Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise

Biology using engineering tools

(2011) Marc R. Birtwistle et al.   CELL CYCLE

Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells

(2011) Edita Aksamitiene et al.   CELLULAR SIGNALLING

Ligand-Specific c-Fos Expression Emerges from the Spatiotemporal Control of ErbB Network Dynamics

(2010) Takashi Nakakuki et al.   CELL

Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells

(2010) Y. Taniguchi et al.   SCIENCE

The Mammalian MAPK/ERK Pathway Exhibits Properties of a Negative Feedback Amplifier

(2010) O. E. Sturm et al.   Science Signaling

Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells

(2009) Jayajit Das et al.   CELL

Dynamics and Variability of ERK2 Response to EGF in Individual Living Cells

(2009) Cellina Cohen-Saidon et al.   MOLECULAR CELL

The Incoherent Feedforward Loop Can Provide Fold-Change Detection in Gene Regulation

(2009) Lea Goentoro et al.   MOLECULAR CELL

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

(2009) Sabrina L. Spencer et al.   NATURE

Stochastic modelling for quantitative description of heterogeneous biological systems

(2009) Darren J. Wilkinson   NATURE REVIEWS GENETICS

Protein Dynamics in Individual Human Cells: Experiment and Theory

(2009) Ariel Aharon Cohen et al.   PLoS One

Differential Effects of EGFR Ligands on Endocytic Sorting of the Receptor

(2009) Kirstine Roepstorff et al.   TRAFFIC

Four-dimensional dynamics of MAPK information-processing systems

(2009) Boris N. Kholodenko et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Activation of the MAPK Module from Different Spatial Locations Generates Distinct System Outputs

(2008) Kerry Inder et al.   MOLECULAR BIOLOGY OF THE CELL

Transcriptome-wide noise controls lineage choice in mammalian progenitor cells

(2008) Hannah H. Chang et al.   NATURE

Origin of the sharp boundary that discriminates positive and negative selection of thymocytes

(2008) A. Prasad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analytical distributions for stochastic gene expression

(2008) V. Shahrezaei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Molecular Memory and Bursting on Fluctuations in Gene Expression

(2008) J. M. Pedraza et al.   SCIENCE