Review
Biochemistry & Molecular Biology
Dusan Pastorek, Martina Culenova, Maria Csobonyeiova, Veronika Skuciova, Lubos Danisovic, Stanislav Ziaran
Summary: Tissue engineering is a promising and effective approach, but there are still many challenges to address in the field of urethral repair. Better trial design, improved cooperation among research groups, and centralization could lead to the commercialization and routine use of TE products for urethral reconstruction.
Review
Biochemistry & Molecular Biology
Martina Casarin, Alessandro Morlacco, Fabrizio Dal Moro
Summary: This review summarizes the strategies and biomaterials used in pediatric urological reconstruction, with a focus on tissue regeneration and the role of seeded cells and growth factors. It highlights the importance of these techniques in pediatric applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Saeed Farzamfar, Megan Richer, Mahya Rahmani, Mohammad Naji, Mehdi Aleahmad, Stephane Chabaud, Stephane Bolduc
Summary: Urethral reconstruction strategies are limited due to lack of suitable tissues that can withstand urine exposure. However, tissue engineering using biological macromolecule-based scaffolds offers potential solutions to prevent urine leakage. This review discusses recent advances, applications, and challenges in urethral reconstruction using biological macromolecule-based scaffolds.
Review
Pharmacology & Pharmacy
Ravi Kumar Bandaru, Smruti Rekha Rout, Gowtham Kenguva, Bapi Gorain, Nabil A. Alhakamy, Prashant Kesharwani, Rambabu Dandela
Summary: The pharmacokinetics of active pharmaceutical ingredients in solid dosage forms rely heavily on their solid-state characteristics, which can be altered through strategies such as cocrystallization. This method allows for tuning the properties of APIs without compromising therapeutic efficacy, and has been highlighted as an important tool in pharmaceutical development. Regulatory guidelines and challenges associated with cocrystal-based products in the pharmaceutical industry have also been discussed in the review.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hong Y. Choi, Senna Choi, Iulia Iatan, Isabelle Ruel, Jacques Genest
Summary: ATP-binding cassette transporter A1 (ABCA1) is a molecular defect in Tangier disease, characterized by the absence of high-density lipoprotein cholesterol (HDL-C) in the circulation and the accumulation of cholesterol in lymphoid tissues. Atherosclerosis is caused by the accumulation of cholesterol in arteries, while HDL-C levels are inversely associated with the presence of atherosclerotic cardiovascular disease (ASCVD). Strategies to increase ABCA1 expression and activity have been studied to reduce ASCVD, but no successful clinical trials have been conducted yet. This review discusses the current understanding, challenges, and future directions in ABCA1 research for developing therapies for ASCVD.
Review
Biochemistry & Molecular Biology
Bogdan Obrisca, Bogdan Sorohan, Liliana Tuta, Gener Ismail
Summary: SLE is an autoimmune disorder caused by a loss of tolerance to endogenous nuclear antigens, triggering an aberrant autoimmune response. LN, a major cause of morbidity and mortality in SLE patients, has seen recent advancements in understanding its genetic and molecular basis, leading to the development of newer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Swati Sharma, Bikramjit Basu
Summary: This review provides an update on the different biomaterial-based strategies for restoring the dynamic function of dysfunctional bladder tissue. The perspectives of bladder tissue engineering and total bladder replacement are discussed, with a focus on scaffold-mediated regenerative medicine and the development of a biostable bladder prosthesis, respectively. The challenges and advancements in the field are highlighted, including the need for vascularization, innervation, 3D prototype fabrication, and prevention of urinary encrustation. The potential of bioelectronic medicine in urology is also explored.
Article
Materials Science, Multidisciplinary
Asim Mushtaq, Ruibo Zhao, Dandan Luo, Eithne Dempsey, Xiumei Wang, M. Zubair Iqbal, Xiangdong Kong
Summary: Nanoscale magnetic hydroxyapatite nanoparticles have shown great potential in various biomedical applications, especially in cancer theranostics, due to their good stability and biocompatibility. Current research is focused on the controlled fabrication and structure-property relationships, while further exploration and development are needed in areas such as cancer treatment, tissue engineering, antimicrobial activity, etc. The multifunctional capabilities of MHAp nanoparticles and their potential in hybrid nanocarriers for biomedical applications are still being actively studied and improved.
