Article
Clinical Neurology
Chen Wang, Verena Boerger, Ayan Mohamud Yusuf, Tobias Tertel, Oumaima Stambouli, Florian Murke, Nico Freund, Christoph Kleinschnitz, Josephine Herz, Matthias Gunzer, Aurel Popa-Wagner, Thorsten R. Doeppner, Bernd Giebel, Dirk M. Hermann
Summary: This study demonstrates the neuroprotective and anti-inflammatory effects of MSC-sEVs in aged mice after ischemia, which can reduce neurological deficits, infarct volume, brain edema, neuronal injury, and the infiltration of leukocytes in the brain, as well as decrease the number of monocytes and activated T cells in peripheral blood.
Article
Geriatrics & Gerontology
ZhaoLei Ma, Chun-Feng Liu, Li Zhang, Ning Xiang, Yifan Zhang, Lan Chu
Summary: This study analyzed the distribution of immune cells in AIS patients using the CIBERSORT algorithm and identified 52 intersection genes between target genes and disease genes. By further analyzing the correlation between these genes and immune cells, it was found that 4 circRNAs were positively correlated with neutrophils. These findings suggest a potential regulatory relationship between circRNA-mediated ceRNA and the immune mechanism in AIS.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Grant P. Higerd-Rusli, Sidharth Tyagi, Christopher A. Baker, Shujun Liu, Fadia B. Dib-Hajj, Sulayman D. Dib-Hajj, Stephen G. Waxman
Summary: Inflammation causes pain by altering the ionic currents in nociceptors, resulting in increased excitability. NaV1.7 and KV7.2 channels play opposing roles in nociceptor excitability. This study used live-cell imaging to investigate the mechanisms by which inflammatory mediators regulate the abundance of these channels at axonal surfaces. The results revealed a cell biological mechanism for inflammatory pain and suggested NaV1.7 trafficking as a potential therapeutic target.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Cell Biology
Uzma Saqib, Sreepadaarchana Munjuluri, Sutripta Sarkar, Subir Biswas, Oyshi Mukherjee, Hargopal Satsangi, Mirza S. S. Baig, Alexander G. G. Obukhov, Krishnan Hajela
Summary: The TRPC subfamily of mammalian Transient Receptor Potential Canonical channels consists of seven transmembrane proteins that form cation channels in mammalian cell plasma membranes. TRPC channels mediate the influx of Ca2+ and Na+ into cells. Deficiency or increased activity of TRPC6 has been linked to various diseases, including kidney disease, pulmonary disease, and neurological disease. This review summarizes the progress made in investigating the physiological roles of TRPC6 and the development of pharmacological tools to modulate its activity.
Article
Biochemistry & Molecular Biology
Charles Bengtson, Neerupma Silswal, Nathalie Baumlin, Makoto Yoshida, John Dennis, Sireesha Yerrathota, Michael Kim, Matthias Salathe
Summary: This study explored the effects of the CFTR amplifier nesolicaftor on CFTR function and ciliary beating in an inflammatory environment, demonstrating that nesolicaftor can enhance the response of F508del CFTR to the modulator ETI, and reverse the effects of TGF-beta 1 on CFTR function and cytokine expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Hematology
Suhair Abdeen, Rami Abu-Fanne, Khalil Bdeir, Emad Maraga, Mohamed Higazi, Douglas B. Cines, Samuel N. Heyman, Abd Al-Roof Higazi
Summary: In patients with severe COVID-19, treatment with Tocilizumab (TCZ) led to an increase in interleukin-6 (IL-6), alpha-Defensin, and D-dimers, while colchicine reduced alpha-Defensin and D-dimer levels. This suggests that TCZ and colchicine have diverse effects on D-dimer levels in COVID-19 patients.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Lei Zhang, Chenyang Zhang, Xin Dong, Zeyuan Dong
Summary: In this study, artificial supramolecular lithium channels composed of pore-containing small aromatic molecules were developed for the treatment of psychiatric disorders. These channels showed unprecedented transmembrane transport of exogenous lithium ions with high selectivity. The discovery of the basic requirements for ion transport function in these channels may have important implications in studying the physiological role of intracellular lithium ions and treating psychiatric disorders.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Biomedical
Lais Morandini, Derek Avery, Benjamin Angeles, Paul Winston, Rebecca K. Martin, Henry J. Donahue, Rene Olivares-Navarrete
Summary: Neutrophils play a crucial role in the immune response to biomaterial implantation by releasing cytokines, chemokines, and DNA-based networks called NETs. In this study, we found that inhibiting NET formation suppresses pro-inflammatory macrophage activation and accelerates the inflammatory phase of healing, leading to greater bone formation around the implanted biomaterial. These findings highlight the importance of the neutrophil response and innate immune cell regulation during the integration of biomaterials.
