Sorafenib attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis via HIF‐1α/SLC7A11 pathway

Identification the ferroptosis-related gene signature in patients with esophageal adenocarcinoma

(2021) Lei Zhu et al.   Cancer Cell International

Carvacrol alleviates liver fibrosis by inhibiting TRPM7 and modulating the MAPK signaling pathway

(2021) Shiyi Cai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibiting xCT/SLC7A11 induces ferroptosis of myofibroblastic hepatic stellate cells but exacerbates chronic liver injury

(2021) Kuo Du et al.   LIVER INTERNATIONAL

Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells

(2020) Ariunaa Sampilvanjil et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure

(2020) Naoya Yamada et al.   Cell Death & Disease

Dose-dependent regulation of mitochondrial function and cell death pathway by sorafenib in liver cancer cells

(2020) María A. Rodríguez-Hernández et al.   BIOCHEMICAL PHARMACOLOGY

COX-2 in liver fibrosis

(2020) Hu Yang et al.   CLINICA CHIMICA ACTA

LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-β1/Smad3 pathway

(2020) Ya-ru Yang et al.   MOLECULAR IMMUNOLOGY

The BRD7-P53-SLC25A28 axis regulates ferroptosis in hepatic stellate cells

(2020) Zili Zhang et al.   Redox Biology

TRPM7 modulates macrophage polarization by STAT1/STAT6 pathways in RAW264.7 cells

(2020) Lingling Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis

(2019) Ping Wang et al.   Nature Communications

Hypoxia inducible factor‐1 promotes liver fibrosis in nonalcoholic fatty liver disease by activating PTEN/p65 signaling pathway

(2019) Jie Han et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Clockophagy is a novel selective autophagy process favoring ferroptosis

(2019) Minghua Yang et al.   Science Advances

RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells

(2019) Zili Zhang et al.   Autophagy

TRAP-seq identifies cystine/glutamate antiporter as a driver of recovery from liver injury

(2018) Amber W. Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells

(2018) Zili Zhang et al.   Autophagy

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

(2018) Xinxin Song et al.   CURRENT BIOLOGY

Burden of Liver Diseases in the World

(2018) Sumeet K. Asrani et al.   JOURNAL OF HEPATOLOGY

Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway

(2018) Zhaoyan Kong et al.   BIOMEDICINE & PHARMACOTHERAPY

P53-dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation

(2018) Ling Wang et al.   IUBMB LIFE

Mitochondrial control of apoptosis through modulation of cardiolipin oxidation in hepatocellular carcinoma: A novel link between oxidative stress and cancer

(2017) Huiqin Zhong et al.   FREE RADICAL BIOLOGY AND MEDICINE

xCT deficiency aggravates acetaminophen-induced hepatotoxicity under inhibition of the transsulfuration pathway

(2017) Eun Sil Kang et al.   FREE RADICAL RESEARCH

Characterization of ferroptosis in murine models of hemochromatosis

(2017) Hao Wang et al.   HEPATOLOGY

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Regression of Liver Fibrosis

(2017) John Iredale et al.   SEMINARS IN LIVER DISEASE

Deferoxamine ameliorates hepatosteatosis via several mechanisms inob/obmice

(2016) Han Xue et al.   Annals of the New York Academy of Sciences

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

HIF-1α triggers long-lasting glutamate excitotoxicity via system xc − in cerebral ischaemia-reperfusion

(2016) Chia-Hung Hsieh et al.   JOURNAL OF PATHOLOGY

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

(2016) Bradley A. Carlson et al.   Redox Biology

Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition

(2015) Tung-Hung Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sorafenib Blocks the HIF-1α/VEGFA Pathway, Inhibits Tumor Invasion, and Induces Apoptosis in Hepatoma Cells

(2014) Ming Xu et al.   DNA AND CELL BIOLOGY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib

(2013) Yan-Ru Deng et al.   JOURNAL OF AUTOIMMUNITY

TRPM7 channel regulates PDGF-BB-induced proliferation of hepatic stellate cells via PI3K and ERK pathways

(2013) Ling Fang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Hypoxic preconditioning involves system Xc− regulation in mouse neural stem cells

(2011) Brian Sims et al.   Stem Cell Research

New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis

(2010) Yan Wang et al.   JOURNAL OF HEPATOLOGY

Reduced liver fibrosis in hypoxia-inducible factor-1α-deficient mice

(2009) Jeon-OK Moon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY