Synthesis of Pyrazole Derivatives Possessing Anticancer Activity: Current Status

Global estimates of cancer prevalence for 27 sites in the adult population in 2008

(2012) Freddie Bray et al.   INTERNATIONAL JOURNAL OF CANCER

Discovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (c-MET) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the Treatment of Cancer

(2012) J. Jean Cui et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of 3-(1H-indol-3-yl)pyrazole-5-carboxylic acid derivatives

(2011) Datong Zhang et al.   ARCHIVES OF PHARMACAL RESEARCH

Synthesis of novel pyrazolo[1,5- a ]pyrazin-4(5 H )-one derivatives and their inhibition against growth of A549 and H322 lung cancer cells

(2011) Liang-Wen Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates and evaluation of their Src kinase inhibitory and anticancer activities

(2011) Anil Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of 5-benzyl-2-phenylpyrazolo[1,5-a]pyrazin-4,6(5H,7H)-dione derivatives and discovery of an apoptosis inducer for H322 lung cancer cells

(2011) Hong-Shui Lv et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Use of a total traffic count metric to investigate the impact of roadways on asthma severity: a case-control study

(2011) Angus G Cook et al.   Environmental Health

Efficient microwave-assisted synthesis and antitumor activity of novel 4,4′-methylenebis[2-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)phenols]

(2011) Braulio Insuasty et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Branched-chain C-cyano pyranonucleosides: Synthesis of 3′-C-cyano & 3′-C-cyano-3′-deoxy pyrimidine pyranonucleosides as novel cytotoxic agents

(2011) Christos Kiritsis et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New diarylureas and diarylamides containing 1,3,4-triarylpyrazole scaffold: Synthesis, antiproliferative evaluation against melanoma cell lines, ERK kinase inhibition, and molecular docking studies

(2011) Won-Kyoung Choi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and anticancer activities of some novel 2-(benzo[d]thiazol-2-yl)-8-substituted-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones

(2011) Raísa da R. Reis et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of pyrazolo[3,4-b]pyridines under microwave irradiation in multi-component reactions and their antitumor and antimicrobial activities – Part 1

(2011) M.A. El-borai et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tri- and Tetrasubstituted Pyrazole Derivates: Regioisomerism Switches Activity from p38MAP Kinase to Important Cancer Kinases

(2011) Bassam Abu Thaher et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and anticancer effects of pongamol derivatives on mitogen signaling and cell cycle kinases

(2011) R. Ranga Rao et al.   MEDICINAL CHEMISTRY RESEARCH

Novel pyrrolidinone and pyrazolo[1,5-a][1,3,5]triazine derivatives bearing a biologically active sulfamoyl moiety as a new class of antitumor agents

(2011) Hala M. Aly   MONATSHEFTE FUR CHEMIE

N-aryl pyrazoles: DFT calculations of CH acidity and deprotonative metallation using a combination of lithium and zinc amides

(2011) Floris Chevallier et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Pyrazolone-fused combretastatins and their precursors: synthesis, cytotoxicity, antitubulin activity and molecular modeling studies

(2010) Bojan Burja et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of novel 3,5-diaryl pyrazole derivatives using combinatorial chemistry as inhibitors of tyrosinase as well as potent anticancer, anti-inflammatory agents

(2010) Babasaheb P. Bandgar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel pyrazole derivatives: Synthesis and evaluation of anti-angiogenic activity

(2010) Michael S. Christodoulou et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Polysubstituted pyrazoles, part 6. Synthesis of some 1-(4-chlorophenyl)-4-hydroxy-1H-pyrazol-3-carbonyl derivatives linked to nitrogenous heterocyclic ring systems as potential antitumor agents

(2010) Sherif A.F. Rostom   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents

(2010) Peng-Cheng Lv et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of novel pyrazolic analogues of chalcones and their 3-aryl-4-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)-1-phenyl-1H-pyrazole derivatives as potential antitumor agents

(2010) Braulio Insuasty et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of 1-benzyl-3-(5-hydroxymethyl-2-furyl)selenolo[3,2-c]pyrazole derivatives as new anticancer agents

(2010) Li-Chen Chou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of Potent Pyrazolo[4,3-h]quinazoline-3-carboxamides as Multi-Cyclin-Dependent Kinase Inhibitors†

(2010) Gabriella Traquandi et al.   JOURNAL OF MEDICINAL CHEMISTRY

4-(Pyrazol-4-yl)-pyrimidines as Selective Inhibitors of Cyclin-Dependent Kinase 4/6

(2010) Young Shin Cho et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phthalazinone Pyrazoles as Potent, Selective, and Orally Bioavailable Inhibitors of Aurora-A Kinase

(2010) Michael E. Prime et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, characterization, antioxidant, and anticancer studies of 6-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]-3-[(2-naphthyloxy)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole in HepG2 cell lines

(2010) Dhanya Sunil et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis, characterization and in vitro cytotoxic properties of some new Schiff and Mannich bases in Hep G2 cells

(2010) Dhanya Sunil et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis of new series of pyrazolo[4,3-d]pyrimidin-7-ones and pyrido[2,3-d]pyrimidin-4-ones for their bacterial and cyclin-dependent kinases (CDKs) inhibitory activities

(2010) Detlef Geffken et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis, single-crystal characterization and preliminary biological evaluation of novel ferrocenyl pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives

(2009) Yong-Sheng Xie et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification ofN,1,4,4-Tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a Potent, Orally Available Cyclin Dependent Kinase Inhibitor

(2009) Maria Gabriella Brasca et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent Advances in the Synthesis of Pyrazoles. A Review

(2009) Santos Fustero et al.   ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL

Structure-Based Optimization of Pyrazolo[3,4-d]pyrimidines as Abl Inhibitors and Antiproliferative Agents toward Human Leukemia Cell Lines

(2008) Fabrizio Manetti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification ofN-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design†

(2008) Paul G. Wyatt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity†

(2008) Steven Howard et al.   JOURNAL OF MEDICINAL CHEMISTRY

Base-Mediated Reaction of Hydrazones and Nitroolefins with a Reversed Regioselectivity:  A Novel Synthesis of 1,3,4-Trisubstituted Pyrazoles

(2008) Xiaohu Deng et al.   ORGANIC LETTERS

4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer

(2007) Paul A. Brough et al.   JOURNAL OF MEDICINAL CHEMISTRY