Article
Peripheral Vascular Disease
Dongling Luo, Wenxin Li, Changming Xie, Li Yin, Xiaoyan Su, Jie Chen, Hui Huang
Summary: The research found that capsaicin can reduce coronary artery calcification and inhibit osteogenic transdifferentiation in both in vivo and in vitro models. It does so by upregulating SIRT6, which promotes deacetylation and degradation of Hif1 alpha.
Review
Oncology
Qinghua Wu, Li You, Eugenie Nepovimova, Zbynek Heger, Wenda Wu, Kamil Kuca, Vojtech Adam
Summary: Hypoxia in the tumor microenvironment weakens cytotoxic T cell function and promotes recruitment of regulatory T cells, thereby reducing tumor immunogenicity. Hypoxia-inducible factors (HIFs), especially HIF1A and HIF2A, play important roles in tumor immune escape through various mechanisms. Understanding these mechanisms can lead to the development of targeted therapies for tumor treatment.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Hong Wang, Changli Zhang, Zhiyong Jiang, Li Xu, Zhipeng Liu
Summary: In this study, phenothiazine-fused boron complexes were identified as promising scaffolds for ratiometric fluorescent hypochlorite probes. The synthesized complexes demonstrated ultrafast and ratiometric absorption/fluorescence changes for hypochlorite. Additionally, an endoplasmic reticulum-targeting probe was developed and showed excellent real-time imaging ability for both endogenous and exogenous hypochlorite in living cells.
DALTON TRANSACTIONS
(2023)
Article
Nanoscience & Nanotechnology
Wen-Sheng Tzeng, Wei-Lin Teng, Pao-Hsien Huang, Tzu-Ching Lin, Feng-Lin Yen, Yow-Ling Shiue
Summary: The study demonstrated that the prepared PTS nanoparticles (PSN) showed better antihepatoma activities in HepG2 cells, especially under hypoxic conditions, and effectively improved the water solubility and drug release of PTS.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Spectroscopy
Xuemei Lin, Wenjing Liu, Shuangyang Xu, Zhanxian Li, Hongyan Zhang, Mingming Yu
Summary: Sulfur dioxide is an environmental pollutant easily absorbed by the human body, and abnormal levels of sulfite and bisulfite have been shown to be related to various diseases. Therefore, developing an effective method to detect bisulfite is necessary. This study designed and synthesized three HSO3- sensitive ratiometric fluorescent probes, which can image HSO3- in living cells, and showed good fluorescence stability and strong anti-interference ability.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Polymer Science
Shi-Lu Ji, Hua-Min Lan, Sen-Sen Zhou, Xiao-Ke Zhang, Wei-Zhi Chen, Xi-Qun Jiang
Summary: Two new ratiometric hypoxia probes (Ir-C343 and Ir-GFP) were synthesized by incorporating fluorescent internal standard molecules (coumarin 343 and green fluorescent protein) into a bis[1-(9,9-dimethyl-9H-fluoren-2-yl)-isoquinoline] succinylacetone Ir(III) (Ir-fliq). The probes exhibited a ratiometric response to oxygen concentration, as the fluorescence intensity of the internal standard remained constant while the Ir-fliq moiety remained sensitive to oxygen concentration. Ir-GFP showed promising potential in ratiometric hypoxia imaging due to its long excitation wavelength, water solubility, biocompatibility, and lower fluorescence intensity compared to Ir-fliq.
CHINESE JOURNAL OF POLYMER SCIENCE
(2023)
Article
Peripheral Vascular Disease
Hannah E. Morris, Karla B. Neves, Margaret Nilsen, Augusto C. Montezano, Margaret R. MacLean, Rhian M. Touyz
Summary: This study found that Notch3 plays an important role in vascular diseases, particularly pulmonary arterial hypertension. It was discovered that increased activation of Notch3 leads to oxidative and endoplasmic reticulum stress, which in turn triggers redox signaling associated with procontractile pulmonary artery state, pulmonary vascular dysfunction, and the development of pulmonary arterial hypertension.
Article
Chemistry, Analytical
Haihong Liu, Wenjuan Chen, Wei Yuan, Jian Gao, Qian Zhang, Peng Zhang, Caifeng Ding
Summary: In this study, a novel pH sensitive fluorescent probe, Hcy-OH, was developed for the detection and imaging of ROSs under different pH conditions. Hcy-OH exhibited specific response to different ROSs at varying pH values, showing selectivity for ONOO- under acidic condition, ClO- under neutral condition and 1O2 under alkaline condition. This sensing scheme was proven to be effective for imaging of inflamed tissue, indicating its potential for accurate monitoring of arthritis at an organism level. The elaborated receptor Hcy-OH could serve as a powerful tool to reveal the relationship between the physiology and pathology of inflammation.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Chao Wang, Xianhao Zhao, Kaiyu Wu, Shuyi Lv, Chunlei Zhu
Summary: Sensing temperature is crucial for understanding physiological and pathological processes. However, highly sensitive temperature sensing with organic fluorescent nanothermometers is challenging. In this study, a ratiometric fluorescent nanogel thermometer is developed to determine bactericidal temperature. The nanogel exhibits reversible spectral changes based on its hydrophilic-to-hydrophobic transition, and its emission intensity can be correlated to external temperature. The nanogel shows promise in predicting photothermal antibacterial effects and other temperature-related biological events.
Article
Oceanography
Liqin Duan, Jinming Song, Xuegang Li, Huamao Yuan
Summary: This study evaluates the migration and removal of redox sensitive elements (RSEs) at the sediment-water interface (SWI) off the Changjiang Estuary by examining the porewater and solid RSEs. The concentrations of porewater and solid RSEs decrease with depth, and the removal of Mo is mediated by Fe-S phase while the removal of U is microbial-mediated reduction. The peaks of dissolved nitrate, Fe2+ and acid volatile sulfur (AVS) correspond to the downward removal of V, U and Mo, and the upward shift of RSE peaks in porewater reflects the occurrence of hypoxia in summer.
CONTINENTAL SHELF RESEARCH
(2023)
Article
Medicine, Research & Experimental
Min Kyung Park, Jun Ji, Keeok Haam, Tae-Hee Han, Seona Lim, Mi-Jung Kang, Soon Sung Lim, Hyun Seung Ban
Summary: Licochalcone A, a component of Glycyrrhiza uralensis, demonstrates potential as a therapeutic agent in hypoxic cancer cells by inhibiting HIF-1 alpha accumulation and mitochondrial respiration, leading to increased oxygen content and suppression of cancer cell viability.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Mike Stembridge, Ryan L. Hoiland, Alexandra M. Williams, Connor A. Howe, Joseph Donnelly, Tony G. Dawkins, Aimee Drane, Michael M. Tymko, Christopher Gasho, James Anholm, Lydia L. Simpson, Jonathan P. Moore, Damian M. Bailey, David B. MacLeod, Philip N. Ainslie
Summary: The study demonstrates that hemodilution can impact hypoxic pulmonary vasoconstriction (HPV) through increased frictional force and vasoactive signaling from erythrocytes. The balance of these mechanisms is influenced by the duration of hypoxia exposure and hematocrit level. While hemodilution mildly increased pulmonary artery systolic pressure (PASP) and pulmonary vascular resistance (PVR) at sea level, it did not significantly alter these parameters at high altitude, where both remained sensitive to additional acute hypoxia. In Andean high-altitude natives with excessive erythrocytosis, hemodilution lowered PVR but did not change PASP due to compensatory increase in cardiac output.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Review
Chemistry, Inorganic & Nuclear
Li Huang, Shaojing Zhao, Jiasheng Wu, Le Yu, Nem Singh, Ke Yang, Minhuan Lan, Pengfei Wang, Jong Seung Kim
Summary: Photodynamic therapy (PDT) is a preferred clinical technology for treating tumors, but the hypoxic tumor microenvironment weakens its efficiency. Strategies for improving PDT efficacy in hypoxic tumors include increasing oxygen concentration, disregarding hypoxia, and exploiting hypoxia. Combining PDT with other therapeutics can also enhance treatment outcomes.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Analytical
Lingfei Li, Dan Lin, Shihao Xu, Liang Yang, Shaoming Yu, Changlong Jiang
Summary: A sensitive and rapid visual device has been developed for in-situ monitoring of trace antibiotic oxytetracycline. The device can rapidly display a significant color change upon adding oxytetracycline, and can detect it in a visible and dosage-sensitive manner. The practical applications in water, urine, and pork samples have demonstrated the feasibility and accuracy of this device.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Qin Tan, Xuanxuan An, Shuang Pan, Shujun Zhen, Yongmei Hu, Xiaoli Hu
Summary: A novel ratiometric fluorescent sensor for gallic acid was developed using carbon dots, CoOOH nanoflakes, and o-phenylenediamine, showing high sensitivity with a linear response range of 2.0-60.0 μmol L-1 and a detection limit of 1.2 μmol L-1. The sensor was successfully applied to detect gallic acid in green tea.
MICROCHEMICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Marc A. Sala, Cong Chen, Qiao Zhang, Hanh Chi Do-Umehara, Wenjiao Wu, Alexander V. Misharin, Gregory B. Waypa, Deyu Fang, G. R. Scott Budinger, Shuwen Liu, Navdeep S. Chandel, Paul T. Schumacker, Jacob I. Sznajder, Jing Liu
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Medicine, Research & Experimental
Jaime N. Guzman, Ema Ilijic, Ben Yang, Javier Sanchez-Padilla, David Wokosin, Dan Galtieri, Jyothisri Kondapalli, Paul T. Schumacker, D. James Surmeier
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Review
Neurosciences
Kimberly A. Smith, Paul T. Schumacker
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Cell Biology
Shuang Zhang, Samuel Weinberg, Matthew DeBerge, Anastasiia Gainullina, Matthew Schipma, Jason M. Kinchen, Issam Ben-Sahra, David R. Gius, Laurent Yvan-Charvet, Navdeep S. Chandel, Paul T. Schumacker, Edward B. Thorp
Article
Multidisciplinary Sciences
Samuel E. Weinberg, Benjamin D. Singer, Elizabeth M. Steinert, Carlos A. Martinez, Manan M. Mehta, Inmaculada Martinez-Reyes, Peng Gao, Kathryn A. Helmin, Hiam Abdala-Valencia, Laura A. Sena, Paul T. Schumacker, Laurence A. Turka, Navdeep S. Chandel
Editorial Material
Biochemistry & Molecular Biology
Paul T. Schumacker
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2019)
Article
Medicine, Research & Experimental
Daniel L. Galvan, Jianyin Long, Nathanael Green, Benny H. Chang, Jamie S. Lin, Paul Schumacker, Luan D. Truong, Paul Overbeek, Farhad R. Danesh
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Editorial Material
Respiratory System
Gregory B. Waypa, Paul T. Schumacker
EUROPEAN RESPIRATORY JOURNAL
(2019)
Correction
Neurosciences
Steven M. Graves, Zhong Xie, Kristen A. Stout, Enrico Zampese, Lena F. Burbulla, Jean C. Shih, Jyothisri Kondapalli, Tommaso Patriarchi, Lin Tian, Lars Brichta, Paul Greengard, Dimitri Krainc, Paul T. Schumacker, D. James Surmeier
NATURE NEUROSCIENCE
(2020)
Editorial Material
Critical Care Medicine
Sanjay H. Chotirmall, Fernando J. Martinez, Paul T. Schumacker, Colin R. Cooke, Nitin Seam, Laurent Brochard, Robert M. Tighe, Bruce D. Levy, Diane Gern, Jadwiga A. Wedzicha
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Medicine, General & Internal
Colleen Peyton, Christa Einspieler, Toril Fjortoft, Lars Adde, Michael D. Schreiber, Alexander Drobyshevsky, Jeremy D. Marks
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Kimberly A. Smith, Gregory B. Waypa, V. Joseph Dudley, G. R. Scott Budinger, Hiam Abdala-Valencia, Elizabeth Bartom, Paul T. Schumacker
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2020)
Editorial Material
Biochemistry & Molecular Biology
Paul T. Schumacker
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Simran S. Sabharwal, V. Joseph Dudley, Charlene Landwerlin, Paul T. Schumacker
Summary: Cancer cells experience increased levels of oxidant stress due to oncogene activation, nucleotide biosynthesis, and growth factor receptor signaling. Mitochondrial ROS contribute to this stress. Assessing the importance of mitochondrial ROS in cancer cells is difficult due to the effects of electron transport chain inhibitors. This study showed that mitochondrial H2O2 signaling contributes to tumor cell proliferation and survival through HIF-dependent and HIF-independent mechanisms.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Respiratory System
Daniel S. Goldberg, David J. Lederer, Ellen J. MacKenzie, Marc Moss, Jonathan M. Samet, Paul T. Schumacker, Jadwiga A. Wedzicha, Matthew K. Wynia
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2018)