Article
Biochemistry & Molecular Biology
Michael Birk, Ewa Baum, Jenia Kouchek Zadeh, Caroline Manicam, Norbert Pfeiffer, Andreas Patzak, Johanna Helmstaedter, Sebastian Steven, Marin Kuntic, Andreas Daiber, Adrian Gericke
Summary: The study found that Ang II may induce endothelial dysfunction in mouse ophthalmic arteries via AT1R activation and NOX2-dependent ROS formation. Blocking AT1R signaling and/or NOX2 may be helpful in maintaining or restoring endothelial function in ocular blood vessels in certain ocular diseases.
Article
Biochemistry & Molecular Biology
Dezhen Tu, Ravikanth Velagapudi, Yun Gao, Jau-Shyong Hong, Hui Zhou, Hui-Ming Gao
Summary: This study investigates the expression patterns, regulatory mechanisms, and pathological roles of neuronal NADPH oxidase in inflammation-associated neurodegeneration. The results show that NOX2 is persistently upregulated in neurons during chronic neuroinflammation and is associated with oxidative stress and neurodegeneration. Inhibition of neuronal NOX2 can block the degenerative effects of inflammatory mediators and prevent neurodegeneration.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Endocrinology & Metabolism
Yuying Guan, Yakun Gu, Haitao Shao, Wei Ma, Gaifen Li, Mengyuan Guo, Qianqian Shao, Yuning Li, Yingxia Liu, Chaoyu Wang, Zhengming Tian, Jia Liu, Xunming Ji
Summary: Ischemic stroke causes neurological damage due to blood vessel occlusion. This study found that intermittent hypoxia significantly improves cerebrovascular microcirculation and prevents ischemic stroke, while continuous hypoxia has no such effects.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Clinical Neurology
Michela Sforza, Edoardo Bianchini, Diletta Alivernini, Marco Salvetti, Francesco E. Pontieri, Giuliano Sette
Summary: The regulation of cerebral blood flow is essential for delivering oxygen and nutrients to the brain and removing metabolic wastes. Cerebral vasoreactivity refers to the ability of the nervous system to regulate blood flow based on metabolic demands. Studies have shown that impaired cerebral vasoreactivity is associated with cognitive impairment and cerebrovascular disorders. Understanding the alterations in cerebral vasoreactivity in acute and chronic cerebrovascular disorders and cognitive dysfunction could aid in improving treatment and rehabilitation strategies.
JOURNAL OF NEURAL TRANSMISSION
(2022)
Article
Endocrinology & Metabolism
Alessio Alfieri, Juraj Koudelka, Mosi Li, Sanny Scheffer, Jessica Duncombe, Andrea Caporali, Rajesh N. Kalaria, Colin Smith, Ajay M. Shah, Karen Horsburgh
Summary: Chronic microvascular inflammation and oxidative stress are important mechanisms underlying white matter disease and vascular cognitive impairment (VCI). Nox2 plays a critical role, and its genetic deletion can protect against white matter pathology and cognitive impairment. This study has clinical implications for the treatment of vascular diseases.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Clinical Neurology
David X. Zhao, Emma Gootee, Michelle C. Johansen
Summary: The study found an association between atrial cardiopathy and the presence of cerebral microbleeds in ischemic stroke patients, but not with the number of microbleeds.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cell Biology
Hao Wu, Ying Li, Qian Zhang, Hanxun Wang, Wenyu Xiu, Pu Xu, Yujie Deng, Wanxu Huang, Dan Ohtan Wang
Summary: This study demonstrates that crocetin, a natural antioxidant compound from saffron, antagonizes parthanatos in ischemic stroke. In the early stage of parthanatos, crocetin inhibits the activation of NOX2 to reduce the production of ROS and PAR. In the later stage of parthanatos, crocetin interacts with HK-I to prevent mitochondrial dysfunction and DNA damage, ultimately preventing irreversible cell death. This study supports the further development of crocetin as a potential drug candidate for preventing and/or treating ischemic stroke.
CELL DEATH & DISEASE
(2023)
Article
Clinical Neurology
Laurens Winkelmeier, Tobias D. Faizy, Gabriel Broocks, Lukas Meyer, Christian Heitkamp, Caspar Brekenfeld, Christian Thaler, Paul Steffen, Maximilian Schell, Milani Deb-Chatterji, Uta Hanning, Helge Kniep, Mate E. Maros, Goetz Thomalla, Jens Fiehler, Fabian Alexander Flottmann
Summary: The clinical benefit of endovascular therapy in patients with large ischemic stroke is associated with the number of recanalization attempts. At least 2 recanalization attempts improve the likelihood of favorable functional outcomes, while more than 2 attempts should be carefully assessed.
