Dose-Response Modeling of Etoposide-Induced DNA Damage Response

Can case study approaches speed implementation of the NRC report: “Toxicity Testing in the 21st Century: A Vision and a Strategy?”

(2014) Melvin Andersen   ALTEX-Alternatives to Animal Experimentation

Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise

(2012) Marc R Birtwistle et al.   BMC Systems Biology

Topoisomerase IIβ associates with Ku70 and PARP-1 during double strand break repair of DNA in neurons

(2011) Rajakumar Mandraju et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Transcriptional modulation induced by ionizing radiation: p53 remains a central player

(2011) Sharon Rashi-Elkeles et al.   Molecular Oncology

Replication Stress Induces Micronuclei Comprising of Aggregated DNA Double-Strand Breaks

(2011) Bing Xu et al.   PLoS One

Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide

(2011) C.-C. Wu et al.   SCIENCE

Bistability versus Bimodal Distributions in Gene Regulatory Processes from Population Balance

(2011) Che-Chi Shu et al.   PLoS Computational Biology

Stochastic Modeling of B Lymphocyte Terminal Differentiation and Its Suppression by Dioxin

(2010) Qiang Zhang et al.   BMC Systems Biology

Basal Dynamics of p53 Reveal Transcriptionally Attenuated Pulses in Cycling Cells

(2010) Alexander Loewer et al.   CELL

Computational Systems Biology and Dose-Response Modeling in Relation to New Directions in Toxicity Testing

(2010) Qiang Zhang et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Wip1 phosphatase is associated with chromatin and dephosphorylates γH2AX to promote checkpoint inhibition

(2010) L Macůrek et al.   ONCOGENE

Noise Can Induce Bimodality in Positive Transcriptional Feedback Loops Without Bistability

(2010) T.-L. To et al.   SCIENCE

Defining Network Topologies that Can Achieve Biochemical Adaptation

(2009) Wenzhe Ma et al.   CELL

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

Stochastic Modeling and Simulation of the p53-MDM2/MDMX Loop

(2009) Xiaodong Cai et al.   JOURNAL OF COMPUTATIONAL BIOLOGY

Etoposide pathway

(2009) Jun Yang et al.   Pharmacogenetics and Genomics

Numerical Analysis of Etoposide Induced DNA Breaks

(2009) Aida Muslimović et al.   PLoS One

Cell fate decision mediated by p53 pulses

(2009) X.-P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription-coupled DNA Double-Strand Breaks Are Mediated via the Nucleotide Excision Repair and the Mre11-Rad50-Nbs1 Complex

(2008) Josée Guirouilh-Barbat et al.   MOLECULAR BIOLOGY OF THE CELL

Recurrent Initiation: A Mechanism for Triggering p53 Pulses in Response to DNA Damage

(2008) Eric Batchelor et al.   MOLECULAR CELL

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

(2008) J. E. Deweese et al.   NUCLEIC ACIDS RESEARCH