A Proteomic Perspective of Sirtuin 6 (SIRT6) Phosphorylation and Interactions and Their Dependence on Its Catalytic Activity

SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair

(2016) Ronald A. McCord et al.   Aging-US

Heterogeneity in the properties of NEFL mutants causing Charcot–Marie–Tooth disease results in differential effects on neurofilament assembly and susceptibility to intervention by the chaperone-inducer, celastrol

(2013) Benoit J. Gentil et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

(2013) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals

(2013) M. Jedrusik-Bode et al.   JOURNAL OF CELL SCIENCE

Sirtuin 6: a review of biological effects and potential therapeutic properties

(2013) Jade M. Beauharnois et al.   Molecular BioSystems

The functional interactome landscape of the human histone deacetylase family

(2013) P. Joshi et al.   Molecular Systems Biology

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

(2013) Hong Jiang et al.   NATURE

Sirtuin 6 protects cardiomyocytes from hypertrophyin vitrovia inhibition of NF-κB-dependent transcriptional activity

(2012) Shan-Shan Yu et al.   BRITISH JOURNAL OF PHARMACOLOGY

DNA Sequence-Dependent Compartmentalization and Silencing of Chromatin at the Nuclear Lamina

(2012) Joseph M. Zullo et al.   CELL

Seven sirtuins for seven deadly diseases ofaging

(2012) Brian J. Morris   FREE RADICAL BIOLOGY AND MEDICINE

Aurora B-dependent Regulation of Class IIa Histone Deacetylases by Mitotic Nuclear Localization Signal Phosphorylation

(2012) Amanda J. Guise et al.   MOLECULAR & CELLULAR PROTEOMICS

Functional Proteomics Establishes the Interaction of SIRT7 with Chromatin Remodeling Complexes and Expands Its Role in Regulation of RNA Polymerase I Transcription

(2012) Yuan-Chin Tsai et al.   MOLECULAR & CELLULAR PROTEOMICS

Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging

(2012) Gaoxiang Jia et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Over Expression of Wild Type or a Catalytically Dead Mutant of SIRTUIN 6 Does Not Influence NFκB Responses

(2012) Rachel Grimley et al.   PLoS One

Identification of Novel Interacting Partners of Sirtuin6

(2012) Oxana Polyakova et al.   PLoS One

Deubiquitination of NF- B by Ubiquitin-Specific Protease-7 promotes transcription

(2012) A. Colleran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of stress granule assembly in Schizosaccharomyces pombe

(2012) C.-Y. Wang et al.   RNA

BCLAF1 is a radiation-induced H2AX-interacting partner involved in γH2AX-mediated regulation of apoptosis and DNA repair

(2012) Y Y Lee et al.   Cell Death & Disease

Structures, Substrates, and Regulators of Mammalian Sirtuins – Opportunities and Challenges for Drug Development

(2012) Sébastien Moniot et al.   Frontiers in Pharmacology

Regulation of Sirtuin Function by Posttranslational Modifications

(2012) Franziska Flick et al.   Frontiers in Pharmacology

Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6

(2011) Eriko Michishita et al.   CELL CYCLE

The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability

(2011) Bo Yang et al.   CELL CYCLE

Sirtuins: Multifaceted Drug Targets

(2011) S. P. Chakrabarty et al.   CURRENT MOLECULAR MEDICINE

Structure and Biochemical Functions of SIRT6

(2011) Patricia W. Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coilin participates in the suppression of RNA polymerase I in response to cisplatin-induced DNA damage

(2011) Andrew S. Gilder et al.   MOLECULAR BIOLOGY OF THE CELL

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

System-Wide Temporal Characterization of the Proteome and Phosphoproteome of Human Embryonic Stem Cell Differentiation

(2011) K. T. G. Rigbolt et al.   Science Signaling

SIRT6 is required for maintenance of telomere position effect in human cells

(2011) Ruth I. Tennen et al.   Nature Communications

Dynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging-Related Transcriptional Networks

(2011) Tiara L. A. Kawahara et al.   PLoS Genetics

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Cytoscape 2.8: new features for data integration and network visualization

(2010) M. E. Smoot et al.   BIOINFORMATICS

Chromatin-Bound Nuclear Pore Components Regulate Gene Expression in Higher Eukaryotes

(2010) Maya Capelson et al.   CELL

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis

(2010) Hyun-Seok Kim et al.   Cell Metabolism

Protein binding specificity versus promiscuity

(2010) Gideon Schreiber et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Functional proteomic analysis of promyelocytic leukaemia nuclear bodies in irradiation-induced MCF-7 cells

(2010) Jinfeng Liu et al.   JOURNAL OF BIOCHEMISTRY

Functional dissection of SIRT6: Identification of domains that regulate histone deacetylase activity and chromatin localization

(2010) Ruth I. Tennen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Nuclear Import of Histone Deacetylase 5 by Requisite Nuclear Localization Signal Phosphorylation

(2010) Todd M. Greco et al.   MOLECULAR & CELLULAR PROTEOMICS

SAINT: probabilistic scoring of affinity purification–mass spectrometry data

(2010) Hyungwon Choi et al.   NATURE METHODS

Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation

(2010) Abderrahmane Kaidi et al.   SCIENCE

Chromatin regulation and genome maintenance by mammalian SIRT6

(2010) Ruth I. Tennen et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Nuclear Pore Complex and Nuclear Transport

(2010) S. R. Wente et al.   Cold Spring Harbor Perspectives in Biology

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis

(2009) A. Grob et al.   JOURNAL OF CELL SCIENCE

Resolving the composition of protein complexes using a MALDI LTQ orbitrap

(2009) Yang Luo et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation

(2009) Sebastian Greiss et al.   MOLECULES AND CELLS

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

Universal sample preparation method for proteome analysis

(2009) Jacek R Wiśniewski et al.   NATURE METHODS

CK2 Is the Regulator of SIRT1 Substrate-Binding Affinity, Deacetylase Activity and Cellular Response to DNA-Damage

(2009) Hyeog Kang et al.   PLoS One

JNK1 Phosphorylates SIRT1 and Promotes Its Enzymatic Activity

(2009) Nargis Nasrin et al.   PLoS One

Sirtuins: Novel targets for metabolic disease in drug development

(2008) Wei-jian Jiang   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of Cyclin D1 RNA Stability by SNIP1

(2008) C. P. Bracken et al.   CANCER RESEARCH

Regulation of SIRT6 protein levels by nutrient availability

(2008) Yariv Kanfi et al.   FEBS LETTERS

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

(2008) T. Dechat et al.   GENES & DEVELOPMENT

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE

Sirtuins — novel therapeutic targets to treat age-associated diseases

(2008) Siva Lavu et al.   NATURE REVIEWS DRUG DISCOVERY

Phosphorylation Regulates SIRT1 Function

(2008) Tsutomu Sasaki et al.   PLoS One

A quantitative atlas of mitotic phosphorylation

(2008) N. Dephoure et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA