Engineering RNA-binding proteins with diverse activities

Analysis of RNA decay factor mediated RNA stability contributions on RNA abundance

(2015) Sho Maekawa et al.   BMC GENOMICS

KH–RNA interactions: back in the groove

(2015) Giuseppe Nicastro et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Specific RNA Recognition by Designer Pentatricopeptide Repeat Protein

(2015) Cuicui Shen et al.   Molecular Plant

The solution structure of the pentatricopeptide repeat protein PPR10 upon binding atpH RNA

(2015) Benjamin S. Gully et al.   NUCLEIC ACIDS RESEARCH

Spontaneous Dominant Mutations in Chlamydomonas Highlight Ongoing Evolution by Gene Diversification

(2015) Alix Boulouis et al.   PLANT CELL

TwoChlamydomonasOPR proteins stabilize chloroplast mRNAs encoding small subunits of photosystem II and cytochromeb6f

(2015) Fei Wang et al.   PLANT JOURNAL

AEF1/MPR25 is implicated in RNA editing of plastidatpFand mitochondrialnad5, and also promotesatpFsplicing in Arabidopsis and rice

(2015) Aaron Yap et al.   PLANT JOURNAL

The design and structural characterization of a synthetic pentatricopeptide repeat protein

(2015) Benjamin S. Gully et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Bidirectional Regulation of mRNA Translation in Mammalian Cells by Using PUF Domains

(2014) Jicong Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genome Engineering with Targetable Nucleases

(2014) Dana Carroll   Annual Review of Biochemistry

Pentatricopeptide Repeat Proteins in Plants

(2014) Alice Barkan et al.   Annual Review of Plant Biology

The Splicing Factor RBM4 Controls Apoptosis, Proliferation, and Migration to Suppress Tumor Progression

(2014) Yang Wang et al.   CANCER CELL

Expanding the genetic editing tool kit: ZFNs, TALENs, and CRISPR-Cas9

(2014) Rajat M. Gupta et al.   JOURNAL OF CLINICAL INVESTIGATION

A protein-RNA specificity code enables targeted activation of an endogenous human transcript

(2014) Zachary T Campbell et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An mTERF domain protein functions in group II intron splicing in maize chloroplasts

(2014) Kamel Hammani et al.   NUCLEIC ACIDS RESEARCH

RAP, the Sole Octotricopeptide Repeat Protein in Arabidopsis, Is Required for Chloroplast 16S rRNA Maturation

(2014) L. Kleinknecht et al.   PLANT CELL

Arabidopsis mTERF15 Is Required for Mitochondrial nad2 Intron 3 Splicing and Functional Complex I Activity

(2014) Ya-Wen Hsu et al.   PLoS One

Prevalent RNA recognition motif duplication in the human genome

(2014) Y. S. Tsai et al.   RNA

The splicing activator DAZAP1 integrates splicing control into MEK/Erk-regulated cell proliferation and migration

(2014) Rajarshi Choudhury et al.   Nature Communications

An artificial PPR scaffold for programmable RNA recognition

(2014) Sandrine Coquille et al.   Nature Communications

NSUN4 Is a Dual Function Mitochondrial Protein Required for Both Methylation of 12S rRNA and Coordination of Mitoribosomal Assembly

(2014) Metodi Dimitrov Metodiev et al.   PLoS Genetics

Modular assembly of designer PUF proteins for specific post-transcriptional regulation of endogenous RNA

(2014) Zhanar Abil et al.   Journal of Biological Engineering

Tetramolecular Fluorescence Complementation for Detection of Specific RNAs in Vitro

(2013) Stefanie Julia Kellermann et al.   CHEMBIOCHEM

Engineering RNA-binding proteins for biology

(2013) Yu Chen et al.   FEBS Journal

Engineered proteins with Pumilio/fem-3mRNA binding factor scaffold to manipulate RNA metabolism

(2013) Yang Wang et al.   FEBS Journal

Treatment of Type 1 Myotonic Dystrophy by Engineering Site-specific RNA Endonucleases that Target (CUG) n Repeats

(2013) Wenjing Zhang et al.   MOLECULAR THERAPY

Structural basis for the modular recognition of single-stranded RNA by PPR proteins

(2013) Ping Yin et al.   NATURE

Structural basis for RNA recognition by a dimeric PPR-protein complex

(2013) Jiyuan Ke et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The potential for manipulating RNA with pentatricopeptide repeat proteins

(2013) Yusuke Yagi et al.   PLANT JOURNAL

Elucidation of the RNA Recognition Code for Pentatricopeptide Repeat Proteins Involved in Organelle RNA Editing in Plants

(2013) Yusuke Yagi et al.   PLoS One

Improved Computational Target Site Prediction for Pentatricopeptide Repeat RNA Editing Factors

(2013) Mizuki Takenaka et al.   PLoS One

Correction of mutations within the cystic fibrosis transmembrane conductance regulator by site-directed RNA editing

(2013) M. F. Montiel-Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mRNA fate

(2013) Michela A. Denti et al.   RNA Biology

Fluorescent Probes for Imaging Endogenous β-Actin mRNA in Living Cells Using Fluorescent Protein-Tagged Pumilio

(2012) Hideaki Yoshimura et al.   ACS Chemical Biology

Gene transfer to skeletal muscle by site-specific delivery of electroporation and ultrasound

(2012) Yuanli Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Alternative Cleavage and Polyadenylation during Colorectal Cancer Development

(2012) A. R. Morris et al.   CLINICAL CANCER RESEARCH

Human Pumilio Proteins Recruit Multiple Deadenylases to Efficiently Repress Messenger RNAs

(2012) Jamie Van Etten et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Understanding the role of domain–domain linkers in the spatial orientation of domains in multi-domain proteins

(2012) Ramachandra M. Bhaskara et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Protein-based nanocarriers as promising drug and gene delivery systems

(2012) Ahmed O. Elzoghby et al.   JOURNAL OF CONTROLLED RELEASE

A Eukaryotic Translation Initiation Factor 4E-Binding Protein Promotes mRNA Decapping and Is Required for PUF Repression

(2012) N. H. Blewett et al.   MOLECULAR AND CELLULAR BIOLOGY

Modular recognition of nucleic acids by PUF, TALE and PPR proteins

(2012) Aleksandra Filipovska et al.   Molecular BioSystems

Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

(2012) Karen Adelman et al.   NATURE REVIEWS GENETICS

A complex network of factors with overlapping affinities represses splicing through intronic elements

(2012) Yang Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Intronic splicing enhancers, cognate splicing factors and context-dependent regulation rules

(2012) Yang Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II

(2012) Stéphane Larochelle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cell-penetrating peptides: breaking through to the other side

(2012) Erez Koren et al.   TRENDS IN MOLECULAR MEDICINE

Pre-mRNA splicing in disease and therapeutics

(2012) Ravi K. Singh et al.   TRENDS IN MOLECULAR MEDICINE

Engineering RNA endonucleases with customized sequence specificities

(2012) Rajarshi Choudhury et al.   Nature Communications

A Combinatorial Amino Acid Code for RNA Recognition by Pentatricopeptide Repeat Proteins

(2012) Alice Barkan et al.   PLoS Genetics

Apolipoprotein B mRNA-editing, catalytic polypeptide cytidine deaminases and retroviral restriction

(2012) Atsushi Koito et al.   Wiley Interdisciplinary Reviews-RNA

E2F mediates enhanced alternative polyadenylation in proliferation

(2012) Ran Elkon et al.   GENOME BIOLOGY

Visualization of Nonengineered Single mRNAs in Living Cells Using Genetically Encoded Fluorescent Probes

(2011) Toshimichi Yamada et al.   ANALYTICAL CHEMISTRY

Specific and Modular Binding Code for Cytosine Recognition in Pumilio/FBF (PUF) RNA-binding Domains

(2011) Shuyun Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drosophila Pumilio Protein Contains Multiple Autonomous Repression Domains That Regulate mRNAs Independently of Nanos and Brain Tumor

(2011) C. A. Weidmann et al.   MOLECULAR AND CELLULAR BIOLOGY

A universal code for RNA recognition by PUF proteins

(2011) Aleksandra Filipovska et al.   Nature Chemical Biology

The prospects for designer single-stranded RNA-binding proteins

(2011) Joel P Mackay et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The evolution of RNA editing and pentatricopeptide repeat genes

(2011) Sota Fujii et al.   NEW PHYTOLOGIST

Targeted translational regulation using the PUF protein family scaffold

(2011) A. Cooke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Designer RNA-binding proteins: New tools for manipulating the transcriptome

(2011) Aleksandra Filipovska et al.   RNA Biology

Targeted Genome Editing Across Species Using ZFNs and TALENs

(2011) Andrew J. Wood et al.   SCIENCE

Alternate Modes of Cognate RNA Recognition by Human PUMILIO Proteins

(2011) Gang Lu et al.   STRUCTURE

The Discovery of Zinc Fingers and Their Applications in Gene Regulation and Genome Manipulation

(2010) Aaron Klug   Annual Review of Biochemistry

Functions and Regulation of RNA Editing by ADAR Deaminases

(2010) Kazuko Nishikura   Annual Review of Biochemistry

Helix Unwinding and Base Flipping Enable Human MTERF1 to Terminate Mitochondrial Transcription

(2010) Elena Yakubovskaya et al.   CELL

Toward a General Approach for RNA-Templated Hierarchical Assembly of Split-Proteins

(2010) Jennifer L. Furman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Pumilio-induced RNA structure switch in p27-3′ UTR controls miR-221 and miR-222 accessibility

(2010) Martijn Kedde et al.   NATURE CELL BIOLOGY

A single Arabidopsis organellar protein has RNase P activity

(2010) Anthony Gobert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Global Changes in Processing of mRNA 3' Untranslated Regions Characterize Clinically Distinct Cancer Subtypes

(2009) P. Singh et al.   CANCER RESEARCH

Engineering splicing factors with designed specificities

(2009) Yang Wang et al.   NATURE METHODS

Rational Design, Selection and Specificity of Artificial Transcription Factors (ATFs): The Influence of Chromatin in Target Gene Regulation

(2008) Pilar Blancafort et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

RNA-binding proteins and post-transcriptional gene regulation

(2008) Tina Glisovic et al.   FEBS LETTERS

Live-cell imaging of viral RNA genomes using a Pumilio-based reporter

(2008) Jens Tilsner et al.   PLANT JOURNAL

Splicing regulation: From a parts list of regulatory elements to an integrated splicing code

(2008) Z. Wang et al.   RNA

Diverse RNA-Binding Proteins Interact with Functionally Related Sets of RNAs, Suggesting an Extensive Regulatory System

(2008) Daniel J Hogan et al.   PLOS BIOLOGY