Article
Chemistry, Multidisciplinary
Lei Li, Jing-jing Song, Meng-xue Zhang, Hui-wen Zhang, Hai-yan Zhu, Wei Guo, Cai-long Pan, Xue Liu, Lu Xu, Zhi-yuan Zhang
Summary: This study demonstrates that oridonin has a protective effect against neuronal loss caused by ischemic stroke, and this protection is achieved by inhibiting excessive autophagy signaling pathway.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Hailong Yu, Xin Chen, Xin Guo, Danni Chen, Li Jiang, Yajie Qi, Jun Shao, Luhang Tao, Jing Hang, Guangyu Lu, Yingzhu Chen, Yuping Li
Summary: This study aimed to investigate the role of serum xanthine oxidase (XO) levels in the pathogenesis of acute ischemic stroke (AIS). The results showed that the serum level of XO was significantly higher in AIS patients compared to healthy controls and was an independent risk factor for AIS. Serum XO level also had predictive value for stroke progression and prognosis in AIS patients.
Article
Biochemistry & Molecular Biology
Cheng-Tien Wu, Man-Chih Chen, Shing-Hwa Liu, Ting-Hua Yang, Lin-Hwa Long, Siao-Syun Guan, Chang-Mu Chen
Summary: This study found that both ICA and ICT have neuroprotective effects in acute cerebral ischemic stroke mice, with ICT showing slightly better results than ICA. Pretreatment with both ICA and ICT improves neuronal cell apoptosis, responses to oxidative/nitrosative stress, and counteracts ECM accumulation in the brains of acute cerebral ischemic stroke mice.
Article
Biochemistry & Molecular Biology
Geon Ko, Jinho Kim, Yeong-Jae Jeon, Donghun Lee, Hyeon-Man Baek, Keun-A Chang
Summary: This study investigated the therapeutic mechanism of Salvia miltiorrhiza (SM) on stroke using a tMCAO mouse model. Results showed that SM administration significantly reduced acute brain injury, restored brain metabolites, inhibited ferroptosis, and alleviated synaptic and neuronal loss. Additionally, it improved neurological deficits, survival rates, and post-stroke cognitive impairment.
Review
Biochemistry & Molecular Biology
Malgorzata Szczuko, Igor Koziol, Dariusz Kotlega, Jacek Brodowski, Arleta Drozd
Summary: Cardiovascular diseases are leading causes of morbidity and mortality in developed countries, with ischemic stroke being a significant disorder. Acetylsalicylic acid (ASA) is a treatment modality that blocks cyclooxygenase, and measuring thromboxane B2 in serum is a potential biomarker of vascular disease risk. Further research is needed to determine the effectiveness of thromboxane as a clinical marker for ischemic stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Marina S. Hernandes, Qian Xu, Kathy K. Griendling
Summary: In this review, recent findings on the role of NADPH oxidases in BBB disruption induced by ischemic stroke were highlighted, emphasizing the impact of ROS on the function of the blood-brain barrier in neurological disorders.
Article
Clinical Neurology
Benjamin Beland, Fouzi Bala, Aravind Ganesh
Summary: A systematic review and meta-analysis found that patients with prestroke disability who received IVT treatment had better odds of returning to baseline function compared to those who did not receive treatment. There were no significant differences in mortality and sICH rates between treated and untreated patients with disability. Further high-quality data comparing treated and untreated patients with prestroke disability are needed to clarify the issue.