MATERIALS & DESIGN
(2021)
Review
Engineering, Biomedical
Wenying Wei, Honglian Dai
Summary: Osteochondral defect regeneration remains a challenging issue in the musculoskeletal system, with traditional clinical treatments showing limited efficacy. However, the development of tissue engineering has provided more promising results in regenerating damaged osteochondral tissues.
BIOACTIVE MATERIALS
(2021)
Article
Biophysics
Neha Bhattacharyya, Dipanjan Mukherjee, Soumendra Singh, Ria Ghosh, Saurav Karmakar, Ankita Mallick, Arpita Chattopadhyay, Pulak Mondal, Tapan Mondal, Debasis Bhattacharyya, Asim Kumar Mallick, Ghulam Nabi, Samir Kumar Pal
Summary: This study aims to develop an efficient and cost-effective diagnostic device for urinary bladder cancer. By using specific fluorescent dyes, the device can detect the presence of volatile organic compounds in urine, distinguishing UBC samples from healthy controls. Clinical trials have demonstrated the device's high sensitivity and accuracy, and it can also reveal the grade and prognosis of UBC based on sample processing mechanism.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Materials Science, Biomaterials
Kankan Qin, Cleo Parisi, Francisco M. Fernandes
Summary: Ice templating, originally used for shaping colloidal suspensions into lightweight ceramics, has evolved to fabricate materials mimicking biological tissues and now used for creating biomaterials containing living cells. This technique has progressed to cope with labile biological matter and may shape the future of 3D cell culture, tissue engineering, and cryobiology.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Review
Biochemistry & Molecular Biology
Saeed Farzamfar, Elissa Elia, Stephane Chabaud, Mohammad Naji, Stephane Bolduc
Summary: Electrospun scaffolds show great potential in urethral defect repair by mimicking native cells' niches and delivering drugs and cells, but there are still challenges and issues to be addressed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Surgery
Xingdou Mu, Juliang Zhang, Yue Jiang
Summary: Surgical management of breast cancer often results in breast loss, and current breast reconstruction methods may not be sufficient for tissue replacement needs. Tissue engineering using emerging materials shows promise in generating suitable replacements. Three-dimensional printing technology has gained significant interest and application in the medical field, particularly in complex medical situations requiring anatomical surgical considerations and precise reconstructive procedures.
FRONTIERS IN SURGERY
(2021)
Review
Engineering, Biomedical
Yi Cui, Weiyuan Liu, Shuaijing Zhao, Yannan Zhao, Jianwu Dai
Summary: Tissue engineering aims to generate functional biological substitutes to repair, sustain, improve, or replace tissue function affected by disease. The application of simulated microgravity has become an active topic in the field of tissue engineering due to its advantages in modulating cellular morphology, metabolism, secretion, proliferation, and stem cell differentiation. There have been many achievements in constructing bioartificial spheroids, organoids, or tissue analogs under simulated microgravity conditions, and the current status, recent advances, challenges, and prospects of microgravity related to tissue engineering are reviewed.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Polymer Science
Jian Yang, Haojie Yu, Li Wang, Jian Liu, Xiaowei Liu, Yichuan Hong, Yudi Huang, Shuning Ren
Summary: Adhesive hydrogels as emerging biomedical materials have attracted much attention for their potential applications in tissue engineering. They possess excellent adhesion, biocompatibility, degradability, and antibacterial properties, making them suitable for hemostatic agents, sealants, and other applications.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Cell & Tissue Engineering
Ingrid Saba, Corinne Barat, Stephane Chabaud, Nolan Reyjon, Maude Leclerc, Weronika Jakubowska, Hazem Orabi, Asmaa Lachhab, Martin Pelletier, Michel J. Tremblay, Stephane Bolduc
Summary: This study presents an innovative immunocompetent three-dimensional human organ-specific vaginal mucosa model, free of exogenous material, for in vitro modeling of human immunodeficiency virus type-1 (HIV-1) infection. The model closely resembles native tissue histologically, particularly by showing glycogen accumulation in the superficial cells of the epithelium, responsive to estrogen, and capable of maintaining a population of monocyte-derived macrophages infected or not by HIV-1 for approximately two months.
