期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 39, 期 -, 页码 451-455出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0390451
关键词
cancer; mammalian target of rapamycin inhibitor (mTOR inhibitor); phosphoinositide 3-kinase (PI3K); rapalogue; targeted therapy
Substantial drug discovery efforts have been devoted, over the last few years, to identifying and developing mTOR (mammalian target of rapamycin) kinase modulators. This has resulted in a number of mTOR inhibitors with different mechanisms of action and/or distinct protein and lipid kinase selectivity profiles. As briefly reviewed in the present paper, these compounds have provided us with a better understanding of the roles of mTOR and other phosphoinositide 3-kinase/mTOR pathway components in human cancer biology, and a few of them have already demonstrated clinical benefit in cancer patients.
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