ACTA BIOMATERIALIA
(2023)
Article
Immunology
Wiebke Nadolni, Roland Immler, Kilian Hoelting, Marco Fraticelli, Myriam Ripphahn, Simone Rothmiller, Masayuki Matsushita, Ingrid Boekhoff, Thomas Gudermann, Markus Sperandio, Susanna Zierler
Summary: The study demonstrates the functional expression of TRPM7 in neutrophils and its impact on neutrophil recruitment during inflammation. Blocking TRPM7 channel or kinase activity affects neutrophil function, indicating a potential target to treat excessive neutrophil invasion.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Anna Selezneva, Alasdair J. Gibb, Dean Willis
Summary: The traditional view of the nuclear envelope as an inert physical barrier has been challenged by recent research, which suggests that it plays important roles in regulating cellular functions, particularly in immune cells. The nuclear envelope may serve as a sensor/transducer of mechanical signals and an integrator of mechanical and chemical signals, allowing precise regulation of gene transcription and functionality in immune cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Yuan Qu, Yang Fu, Yuan Liu, Chuanguo Liu, Bing Xu, Qian Zhang, Ping Jiang
Summary: Transient receptor potential cation channel subfamily V member 1 (TRPV1) has been found to play a role in immune regulation and its dysregulation affects the development of rheumatoid arthritis. Understanding the mechanism of TRPV1 can lead to the design of new drugs and improved treatment of RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Congqin Li, Ying Xing, Yuqian Zhang, Yan Hua, Jian Hu, Yulong Bai
Summary: Most acute strokes are ischemic, leading to subsequent neuroinflammation that promotes further damage but also serves a beneficial role. Neutrophils play a key role after ischemic stroke, with increasing evidence showing their involvement in the pathogenic process through the release of NETs.
MOLECULAR NEUROBIOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Ioana Stejerean-Todoran, Ivan Bogeski
Summary: Recent research reveals a crucial role of Na+ leak channel NALCN in metastatic prostate cancer, as it promotes metastasis by regulating Ca2+ signaling. This finding contributes to our understanding of the involvement of ion channels in cancer cell biology.
Review
Hematology
Junaid Ansari, Felicity N. E. Gavins
Summary: This article highlights the pathophysiological role of neutrophils in stroke and discusses ongoing pharmacotherapeutic strategies focusing on potential therapeutic targets for enhancing neuroprotection, mitigating inflammatory pathways, and enabling resolution. Neutrophils play a critical role in neuroinflammatory responses, driving either inflammatory or anti-inflammatory/pro-resolution effects depending on the underlying vascular state.
Review
Cell Biology
Yun-Chang Wang, Yu-Bao Lu, Xiao-Lan Huang, Yong-Feng Lao, Lu Zhang, Jun Yang, Mei Shi, Hai-Long Ma, Ya-Wen Pan, Yi-Nian Zhang
Summary: Myeloperoxidase plays an important role in the occurrence and development of stroke. It can be used for the evaluation and prognosis of stroke, and inhibiting myeloperoxidase has positive impacts on stroke prognosis.
