment called an inclusion relies on effector proteins that are transported by a type III secretion system. One of these effector proteins, IncM, was found to play a role in inhibiting host cell cytokinesis and inducing multinucleation in infected cells.
INFECTION AND IMMUNITY
(2023)
Review
Cell Biology
Joana N. Bugalhao, Luis Jaime Mota