Article
Endocrinology & Metabolism
Megan A. Evans, Hyun Ah Kim, T. Michael De Silva, Thiruma V. Arumugam, Andrew N. Clarkson, Grant R. Drummond, Graeme R. Zosky, Brad Rs Broughton, Christopher G. Sobey
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2018)
Article
Hematology
Angelica Salas-Perdomo, Francesc Miro-Mur, Xabier Urra, Carles Justicia, Mattia Gallizioli, Yashu Zhao, Vanessa H. Brait, Carlos Laredo, Raul Tudela, Andres Hidalgo, Angel Chamorro, Anna M. Planas
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2018)
Article
Peripheral Vascular Disease
T. Michael De Silva, Mary L. Modrick, Fabrice Dabertrand, Frank M. Faraci
Article
Peripheral Vascular Disease
T. Michael De Silva, Ying Li, Dale A. Kinzenbaw, Curt D. Sigmund, Frank M. Faraci
Article
Neurosciences
Megan A. Evans, Hyun Ah Kim, Yeong Hann Ling, Sandy Uong, Antony Vinh, T. Michael De Silva, Thiruma V. Arumugam, Andrew N. Clarkson, Graeme R. Zosky, Grant R. Drummond, Brad R. S. Broughton, Christopher G. Sobey
NEUROMOLECULAR MEDICINE
(2018)
Article
Clinical Neurology
Megan A. Evans, Rebecca Lim, Hyun Ah Kim, Hannah X. Chu, Chantelle V. Gardiner-Mann, Kimberly W. E. Taylor, Christopher T. Chan, Vanessa H. Brait, Seyoung Lee, Quynh Nhu Dinh, Antony Vinh, Thanh G. Phan, Velandai K. Srikanth, Henry Ma, Thiruma V. Arumugam, David Y. Fann, Luting Poh, Cameron P. J. Hunt, Colin W. Pouton, John M. Haynes, Stavros Selemidis, William Kwan, Leon Teo, James A. Bourne, Silke Neumann, Sarah Young, Emma K. Gowing, Grant R. Drummond, Andrew N. Clarkson, Euan M. Wallace, Christopher G. Sobey, Brad R. S. Broughton
Article
Cardiac & Cardiovascular Systems
Vanessa H. Brait, Francesc Miro-Mur, Isabel Perez-de-Puig, Laura Notario, Begona Hurtado, Jordi Pedragosa, Mattia Gallizioli, Francesc Jimenez-Altayo, Maria Arbaizar-Rovirosa, Amaia Otxoa-de-Amezaga, Juan Monteagudo, Maura Ferrer-Ferrer, Xavier de la Rosa, Ester Bonfill-Teixidor, Angelica Salas-Perdomo, Alba Hernandez-Vidal, Pablo Garcia-de-Frutos, Pilar Lauzurica, Anna M. Planas
CIRCULATION RESEARCH
(2019)
Article
Multidisciplinary Sciences
Angelica Salas-Perdomo, Francesc Miro-Mur, Mattia Gallizioli, Vanessa H. Brait, Carles Justicia, Anja Meissner, Xabier Urra, Angel Chamorro, Anna M. Planas
SCIENTIFIC REPORTS
(2019)
Letter
Public, Environmental & Occupational Health
Vanessa Helena Brait
JOURNAL OF PUBLIC HEALTH
(2020)
Article
Cell Biology
Mattia Gallizioli, Francesc Miro-Mur, Amaia Otxoa-de-Amezaga, Roger Cugota, Angelica Salas-Perdomo, Carles Justicia, Vanessa H. Brait, Francisca Ruiz-Jaen, Maria Arbaizar-Rovirosa, Jordi Pedragosa, Ester Bonfill-Teixidor, Mathias Gelderblom, Tim Magnus, Eva Cano, Carlos del Fresno, David Sancho, Anna M. Planas
Article
Multidisciplinary Sciences
Vanessa H. Brait, David K. Wright, Mohsen Nategh, Alexander Oman, Warda T. Syeda, Charlotte M. Ermine, Katrina R. O'Brien, Emilio Werden, Leonid Churilov, Leigh A. Johnston, Lachlan H. Thompson, Jess Nithianantharajah, Katherine A. Jackman, Amy Brodtmann
Summary: Research on mice has shown changes in hippocampal volume after stroke, particularly in areas containing direct infarction, where there is a decrease in infarcted tissue volume and an increase in non-infarcted tissue volume. These findings provide new insights into understanding the changes that occur in the hippocampus after a stroke.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
T. Michael De Silva, Mary L. Modrick, Justin L. Grobe, Frank M. Faraci
Summary: The activation of central and cerebrovascular RAS impairs endothelial signaling in the brain through AT1R expression and activation, leading to impaired cerebral artery function and showing sex-dependent effects.
Article
Neurosciences
Charlotte M. Ermine, Jess Nithianantharajah, Katrina O'Brien, Jessica A. Kauhausen, Stefano Frausin, Alexander Oman, Mark W. Parsons, Vanessa H. Brait, Amy Brodtmann, Lachlan H. Thompson
Summary: Animal modeling has been crucial in understanding the pathobiology of stroke. This research highlights the importance of addressing progressive atrophy and chronic inflammation as additional targets for intervention in the chronic phase after injury, even in cases of mild ischemic insult.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Behavioral Sciences
Vanessa H. Brait, Katherine A. Jackman, Terence Y. Pang
Summary: Stroke is a major cause of mortality, and the treatment process is complicated by the emergence of secondary psychological symptoms. Selective serotonin reuptake inhibitors (SSRIs) have been effective in treating poststroke depression (PSD), but alternative treatment options need to be explored due to the associated risks. Exercise has shown mood benefits in neurological conditions, but the effects of physical exercise post-stroke are not well-known.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Cell Biology
Quynh Nhu Dinh, Grant R. Drummond, Barbara K. Kemp-Harper, Henry Diep, T. Michael De Silva, Hyun Ah Kim, Antony Vinh, Avril A. B. Robertson, Matthew A. Cooper, Ashley Mansell, Sophocles Chrissobolis, Christopher G. Sobey