NEURAL REGENERATION RESEARCH
(2022)
Article
Clinical Neurology
Thomas Grueter, Franziska E. Moellers, Anja Tietz, Justina Dargvainiene, Nico Melzer, Anna Heidbreder, Christine Strippel, Andrea Kraft, Romana Hoeftberger, Florian Schoeberl, Franziska S. Thaler, Jonathan Wickel, Ha-Yeun Chung, Frank Seifert, Marlene Tschernatsch, Michael Nagel, Jan Lewerenz, Sven Jarius, Brigitte C. Wildemann, Lucie de Azevedo, Fedor Heidenreich, Raphaela Heusgen, Ulrich Hofstadt-van Oy, Andreas Linsa, Jannis Justus Maass, Til Menge, Marius Ringelstein, David J. Pedrosa, Josef Schill, Thomas Seifert-Held, Caspar Seitz, Silke Tonner, Christian Urbanek, Simone Zittel, Robert Markewitz, Mirjam Korporal-Kuhnke, Thomas Schmitter, Carsten Finke, Norbert Brueggemann, Corinna Bien, Ingo Kleiter, Ralf Gold, Klaus-Peter Wandinger, Gregor Kuhlenbaeumer, Frank Leypoldt, Ilya Ayzenberg
Summary: In a study of a large group of anti-IgLON5 disease patients, Gruter et al. found that early inflammatory CSF changes, subacute relapses, and HLA-DRB1*10:01 were associated with higher autoantibody levels, supporting the autoimmune nature of the disease. They also found that immunotherapy is effective if initiated early, before major neurodegeneration occurs.
Review
Biochemistry & Molecular Biology
Marvin Korff, Ruben Steigerwald, Elena Bechthold, Dirk Schepmann, Julian A. Schreiber, Sven G. Meuth, Guiscard Seebohm, Bernhard Wuensch
Summary: GluN2B-NMDA receptors play a key role in neurological and neurodegenerative disorders. A new GluN2B-NMDA receptor modulator was developed with promising affinity and pharmacological activity, which could be suitable for human application.
BIOLOGICAL CHEMISTRY
(2023)
Article
Neurosciences
Olga Holtmann, Insa Schlossmacher, Marcel Franz, Constanze Moenig, Jan-Gerd Tenberge, Christoph Preul, Wolfram Schwindt, Maximilian Bruchmann, Nico Melzer, Wolfgang H. R. Miltner, Thomas Straube
Summary: The insula plays a central role in empathy, but the complex structure of cognitive and affective empathy deficits following insular damage is not fully understood. In this study, patients with insular lesions and healthy controls viewed videos to assess their empathic responses. The results showed that patients differed from controls only in negative affective empathy, rating their own affective state less negative than the target. This deficit was independent of other factors and may be due to intact interpretation of social context by residual networks outside the lesion.
Article
Endocrinology & Metabolism
Theresia Sarabhai, Lucia Mastrototaro, Sabine Kahl, Gidon J. Boenhof, Marc Jonuscheit, Pavel Bobrov, Hisayuki Katsuyama, Rainer Guthoff, Martin Wolkersdorfer, Christian Herder, Sven G. Meuth, Sven Dreyer, Michael Roden
Summary: This study aimed to examine the effects of hyperbaric oxygen therapy on whole-body glucose metabolism in individuals with type 2 diabetes. The results showed that hyperbaric oxygen therapy decreased fasting blood glucose, improved whole-body insulin sensitivity, and achieved this improvement through decreasing endoplasmic reticulum stress and increasing mitochondrial function.
Article
Cardiac & Cardiovascular Systems
A. G. Bejinariu, M. Schilling, P. Mueller, L. Clasen, S. Gerguri, S. Angendohr, S. Katsianos, J. Schmidt, C. Brinkmeyer, S. G. Meuth, M. Kelm, H. Makimoto
Summary: The total atrial conduction time (TACT) measured by echocardiography can predict the risk of atrial fibrillation (AF) and stroke; adding TACT to the revised Framingham stroke risk profile (rFSRP) significantly improves the prediction of stroke incidence.
