Alzheimer's disease: β-amyloid plaque formation in human brain

Chronic treatment with a novel γ-secretase modulator, JNJ-40418677, inhibits amyloid plaque formation in a mouse model of Alzheimer's disease

(2011) B Van Broeck et al.   BRITISH JOURNAL OF PHARMACOLOGY

Alzheimer Disease: Advances in Pathogenesis, Diagnosis, and Therapy

(2011) M. D. Pasic et al.   CLINICAL CHEMISTRY

Amyloid β (Aβ) and phospho-tau (p-tau) as diagnostic biomarkers in Alzheimer's disease

(2011) David Prvulovic et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Transgenic Mice as a Model of Pre-Clinical Alzheimers Disease

(2011) M. T. Ferretti et al.   Current Alzheimer Research

Monoclonal antibodies against β-amyloid (Aβ) for the treatment of Alzheimer's disease: the Aβ target at a crossroads

(2011) Francesco Panza et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Large Quantities of Aβ Peptide Are Constitutively Released during Amyloid Precursor Protein Metabolismin Vivoandin Vitro

(2011) Abhay Moghekar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nature of the Amyloid-β Monomer and the Monomer-Oligomer Equilibrium

(2011) Suman Nag et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low-n oligomers as therapeutic targets of Alzheimer’s disease

(2011) Kenjiro Ono et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid-beta oligomers increase the localization of prion protein at the cell surface

(2011) Fabiana A. Caetano et al.   JOURNAL OF NEUROCHEMISTRY

Brain Oligomeric β-Amyloid but Not Total Amyloid Plaque Burden Correlates With Neuronal Loss and Astrocyte Inflammatory Response in Amyloid Precursor Protein/Tau Transgenic Mice

(2011) Bibiana DaRocha-Souto et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

CD45 Deficiency Drives Amyloid-  Peptide Oligomers and Neuronal Loss in Alzheimer's Disease Mice

(2011) Y. Zhu et al.   JOURNAL OF NEUROSCIENCE

Amyloid  -Induced Death in Neurons Involves Glial and Neuronal Hemichannels

(2011) J. A. Orellana et al.   JOURNAL OF NEUROSCIENCE

Extracellular and intraneuronal HMW-AbetaOs represent a molecular basis of memory loss in Alzheimer's disease model mouse

(2011) Ayumi Takamura et al.   Molecular Neurodegeneration

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Orally Administrated Cinnamon Extract Reduces β-Amyloid Oligomerization and Corrects Cognitive Impairment in Alzheimer's Disease Animal Models

(2011) Anat Frydman-Marom et al.   PLoS One

C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-  (A ) and acts in concert with A  to elicit neuronal and behavioral deficits in mice

(2011) N. Bien-Ly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease

(2011) Guriqbal S Basi et al.   Alzheimers Research & Therapy

IP/MS analysis of human CSF Aβ following a single dose of the C-terminal anti-Aβ antibody ponezumab (PF-04360365) to Alzheimer patients

(2010) Kathleen M. Wood et al.   Alzheimers & Dementia

Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions

(2010) David W. Klaver et al.   BIOLOGICAL CHEMISTRY

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

(2010) Dun-Sheng Yang et al.   BRAIN

The Development of New Therapeutics for Alzheimer's Disease

(2010) M D Carter et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

All Roads to Schizophrenia Lead to Dopamine Supersensitivity and Elevated Dopamine D2High Receptors

(2010) Philip Seeman   CNS Neuroscience & Therapeutics

Amyloid-β Protein Oligomer at Low Nanomolar Concentrations Activates Microglia and Induces Microglial Neurotoxicity

(2010) Izumi Maezawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-Methyl-d-aspartate receptors are required for synaptic targeting of Alzheimer’s toxic amyloid-β peptide oligomers

(2010) Helena Decker et al.   JOURNAL OF NEUROCHEMISTRY

Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β-peptide elimination from the brain

(2010) Berislav V. Zlokovic et al.   JOURNAL OF NEUROCHEMISTRY

The Acyl-Coenzyme A: Cholesterol Acyltransferase Inhibitor CI-1011 Reverses Diffuse Brain Amyloid Pathology in Aged Amyloid Precursor Protein Transgenic Mice

(2010) Henri J. Huttunen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Liver X Receptor Agonist Treatment Ameliorates Amyloid Pathology and Memory Deficits Caused by High-Fat Diet in APP23 Mice

(2010) N. F. Fitz et al.   JOURNAL OF NEUROSCIENCE

Modulation of ABCA1 by an LXR Agonist Reduces Beta-Amyloid Levels and Improves Outcome after Traumatic Brain Injury

(2010) David J. Loane et al.   JOURNAL OF NEUROTRAUMA

11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study

(2010) Juha O Rinne et al.   LANCET NEUROLOGY

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

Systemic treatment with liver X receptor agonists raises apolipoprotein E, cholesterol, and amyloid-β peptides in the cerebral spinal fluid of rats

(2010) Sokreine Suon et al.   Molecular Neurodegeneration

Genome-wide association studies: the key to unlocking neurodegeneration?

(2010) Sonia Gandhi et al.   NATURE NEUROSCIENCE

Stabilization of neurotoxic Alzheimer amyloid-  oligomers by protein engineering

(2010) A. Sandberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits

(2010) R. Tamayev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary zinc supplementation of 3xTg-AD mice increases BDNF levels and prevents cognitive deficits as well as mitochondrial dysfunction

(2010) C Corona et al.   Cell Death & Disease

Amyloid-β fibrillogenesis: Structural insight and therapeutic intervention

(2009) Kevin A. DaSilva et al.   EXPERIMENTAL NEUROLOGY

β-amyloid oligomers and cellular prion protein in Alzheimer’s disease

(2009) Erik C. Gunther et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Begacestat (GSI-953): A Novel, Selective Thiophene Sulfonamide Inhibitor of Amyloid Precursor Protein  -Secretase for the Treatment of Alzheimer's Disease

(2009) R. L. Martone et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

(2009) Fernanda G. De Felice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A worldwide multicentre comparison of assays for cerebrospinal fluid biomarkers in Alzheimer's disease

(2009) N A Verwey et al.   ANNALS OF CLINICAL BIOCHEMISTRY

P4-351: Effects of uninterrrupted intravenous immunoglobulin treatment of Alzheimer's disease for nine months

(2008) Diamanto Tsakanikas et al.   Alzheimers & Dementia

Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease

(2008) Alex E. Roher et al.   Alzheimers & Dementia

Synthesis of scyllo-inositol derivatives and their effects on amyloid beta peptide aggregation

(2008) Yedi Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY

[3H]BMS-599240 — A novel tritiated ligand for the characterization of BACE1 inhibitors

(2008) Lawrence G. Iben et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Modulation of amyloid-β aggregation and toxicity by inosose stereoisomers

(2008) Mark Nitz et al.   FEBS Journal

The Ratio of Monomeric to Aggregated Forms of Aβ40 and Aβ42 Is an Important Determinant of Amyloid-β Aggregation, Fibrillogenesis, and Toxicity

(2008) Asad Jan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY