期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 45, 期 4, 页码 1395-1402出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2009.12.039
关键词
Selenolopyrazole; Thienopyrazole; Furopyrazole; YC-1 analogs; Structure-activity relationships (SAR); Cytotoxicity
资金
- National Science Council of the Republic of China [NSC 96-2628-B039-001, NSC 97-2320-B-039-003-MY3]
As part of our continuing search for potential anticancer drug candidates among YC-1 analogs, 1,3-disubstituted selenolo[3,2-c]pyrazole derivatives were synthesized and evaluated for their cytotoxicity against NCI-H226 non-small cell lung cancer and A-498 renal cancer cell lines. Significant cytotoxicity was observed in 3-(5-hydroxymethy1-2-furyl) derivatives (2, 33, 36 and 37). Among them, compound 2 was found to have the most potent activity. The mode of action of compound 2 seems to differ from those of the 175 anticancer agents listed in NCI's standard database and resembles that of YC-1. Thus, we recommend that compound 2 should be developed further as new drug candidate for treatment of non-small cell lung cancer and renal cancer. (C) 2009 Elsevier Masson SAS. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据