Article
Clinical Neurology
Harald Hefter, Dietmar Rosenthal, Alexander Jansen, Raphaela Brauns, Beyza Urer, Hans Bigalke, Hans-Peter Hartung, Sven G. Meuth, John-Ih Lee, Philipp Albrecht, Sara Samadzadeh
Summary: The study found that frequent injections of a complex protein-containing BoNT/A preparation are associated with a significantly higher risk of developing neutralizing antibodies (NABs) compared to injections with a complex protein-free BoNT/A preparation.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Yvonne Reiss, Sebastian Bauer, Bastian David, Kavi Devraj, Elif Fidan, Elke Hattingen, Stefan Liebner, Nico Melzer, Sven G. Meuth, Felix Rosenow, Theodor Rueber, Laurent M. Willems, Karl H. Plate
Summary: The blood-brain barrier (BBB) is a crucial physiological barrier that maintains the brain microenvironment necessary for proper neuronal function. Dysfunction of the BBB is a characteristic of neurological diseases including ischemia, brain tumors, neurodegenerative diseases, infections, and autoimmune neuroinflammatory disorders. Additionally, BBB dysfunction is involved in epilepsy, a brain disorder characterized by synchronized neuronal activity and seizures. While antiseizure drugs targeting neuronal hyperexcitability are not always effective, drugs specifically targeting the neurovasculature in epilepsy patients have not been explored. Understanding the mechanism of BBB compromise in epilepsy is important for its therapeutic potential.
Review
Clinical Neurology
Christoph Mueller, Saskia Elben, Gregory S. Day, Pedro Alves, Julien Hebert, David F. Tang-Wai, Olga Holtmann, Raffaele Iorio, Daniela Perani, Maarten J. Titulaer, Niels Hansen, Thorsten Bartsch, Andreas Johnen, Zslot Illes, Leah Borm, Alice G. Willison, Heinz Wiendl, Sven G. Meuth, Stjepana Kovac, Jens Boelte, Nico Melzer
Summary: This study aims to investigate whether autoimmune limbic encephalitis (ALE) with different associated autoantibodies (AABs) exhibit distinct neuropsychological manifestations and respond differently to immunotherapy. The results show that ALE patients with AABs against LGI1, CASPR2, and GAD65 commonly have memory deficits, along with deficits in attention, executive functions, and psychological function. However, there is currently no definite evidence supporting the notion that different AAB-types of ALE have distinct neuropsychological manifestations and respond differently to immunotherapy.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Biochemistry & Molecular Biology
Christina B. Schroeter, Christopher Nelke, Marcus Schewe, Lucas Spohler, Alexander M. Herrmann, Thomas Muentefering, Niklas Huntemann, Maria Kuzikov, Philip Gribbon, Sarah Albrecht, Stefanie Bock, Petra Hundehege, Lea Christine Neelsen, Thomas Baukrowitz, Guiscard Seebohm, Bernhard Wuensch, Stefan Bittner, Tobias Ruck, Thomas Budde, Sven G. Meuth
Summary: This study identifies and validates three new activators of TREK1 channel, namely E1, B3, and A2. These compounds reduce levels of adhesion molecules on human brain and muscle endothelial cells without affecting cell viability. Among them, A2 has the strongest effect on adhesion molecules but lacks TREK1 activation in neuronal cells. This study provides new activators that might be employed to pharmacologically modulate TREK1 activity.
BIOLOGICAL CHEMISTRY
(2023)
Article
Neurosciences
Kira Engeroff, Davide Warm, Stefan Bittner, Oriane Blanquie
Summary: Reelin is a large extracellular matrix protein that plays important roles in the development of the neocortex. It is mainly secreted by Cajal-Retzius neurons during the embryonic and early postnatal stages in mice. In this study, the researchers investigated the expression and secretion of Reelin in the neocortex, and found that electrical activity and neuronal network silencing differentially regulate Reelin synthesis and its subsequent actions. These findings contribute to a better understanding of the mechanisms underlying Reelin regulation.
Article
Clinical Neurology
Lauranne Scheldeman, Anke Wouters, Jeroen Bertels, Patrick Dupont, Bastian Cheng, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Christian Gerloff, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z. Simonsen, Vincent Thijs, Goetz Thomalla, Robin Lemmens
Summary: The study aims to investigate the reversibility of diffusion-weighted imaging (DWI) lesions and its association with thrombolysis, reperfusion, and functional outcomes. It found that reversibility of DWI lesions is common in patients from the WAKE-UP trial, and it is more pronounced after thrombolysis.
Article
Medical Laboratory Technology
David Wilson, Dandan Chan, Lei Chang, Robert Mathis, Inge Verberk, Xavier Montalban, Manuel Comabella, Nicolas Fissolo, Bibi Bielekova, Ruturaj Masvekar, Tanuja Chitnis, Tjalf Ziemssen, Katja Akguen, Kaj Blennow, Henrik Zetterberg, Wolfgang Brueck, Gavin Giovannoni, Sharmilee Gnanapavan, Stefan Bittner, Frauke Zipp, Giancarlo Comi, Roberto Furlan, Sylvain Lehmann, Simon Thebault, Mark Freedman, Amit Bar-Or, Marty Kramer, Markus Otto, Steffen Halbgebauer, Kevin Hrusovsky, Tatiana Plavina, Michael Khalil, Fredrik Piehl, Heinz Wiendl, Ludwig Kappos, Aleksandra Maceski, Eline Willemse, David Leppert, Charlotte Teunissen, Jens Kuhle
Summary: A fully automated digital immunoassay for measuring neurofilament light chain (NfL) in serum has been developed and validated across multiple centers. This assay shows high sensitivity, reproducibility, and automation, making it suitable for clinical use in assessing and monitoring axonal injury.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Katharina J. Wenger, Maya C. Hoelter, Yavor Yalachkov, Jan Hendrik Schaefer, Dilek Oezkan, Falk Steffen, Stefan Bittner, Elke Hattingen, Christian Foerch, Martin A. Schaller-Paule
Summary: This study examined the correlation between total brain T2 lesion volume or lesion number and serum and cerebrospinal fluid (CSF) biomarkers in MS patients. The results showed a stronger association between T2 lesion volume and serum NfL compared to T2 lesion number and serum NfL. There was a moderate positive relationship between CSF NfL and both T2 lesion number and volume. No significant association was found between MRI markers and GFAP levels.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Review
Cell Biology
Andreu Matamoros-Angles, Behnam Mohammadi, Feizhi Song, Mohsin Shafiq, Santra Brenna, Berta Puig, Markus Glatzel, Hermann Altmeppen
Summary: The role of prion protein in neurodegenerative diseases, including prion diseases and common brain disorders like Alzheimer's disease and Parkinson's disease, has been extensively studied. The misfolding and spreading of prion protein, as well as its interactions with other proteins, contribute to the development of these fatal and transmissible brain diseases. However, our understanding of the pathological and physiological roles of prion protein is still incomplete.
NEURAL REGENERATION RESEARCH
(2023)
Article
Medicine, General & Internal
Jordi Kuehne Escola, Bessime Bozkurt, Bastian Brune, Woon Hyung Chae, Lennart Steffen Milles, Doreen Pommeranz, Lena Brune, Philipp Dammann, Ulrich Sure, Cornelius Deuschl, Michael Forsting, Clemens Kill, Christoph Kleinschnitz, Martin Koehrmann, Benedikt Frank
Summary: Stroke mimics are common in the emergency department, and early detection is crucial for initiating appropriate treatment. This study compared the frequency, clinical characteristics, and predictors of non-neurological and neurological stroke mimics in patients with suspected stroke. The results highlighted the importance of awareness of underlying etiologies and differences in clinical characteristics for optimal care.
JOURNAL OF CLINICAL MEDICINE
(2023)