TISSUE ENGINEERING PART C-METHODS
(2021)
Review
Environmental Sciences
Eve Pellerin, Christophe Caneparo, Stephane Chabaud, Stephane Bolduc, Martin Pelletier
Summary: Bisphenols are endocrine-disrupting chemicals that have been linked to cancer progression, particularly prostate cancer. They are found in the urine of the vast majority of the population and could potentially impact the normal physiology and cancer development of the bladder.
ENVIRONMENTAL RESEARCH
(2021)
Article
Urology & Nephrology
Elisabeth Lapointe, Narcisse Singbo, Elizabeth Naud, Stephane Bolduc
Summary: Propiverine has shown to be an efficient and safe option for treating OAB in children, with an increase in bladder capacity and expected bladder capacity observed in patients on the medication. The drug offered comparable efficacy and tolerability when compared to other molecules used in historical cohorts.
CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL
(2022)
Article
Urology & Nephrology
Bruno Turcotte, Lynda Belanger, Anne-Sophie Blais, Annie-Claude Blouin, Stephane Bolduc, Amelie Bolduc-Mokhtar, Michel Bureau, Yves Caumartin, Jonathan Cloutier, Marie-Pier Deschenes-Rompre, Thierry Dujardin, Yves Fradet, Noemie Gaudreau, Louis Lacombe, Katherine Moore, Fannie Morin, Genevieve Nadeau, Sophie Paquet, Francis Simard, David Simonyan, Frederic Soucy, Rabi Tiguert, Paul Toren, Michele Lodde, Frederic Pouliot
Summary: This study aimed to assess patients' experience and satisfaction with telemedicine in urology and compare them with urologists' perceptions. The results showed that despite high patient satisfaction rates, almost half of the patients would have preferred in-person visits.
CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Sophie Ramsay, Elisabeth Lapointe, Stephane Bolduc
Summary: Overactive bladder (OAB) is a chronic condition highly prevalent in children, and conservative measures should be the first line of treatment. When conservative management fails, pharmacological options are considered, although only two agents are currently approved for pediatric use. Treatment for OAB in children requires a structured, stepwise approach, active involvement of children and their families, and close monitoring of side effects and medication adherence.
EXPERT OPINION ON PHARMACOTHERAPY
(2022)
Article
Oncology
Stephane Chabaud, Eve Pellerin, Christophe Caneparo, Cassandra Ringuette-Goulet, Frederic Pouliot, Stephane Bolduc
Summary: The hypoxic condition during tumor growth has a significant impact on the survival and migration properties of bladder cancer cells. Low-grade bladder cancer cells tend to become more aggressive under hypoxic culture conditions, while high-grade cells tend to exhibit less aggressive characteristics. Hypoxia greatly alters the properties of bladder cancer cells, including matrix metalloproteinases expression and metabolic changes. Studying bladder cancer cells in hypoxic environments is vital for translating in vitro findings to an in vivo context.
Article
Oncology
Martial Millet, Enola Bollmann, Cassandra Ringuette Goulet, Genevieve Bernard, Stephane Chabaud, Marc-Etienne Huot, Frederic Pouliot, Stephane Bolduc, Francois Bordeleau
Summary: A study on the physical properties of tumors demonstrates that a 3D self-assembly bladder model constructed with cancer-associated fibroblasts can effectively recapitulate the biological and mechanical features of tumors. The model exhibited increased extracellular matrix content, remodeling, and stiffness in the stroma assembled by cancer-associated fibroblasts. Additionally, normal urothelial cells seeded on the tumor model displayed tumor-like responses, including increased cell proliferation, cell infiltration, and features of epithelial-to-mesenchymal transition.
