Visualizing and Manipulating Focal Adhesion Kinase Regulation in Live Cells

FERM control of FAK function: Implications for cancer therapy

(2014) Ssang-Taek Lim et al.   CELL CYCLE

A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl) -3, 5, 7-triaza-1-azoniatricyclo [3.3.1.13,7]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo

(2012) V. M. Golubovskaya et al.   CARCINOGENESIS

FAK or talin: who goes first?

(2012) Kim Baumann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

How focal adhesion kinase achieves regulation by linking ligand binding, localization and action

(2011) Stefan T Arold   CURRENT OPINION IN STRUCTURAL BIOLOGY

Lysophosphatidic acid induces a migratory phenotype through a crosstalk between RhoA–Rock and Src–FAK signalling in colon cancer cells

(2011) Fernanda Leve et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

An Ion-insensitive cAMP Biosensor for Long Term Quantitative Ratiometric Fluorescence Resonance Energy Transfer (FRET) Measurements under Variable Physiological Conditions

(2011) Petrus S. Salonikidis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Focal adhesion kinase inhibitors are potent anti-angiogenic agents

(2011) Miguel A. Cabrita et al.   Molecular Oncology

Systematic control of protein interaction using a modular ER/K  -helix linker

(2011) S. Sivaramakrishnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

The FERM domain: organizing the structure and function of FAK

(2010) Margaret C. Frame et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Expression of focal adhesion kinase and phosphorylated focal adhesion kinase in human gliomas is associated with unfavorable overall survival

(2010) Lianshu Ding et al.   Translational Research

Signal transduction by focal adhesion kinase in cancer

(2009) Jihe Zhao et al.   CANCER AND METASTASIS REVIEWS

Tyrosine Phosphorylation of Growth Factor Receptor-bound Protein-7 by Focal Adhesion Kinase in the Regulation of Cell Migration, Proliferation, and Tumorigenesis

(2009) Pei-Yu Chu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

B Cell Receptor-induced Phosphorylation of Pyk2 and Focal Adhesion Kinase Involves Integrins and the Rap GTPases and Is Required for B Cell Spreading

(2009) Kathy W. K. Tse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic conformational changes in the FERM domain of FAK are involved in focal-adhesion behavior during cell spreading and motility

(2009) E. Papusheva et al.   JOURNAL OF CELL SCIENCE

Enhanced interaction between focal adhesion and adherens junction proteins: Involvement in sphingosine 1-phosphate-induced endothelial barrier enhancement

(2009) Xiaoguang Sun et al.   MICROVASCULAR RESEARCH

Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK

(2008) Sara M. Weis et al.   JOURNAL OF CELL BIOLOGY

Structural Basis of Protein Kinase C Isoform Function

(2008) Susan F. Steinberg   PHYSIOLOGICAL REVIEWS

Dynamic charge interactions create surprising rigidity in the ER/K  -helical protein motif

(2008) S. Sivaramakrishnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA