Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases

Neuroprotective Effects of the Cellular Prion Protein in Autoimmune Optic Neuritis

(2011) Sarah K. Williams et al.   AMERICAN JOURNAL OF PATHOLOGY

Coordination Features and Affinity of the Cu2+Site in the α-Synuclein Protein of Parkinson’s Disease

(2011) Christopher G. Dudzik et al.   BIOCHEMISTRY

Affinity of Cu+for the Copper-Binding Domain of the Amyloid-β Peptide of Alzheimer’s Disease

(2011) Heather A. Feaga et al.   INORGANIC CHEMISTRY

Aluminum, copper, iron and zinc differentially alter amyloid-Aβ1–42 aggregation and toxicity

(2011) Silvia Bolognin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Brief update on different roles of tau in neurodegeneration

(2011) Arne Ittner et al.   IUBMB LIFE

Distinct Effects of Zn2+, Cu2+, Fe3+, and Al3+on Amyloid-β Stability, Oligomerization, and Aggregation

(2011) Wei-Ting Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper(II)-Induced Secondary Structure Changes and Reduced Folding Stability of the Prion Protein

(2011) Nadine D. Younan et al.   JOURNAL OF MOLECULAR BIOLOGY

Copper Redox Cycling in the Prion Protein Depends Critically on Binding Mode

(2011) Lin Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular-Level Examination of Cu2+Binding Structure for Amyloid Fibrils of 40-Residue Alzheimer’s β by Solid-State NMR Spectroscopy

(2011) Sudhakar Parthasarathy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dietary intake of metals and risk of Parkinson's disease: A case-control study in Japan

(2011) Yoshihiro Miyake et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Toward a Mechanism of Prion Misfolding and Structural Models of PrPSc: Current Knowledge and Future Directions

(2011) Will C. Guest et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Interactions of Zn(ii) and Cu(ii) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity

(2011) Vello Tõugu et al.   Metallomics

Role of metal dyshomeostasis in Alzheimer's disease

(2011) David J. Bonda et al.   Metallomics

Dietary intake and olfactory function in patients with newly diagnosed Parkinson's disease: a case-control study

(2011) Emma Ådén et al.   NUTRITIONAL NEUROSCIENCE

Alpha-Synuclein Is a Cellular Ferrireductase

(2011) Paul Davies et al.   PLoS One

Preparation and Characterization of Neurotoxic Tau Oligomers

(2010) Cristian A. Lasagna-Reeves et al.   BIOCHEMISTRY

The Synucleins Are a Family of Redox-Active Copper Binding Proteins

(2010) Paul Davies et al.   BIOCHEMISTRY

PONDR-FIT: A meta-predictor of intrinsically disordered amino acids

(2010) Bin Xue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Mercury(II) promotes the in vitro aggregation of tau fragment corresponding to the second repeat of microtubule-binding domain: Coordination and conformational transition

(2010) Dan-Jing Yang et al.   BIOPOLYMERS

Flexible Nets of Malleable Guardians: Intrinsically Disordered Chaperones in Neurodegenerative Diseases

(2010) Vladimir N. Uversky   CHEMICAL REVIEWS

Multitude of binding modes attainable by intrinsically disordered proteins: a portrait gallery of disorder-based complexes

(2010) Vladimir N. Uversky   CHEMICAL SOCIETY REVIEWS

The transition metals copper and iron in neurodegenerative diseases

(2010) Susana Rivera-Mancía et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D2concept

(2010) Vladimir N Uversky   Expert Review of Proteomics

Mysterious oligomerization of the amyloidogenic proteins

(2010) Vladimir N. Uversky   FEBS Journal

Intrinsic disorder in proteins associated with neurodegenerative diseases

(2010) Vladimir et al.   Frontiers in Bioscience-Landmark

Iron Promotes the Toxicity of Amyloid β Peptide by Impeding Its Ordered Aggregation

(2010) Beinan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substoichiometric Levels of Cu2+Ions Accelerate the Kinetics of Fiber Formation and Promote Cell Toxicity of Amyloid-β from Alzheimer Disease

(2010) Claire J. Sarell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Manganese chelation therapy extends survival in a mouse model of M1000 prion disease

(2010) Marcus W. Brazier et al.   JOURNAL OF NEUROCHEMISTRY

Structural Characterization of a High Affinity Mononuclear Site in the Copper(II)-α-Synuclein Complex

(2010) Marco Bortolus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Automatic Assignment of the Intrinsically Disordered Protein Tau with 441-Residues

(2010) Rhagavendran L. Narayanan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exploring the Structural Details of Cu(I) Binding to α-Synuclein by NMR Spectroscopy

(2010) Andres Binolfi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metalloproteomics and metal toxicology of α-synuclein

(2010) Aaron Santner et al.   Metallomics

Raised calcium promotes α-synuclein aggregate formation

(2010) S. Nath et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Lead exposure increases levels of β-amyloid in the brain and CSF and inhibits LRP1 expression in APP transgenic mice

(2010) Huiying Gu et al.   NEUROSCIENCE LETTERS

APLP1, Alzheimer's-like pathology and neurodegeneration in the frontal cortex of manganese-exposed non-human primates

(2010) Tomás R. Guilarte   NEUROTOXICOLOGY

Biological metals and Alzheimer's disease: Implications for therapeutics and diagnostics

(2010) James A. Duce et al.   PROGRESS IN NEUROBIOLOGY

Compact conformations of α-synuclein induced by alcohols and copper

(2010) Antonino Natalello et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Manganese Upregulates Cellular Prion Protein and Contributes to Altered Stabilization and Proteolysis: Relevance to Role of Metals in Pathogenesis of Prion Disease

(2010) Christopher J. Choi et al.   TOXICOLOGICAL SCIENCES

SKN-1/Nrf2 Inhibits Dopamine Neuron Degeneration in a Caenorhabditis elegans Model of Methylmercury Toxicity

(2010) Natalia VanDuyn et al.   TOXICOLOGICAL SCIENCES

Prion hypothesis: the end of the controversy?

(2010) Claudio Soto   TRENDS IN BIOCHEMICAL SCIENCES

Deprotonation of the Asp1Ala2 Peptide Bond Induces Modification of the Dynamic Copper(II) Environment in the Amyloid-β Peptide near Physiological pH

(2009) Christelle Hureau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pulse EPR Spectroscopy Reveals the Coordination Sphere of Copper(II) Ions in the 1–16 Amyloid-β Peptide: A Key Role of the First Two N-Terminus Residues

(2009) Pierre Dorlet et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metal binding to alpha-synuclein peptides and its contribution to toxicity

(2009) David R. Brown   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Converse modulation of toxic α-synuclein oligomers in living cells by N′-benzylidene-benzohydrazide derivates and ferric iron

(2009) Andreas S. Hillmer et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Thermodynamic and Voltammetric Characterization of the Metal Binding to the Prion Protein: Insights into pH Dependence and Redox Chemistry

(2009) Paul Davies et al.   BIOCHEMISTRY

Evaluation of Copper2+Affinities for the Prion Protein

(2009) Rebecca C. Nadal et al.   BIOCHEMISTRY

Copper(II) Binding to Amyloid-β Fibrils of Alzheimer’s Disease Reveals a Picomolar Affinity: Stoichiometry and Coordination Geometry Are Independent of Aβ Oligomeric Form

(2009) Claire J. Sarell et al.   BIOCHEMISTRY

Role of copper and manganese in prion disease progression

(2009) Gerda Mitteregger et al.   BRAIN RESEARCH

Predicting intrinsic disorder in proteins: an overview

(2009) Bo He et al.   CELL RESEARCH

Copper Binding Extrinsic to the Octarepeat Region in the Prion Protein

(2009) Eric Walter et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Biophysics of Parkinsons Disease: Structure and Aggregation of α- Synuclein

(2009) Vladimir Uversky et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Unique copper-induced oligomers mediate alpha-synuclein toxicity

(2009) Josephine A. Wright et al.   FASEB JOURNAL

Identification of the Minimal Copper(II)-Binding α-Synuclein Sequence

(2009) Mark S. Jackson et al.   INORGANIC CHEMISTRY

Low Micromolar Zinc Accelerates the Fibrillization of Human Tau via Bridging of Cys-291 and Cys-322

(2009) Zhong-Ying Mo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Importance of dynamical processes in the coordination chemistry and redox conversion of copper amyloid-β complexes

(2009) Christelle Hureau et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Interaction of selected divalent metal ions with human ataxin-3 Q36

(2009) Iwona Stawoska et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Copper in the brain and Alzheimer’s disease

(2009) Ya Hui Hung et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

The Mysterious Unfoldome: Structureless, Underappreciated, Yet Vital Part of Any Given Proteome

(2009) Vladimir N. Uversky   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration

(2009) Christopher A. Shaw et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Generation of soluble oligomeric β-amyloid species via copper catalyzed oxidation with implications for Alzheimer’s disease: A DFT study

(2009) Fredrik Haeffner et al.   JOURNAL OF MOLECULAR MODELING

Zinc in the physiology and pathology of the CNS

(2009) Stefano L. Sensi et al.   NATURE REVIEWS NEUROSCIENCE

Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons

(2009) Eugene V. Mosharov et al.   NEURON

Manganese Enhances Prion Protein Survival in Model Soils and Increases Prion Infectivity to Cells

(2009) Paul Davies et al.   PLoS One

Potential Role of α-Synuclein and Metallothionein in Lead-Induced Inclusion Body Formation

(2009) Peijun Zuo et al.   TOXICOLOGICAL SCIENCES

Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept

(2008) Vladimir N. Uversky et al.   Annual Review of Biophysics

Amyloid β−Cu2+Complexes in both Monomeric and Fibrillar Forms Do Not Generate H2O2Catalytically but Quench Hydroxyl Radicals†

(2008) Rebecca C. Nadal et al.   BIOCHEMISTRY

Structural Characterization of Binding of Cu(II) to Tau Protein†

(2008) Alice Soragni et al.   BIOCHEMISTRY

Magnesium exerts both preventive and ameliorating effects in an in vitro rat Parkinson disease model involving 1-methyl-4-phenylpyridinium (MPP+) toxicity in dopaminergic neurons

(2008) Tomoyo Hashimoto et al.   BRAIN RESEARCH

Effects of chronic manganese exposure on working memory in non-human primates

(2008) J.S. Schneider et al.   BRAIN RESEARCH

Amyloidogenesis of Natively Unfolded Proteins

(2008) Vladimir Uversky   Current Alzheimer Research

α-Synuclein Misfolding and Neurodegenerative Diseases

(2008) Vladimir Uversky   CURRENT PROTEIN & PEPTIDE SCIENCE

Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-β peptide

(2008) Peter Faller et al.   DALTON TRANSACTIONS

Manganese Neurotoxicity: Lessons Learned from Longitudinal Studies in Nonhuman Primates

(2008) Neal C. Burton et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Single Particle Characterization of Iron-induced Pore-forming α-Synuclein Oligomers

(2008) Marcus Kostka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

Manganese Binding to the Prion Protein

(2008) Marcus W. Brazier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Polybasic N-Terminal Region of the Prion Protein Controls the Physical Properties of Both the Cellular and Fibrillar Forms of PrP

(2008) Valeriy G. Ostapchenko et al.   JOURNAL OF MOLECULAR BIOLOGY

Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primates

(2008) Tomás R. Guilarte et al.   JOURNAL OF NEUROCHEMISTRY

The Potential for -Structure in the Repeat Domain of Tau Protein Determines Aggregation, Synaptic Decay, Neuronal Loss, and Coassembly with Endogenous Tau in Inducible Mouse Models of Tauopathy

(2008) M.-M. Mocanu et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD

(2008) J. Wu et al.   JOURNAL OF NEUROSCIENCE

Cu2+Binding Modes of Recombinant α-Synuclein − Insights from EPR Spectroscopy

(2008) Simon C. Drew et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-Specific Interactions of Cu(II) with α and β-Synuclein: Bridging the Molecular Gap between Metal Binding and Aggregation

(2008) Andrés Binolfi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Amyloid-β Peptide of Alzheimer’s Disease Binds CuIin a Linear Bis-His Coordination Environment: Insight into a Possible Neuroprotective Mechanism for the Amyloid-β Peptide

(2008) Jason Shearer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Zinc-Amyloid β Interactions on a Millisecond Time-Scale Stabilize Non-fibrillar Alzheimer-Related Species

(2008) Dror Noy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper(II) Binding to α-Synuclein, the Parkinson’s Protein

(2008) Jennifer C. Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Elevated manganese levels in blood and CNS in human prion disease

(2008) Shirley Hesketh et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Impact of dietary exposure to food contaminants on the risk of Parkinson's disease

(2008) Maria Skaalum Petersen et al.   NEUROTOXICOLOGY

Conformational Equilibria in Monomeric α-Synuclein at the Single-Molecule Level

(2008) Massimo Sandal et al.   PLOS BIOLOGY

Potential pathogenic role of β-amyloid1–42–aluminum complex in Alzheimer's disease

(2007) Denise Drago et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Binding of zinc(II) and copper(II) to the full-length Alzheimer’s amyloid-β peptide

(2007) Vello Tõugu et al.   JOURNAL OF NEUROCHEMISTRY

NMR Studies of the Zn2+Interactions with Rat and Human β-Amyloid (1−28) Peptides in Water-Micelle Environment

(2007) Elena Gaggelli et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Calcium(II) selectively induces α-synuclein annular oligomers via interaction with the C-terminal domain

(2004) Rachel Lowe et al.   PROTEIN SCIENCE

Exacerbation of Copper Toxicity in Primary Neuronal Cultures Depleted of Cellular Glutathione

(2003) Anthony R. White et al.   JOURNAL OF NEUROCHEMISTRY