Article
Microbiology
Charlene Roussel, Stephane Chabaud, Jacob Lessard-Lord, Valentina Cattero, Felix-Antoine Pellerin, Perrine Feutry, Valerie Bochard, Stephane Bolduc, Yves Desjardins
Summary: Uropathogenic Escherichia coli (UPEC) are the primary cause of recurrent urinary tract infections. The poor understanding of UPEC ecology-pathophysiology from its reservoir-the gut, to its infection site-the urothelium, partly explains the inadequate and abusive use of antibiotics to treat UTI, which leads to a dramatic upsurge in antibiotic-resistance cases. In this study, the effects of cranberry proanthocyanidins (PAC)-rich extract microbial metabolites on UPEC virulence and fitness were evaluated. The results demonstrated that PAC-rich cranberry extract microbial metabolites significantly reduce the activation of UPEC virulence genes in the gut reservoir, suggesting their potential in preventing UTI.
MICROBIOLOGY SPECTRUM
(2022)
Review
Biochemistry & Molecular Biology
David Brownell, Stephane Chabaud, Stephane Bolduc
Summary: Female gynecological organ dysfunction has a negative impact on the quality of life for women, and current treatment options are inadequate. Tissue engineering provides a potential alternative for repairing or replacing dysfunctional gynecological organs, with the aim of restoring female fertility and sexual wellbeing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Eve Pellerin, Felix-Antoine Pellerin, Stephane Chabaud, Frederic Pouliot, Martin Pelletier, Stephane Bolduc
Summary: The study reveals that glucuronidated BPs have different effects on normal urothelial cells and bladder cancer cells. They decrease the activity of normal cells but increase the bioenergetics and activity of cancer cells. This suggests that the ubiquitous presence of BP metabolites in urine could promote the progression of bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Saeed Farzamfar, Elissa Elia, Stephane Chabaud, Mohammad Naji, Stephane Bolduc
Summary: Electrospun scaffolds show great potential in urethral defect repair by mimicking native cells' niches and delivering drugs and cells, but there are still challenges and issues to be addressed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Christophe Caneparo, Stephane Chabaud, Julie Fradette, Stephane Bolduc
Summary: Growing demand in various industries has led to an increase in in vitro cell cultures. However, the use of fetal bovine serum comes with challenges such as unknown constitution, potential contamination, and limited production. A Serum-Free Medium (SFM) has been developed to address these issues. The study showed that SFM enables cell proliferation and is more suitable for epithelial cells compared to the traditional medium. However, further optimization is needed for fibroblast proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Eve Pellerin, Felix-Antoine Pellerin, Stephane Chabaud, Frederic Pouliot, Stephane Bolduc, Martin Pelletier
Summary: This study evaluated the effects of BPA and BPS on the bioenergetics, proliferation, and migration of bladder urothelial cells and bladder cancer cells. The results showed that chronic exposure to BPA and BPS decreased energy metabolism in urothelial cells while increasing it in bladder cancer cells. This suggests that BPA and BPS exposure could promote bladder cancer development.
Review
Biochemistry & Molecular Biology
Elissa Elia, David Brownell, Stephane Chabaud, Stephane Bolduc
Summary: This passage discusses the similarities between the gastrointestinal and genitourinary tracts, which both consist of hollow structures that rely on muscle contractions to facilitate the flow of materials. It describes the anatomy, pathologies, and treatments of these organs, with a particular emphasis on tissue engineering strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biotechnology & Applied Microbiology
Christophe Caneparo, David Brownell, Stephane Chabaud, Stephane Bolduc
Summary: Tissue engineering aims to produce 3D tissues by creating scaffolds and seeding cells to mimic interactions between tissues and cells. Urology and gynaecology fields face challenges of insufficient treatment options, requiring more representative research models based on human anatomy.
BIOENGINEERING-BASEL
(2021)