Mechanistic perspectives of calorie restriction on vascular homeostasis

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle

(2016) Orsolya M. Palacios et al.   Aging-US

SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice

(2016) Sokrates Stein et al.   Aging-US

Regulation of energy metabolism by inflammation: A feedback response in obesity and calorie restriction

(2016) Jianping Ye et al.   Aging-US

SIRT1 and SIRT3 Deacetylate Homologous Substrates: AceCS1,2 and HMGCS1,2

(2016) Matthew D. Hirschey et al.   Aging-US

Sirtuin 1 stabilization by HuR represses TNF-α- and glucose-induced E-selectin release and endothelial cell adhesivenessin vitro: relevance to human metabolic syndrome

(2014) Giulio Ceolotto et al.   CLINICAL SCIENCE

Adenosine 5'-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype

(2014) D. Sag et al.   JOURNAL OF IMMUNOLOGY

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Increased Metabolite Levels of Glycolysis and Pentose Phosphate Pathway in Rabbit Atherosclerotic Arteries and Hypoxic Macrophage

(2014) Atsushi Yamashita et al.   PLoS One

The Involvement of NFAT Transcriptional Activity Suppression in SIRT1-Mediated Inhibition of COX-2 Expression Induced by PMA/Ionomycin

(2014) Yu-Yan Jia et al.   PLoS One

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

(2014) Ricki J. Colman et al.   Nature Communications

Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice

(2013) Anthony J. Donato et al.   AGING CELL

Rapamycin Reverses Pulmonary Artery Smooth Muscle Cell Proliferation in Pulmonary Hypertension

(2013) Amal Houssaini et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Sirtuin 3 Deficiency Does Not Augment Hypoxia-Induced Pulmonary Hypertension

(2013) Gregory B. Waypa et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

SirT1 Regulation of Antioxidant Genes Is Dependent on the Formation of a FoxO3a/PGC-1α Complex

(2013) Yolanda Olmos et al.   ANTIOXIDANTS & REDOX SIGNALING

Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development

(2013) Stephan Winnik et al.   BASIC RESEARCH IN CARDIOLOGY

Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1

(2013) Gnanapragasam Arunachalam et al.   BRITISH JOURNAL OF PHARMACOLOGY

AMPKα1 Regulates Macrophage Skewing at the Time of Resolution of Inflammation during Skeletal Muscle Regeneration

(2013) Rémi Mounier et al.   Cell Metabolism

Calorie restriction and sirtuins revisited

(2013) L. Guarente   GENES & DEVELOPMENT

The Protective Effect of Fenofibrate Against TNF-α-Induced CD40 Expression through SIRT1-Mediated Deacetylation of NF-κB in Endothelial Cells

(2013) Weirong Wang et al.   INFLAMMATION

Enhanced activation of NAD(P)H

(2013) Yong-Hoon Kim et al.   JOURNAL OF HYPERTENSION

Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice

(2013) Peng Gao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways

(2013) M. J. Rardin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dyslipidemia in Obesity: Mechanisms and Potential Targets

(2013) Boudewijn Klop et al.   Nutrients

Effect of everolimus on pre-existing atherosclerosis in LDL-receptor deficient mice

(2012) Frank Beutner et al.   ATHEROSCLEROSIS

2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside ameliorates vascular senescence and improves blood flow involving a mechanism of p53 deacetylation

(2012) Xin Han et al.   ATHEROSCLEROSIS

SIRT1 deacetylates RFX5 and antagonizes repression of collagen type I (COL1A2) transcription in smooth muscle cells

(2012) Jun Xia et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice

(2012) Vladimir N. Anisimov et al.   CELL CYCLE

High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction

(2012) Angeliki Chalkiadaki et al.   Cell Metabolism

Metabolic Regulation of Epigenetics

(2012) Chao Lu et al.   Cell Metabolism

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Vascular Smooth Muscle Cell Sirtuin 1 Protects Against DNA Damage and Inhibits Atherosclerosis

(2012) Isabelle Gorenne et al.   CIRCULATION

Overexpression of Endothelial Nitric Oxide Synthase Prevents Diet-Induced Obesity and Regulates Adipocyte Phenotype

(2012) Brian E. Sansbury et al.   CIRCULATION RESEARCH

Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome

(2012) Alexander S. Hebert et al.   MOLECULAR CELL

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

(2012) Julie A. Mattison et al.   NATURE

Activation of AMP-activated protein kinase α2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo

(2012) Shuangxi Wang et al.   NATURE MEDICINE

Sirtuins mediate mammalian metabolic responses to nutrient availability

(2012) Angeliki Chalkiadaki et al.   Nature Reviews Endocrinology

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

Omega-3 Polyunsaturated Fatty Acids Antagonize Macrophage Inflammation via Activation of AMPK/SIRT1 Pathway

(2012) Bingzhong Xue et al.   PLoS One

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Cardiovascular Disease and mTOR Signaling

(2012) Zhao Zhong Chong et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Effects of Rhein Lysinate on H2O2-induced cellular senescence of human umbilical vascular endothelial cells

(2011) Ya-jun Lin et al.   ACTA PHARMACOLOGICA SINICA

Sirtuin 1 Retards Hyperphosphatemia-Induced Calcification of Vascular Smooth Muscle Cells

(2011) Aya Takemura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans)

(2011) Mikhail V Blagosklonny   CELL CYCLE

AMPKα2 Deletion Exacerbates Neointima Formation by Upregulating Skp2 in Vascular Smooth Muscle Cells

(2011) Ping Song et al.   CIRCULATION RESEARCH

SIRT1 Acts as a Modulator of Neointima Formation Following Vascular Injury in Mice

(2011) Li Li et al.   CIRCULATION RESEARCH

Repression of P66Shc Expression by SIRT1 Contributes to the Prevention of Hyperglycemia-Induced Endothelial Dysfunction

(2011) Shuang Zhou et al.   CIRCULATION RESEARCH

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Oxidative stress and endothelial dysfunction in hypertension

(2011) Eberhard Schulz et al.   HYPERTENSION RESEARCH

Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

(2011) Sandra Galic et al.   JOURNAL OF CLINICAL INVESTIGATION

Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling

(2011) Wenjing Guo et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Sirt3 Promotes the Urea Cycle and Fatty Acid Oxidation during Dietary Restriction

(2011) William C. Hallows et al.   MOLECULAR CELL

Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase

(2011) Virginia Guarani et al.   NATURE

Atherosclerosis: current pathogenesis and therapeutic options

(2011) Christian Weber et al.   NATURE MEDICINE

Hyperactive S6K1 Mediates Oxidative Stress and Endothelial Dysfunction in Aging: Inhibition by Resveratrol

(2011) Angana G. Rajapakse et al.   PLoS One

Caloric restriction improves coagulation and inflammation profile in obese mice

(2011) H. Roger Lijnen et al.   THROMBOSIS RESEARCH

Obesity, insulin resistance and free fatty acids

(2011) Guenther Boden   Current Opinion in Endocrinology Diabetes and Obesity

AMPK in cardiovascular health and disease

(2010) Najeeb A Shirwany et al.   ACTA PHARMACOLOGICA SINICA

Modulation of white adipose tissue proteome by aging and calorie restriction

(2010) Adamo Valle et al.   AGING CELL

Short-term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress

(2010) Catarina Rippe et al.   AGING CELL

Gender-specific effects of caloric restriction on the balance of vascular nitric oxide and superoxide radical

(2010) Shih-Hsuan Chou et al.   CARDIOVASCULAR RESEARCH

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

SIRT3 Deacetylates Mitochondrial 3-Hydroxy-3-Methylglutaryl CoA Synthase 2 and Regulates Ketone Body Production

(2010) Tadahiro Shimazu et al.   Cell Metabolism

SIRT1 Promotes Proliferation and Prevents Senescence Through Targeting LKB1 in Primary Porcine Aortic Endothelial Cells

(2010) Yi Zu et al.   CIRCULATION RESEARCH

Carotid Plaque Inflammation Is Associated With Cerebral Microembolism in Patients With Recent Transient Ischemic Attack or Stroke

(2010) Ramez Reda Moustafa et al.   Circulation-Cardiovascular Imaging

SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis

(2010) Sokrates Stein et al.   EUROPEAN HEART JOURNAL

Caloric restriction improves endothelial dysfunction during vascular aging: Effects on nitric oxide synthase isoforms and oxidative stress in rat aorta

(2010) Michela Zanetti et al.   EXPERIMENTAL GERONTOLOGY

Caloric restriction reverses high-fat diet-induced endothelial dysfunction and vascular superoxide production in C57Bl/6 mice

(2010) Juha Ketonen et al.   HEART AND VESSELS

Calorie Restriction Prevents Hypertension and Cardiac Hypertrophy in the Spontaneously Hypertensive Rat

(2010) Vernon W. Dolinsky et al.   HYPERTENSION

FoxO1 Mediates an Autofeedback Loop Regulating SIRT1 Expression

(2010) Shiqin Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage α1 AMP-activated Protein Kinase (α1AMPK) Antagonizes Fatty Acid-induced Inflammation through SIRT1

(2010) Zhenggang Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ethanol sensitizes mitochondria to the permeability transition by inhibiting deacetylation of cyclophilin-D mediated by sirtuin-3

(2010) Nataly Shulga et al.   JOURNAL OF CELL SCIENCE

Improved cardiac metabolism and activation of the RISK pathway contributes to improved post-ischemic recovery in calorie restricted mice

(2010) Miranda M. Y. Sung et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Life-long caloric restriction elicits pronounced protection of the aged myocardium: A role for AMPK

(2010) Andrew G. Edwards et al.   MECHANISMS OF AGEING AND DEVELOPMENT

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Pathophysiology and epidemiology of abdominal aortic aneurysms

(2010) Ian M. Nordon et al.   Nature Reviews Cardiology

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nitric oxide and oxidative stress in vascular disease

(2010) Ulrich Förstermann   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

(2010) Hiyaa Singhee Ghosh et al.   PLoS One

Shear stress, SIRT1, and vascular homeostasis

(2010) Z. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

(2009) R. J. Shaw   Acta Physiologica

Changes in lipid distribution during aging and its modulation by calorie restriction

(2009) Ji Young Kim et al.   AGE

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways inC. elegans

(2009) Eric L. Greer et al.   AGING CELL

Berberine suppresses proinflammatory responses through AMPK activation in macrophages

(2009) Hyun Woo Jeong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Protective Role of SIRT1 in Diabetic Vascular Dysfunction

(2009) Masayuki Orimo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

AMPKα1 regulates the antioxidant status of vascular endothelial cells

(2009) Sergio L. Colombo et al.   BIOCHEMICAL JOURNAL

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

(2009) Aparna Purushotham et al.   Cell Metabolism

Activation and Signaling by the AMP-Activated Protein Kinase in Endothelial Cells

(2009) Beate Fisslthaler et al.   CIRCULATION RESEARCH

AMP-Activated Protein Kinase Functionally Phosphorylates Endothelial Nitric Oxide Synthase Ser633

(2009) Zhen Chen et al.   CIRCULATION RESEARCH

SIRT1 Suppresses Activator Protein-1 Transcriptional Activity and Cyclooxygenase-2 Expression in Macrophages

(2009) Ran Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway

(2009) Vinodkumar B. Pillai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1

(2009) Anna Csiszar et al.   MECHANISMS OF AGEING AND DEVELOPMENT

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

SIRT1 Transcription Is Decreased in Visceral Adipose Tissue of Morbidly Obese Patients with Severe Hepatic Steatosis

(2009) Cíntia dos Santos Costa et al.   OBESITY SURGERY

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

Obesity Increases Vascular Senescence and Susceptibility to Ischemic Injury Through Chronic Activation of Akt and mTOR

(2009) C.-Y. Wang et al.   Science Signaling

Caloric restriction, SIRT1 and longevity

(2009) Carles Cantó et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Impact of 6-mo caloric restriction on myocardial ischemic tolerance: possible involvement of nitric oxide-dependent increase in nuclear Sirt1

(2008) Ken Shinmura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cilostazol Inhibits Oxidative Stress–Induced Premature Senescence Via Upregulation of Sirt1 in Human Endothelial Cells

(2008) Hidetaka Ota et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPK

(2008) Peter F. Mount et al.   ATHEROSCLEROSIS

Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals

(2008) Michael Lefevre et al.   ATHEROSCLEROSIS

Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice

(2008) Q.-j. Zhang et al.   CARDIOVASCULAR RESEARCH

Diet and Aging

(2008) Matthew D.W. Piper et al.   Cell Metabolism

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

(2008) Jérôme N. Feige et al.   Cell Metabolism

Suppression of the JNK Pathway by Induction of a Metabolic Stress Response Prevents Vascular Injury and Dysfunction

(2008) Eberhard Schulz et al.   CIRCULATION

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

(2008) Marcella Fulco et al.   DEVELOPMENTAL CELL

Low Sirt1 expression, which is upregulated by fasting, in human adipose tissue from obese women

(2008) S B Pedersen et al.   INTERNATIONAL JOURNAL OF OBESITY

Caloric Restriction Stimulates Revascularization in Response to Ischemia via Adiponectin-mediated Activation of Endothelial Nitric-oxide Synthase

(2008) Megumi Kondo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

(2008) Fan Lan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

(2008) Xiuyun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Nitric Oxide as an Endogenous Activator of the AMP-activated Protein Kinase in Vascular Endothelial Cells

(2008) Junhua Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics

SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice

(2008) Gino Boily et al.   PLoS One

The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth

(2008) Ron Firestein et al.   PLoS One

Prevention of atherosclerosis by the mTOR inhibitor everolimus in LDLR−/− mice despite severe hypercholesterolemia

(2007) Marc A. Mueller et al.   ATHEROSCLEROSIS