Natural and semisynthetic protein tyrosine phosphatase 1B (PTP1B) inhibitors as anti-diabetic agents

The effects of C-glycosylation of luteolin on its antioxidant, anti-Alzheimer’s disease, anti-diabetic, and anti-inflammatory activities

(2014) Jae Sue Choi et al.   ARCHIVES OF PHARMACAL RESEARCH

Synthesis and evaluation of several oleanolic acid glycoconjugates as protein tyrosine phosphatase 1B inhibitors

(2014) Qingchao Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Sarsolenane and Capnosane Diterpenes from the Hainan Soft CoralSarcophyton trocheliophorumMarenzeller as PTP1B Inhibitors

(2014) Lin-Fu Liang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

New triterpenoids with protein tyrosine phosphatase 1B inhibition fromCedrela odorata

(2014) Wen-Bin Wu et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Highly Conjugated Norditerpenoid and Pyrroloquinoline Alkaloids with Potent PTP1B Inhibitory Activity from Nigella glandulifera

(2014) Qi-Bin Chen et al.   JOURNAL OF NATURAL PRODUCTS

New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne

(2014) Shu-Juan Piao et al.   Marine Drugs

Oleanane triterpenes as protein tyrosine phosphatase 1B (PTP1B) inhibitors from Camellia japonica

(2014) Mohammad Nasir Uddin et al.   PHYTOCHEMISTRY

Protein Tyrosine Phosphatase 1B Inhibitory Activity of Lavandulyl Flavonoids from Roots of Sophora flavescens

(2014) Tatsunori Sasaki et al.   PLANTA MEDICA

Three novel degraded steroids from cultures of the Basidiomycete Antrodiella albocinnamomea

(2014) Zi-Ming Chen et al.   STEROIDS

Novel grayanane diterpenoids from Rhododendron principis

(2014) Chang-Chang Liu et al.   TETRAHEDRON

Protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase inhibitory activities of Schisandra chinensis (Turcz.) Baill

(2014) Linlin Fang et al.   Journal of Functional Foods

Kinetics and molecular docking studies of pimarane-type diterpenes as protein tyrosine phosphatase (PTP1B) inhibitors from Aralia continentalis roots

(2013) Hyun Ah Jung et al.   ARCHIVES OF PHARMACAL RESEARCH

Potent α-glucosidase and protein tyrosine phosphatase 1B inhibitors from Artemisia capillaris

(2013) Md. Nurul Islam et al.   ARCHIVES OF PHARMACAL RESEARCH

Isomalabaricane triterpenes with potent protein-tyrosine phosphatase 1B (PTP1B) inhibition from the Hainan sponge Stelletta sp.

(2013) Duo-Qing Xue et al.   BIOCHEMICAL SYSTEMATICS AND ECOLOGY

Cembrane diterpenoids from the soft coral Sarcophyton trocheliophorum Marenzeller as a new class of PTP1B inhibitors

(2013) Lin-Fu Liang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Euryspongins A–C, three new unique sesquiterpenes from a marine sponge Euryspongia sp.

(2013) Hiroyuki Yamazaki et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors

(2013) Wei Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pharmacological Inhibition of Protein Tyrosine Phosphatase 1B: A Promising Strategy for the Treatment of Obesity and Type 2 Diabetes Mellitus

(2013) E. Panzhinskiy et al.   CURRENT MEDICINAL CHEMISTRY

Discovery of novel bromophenol 3,4-dibromo-5-(2-bromo-3,4-dihydroxy-6-(isobutoxymethyl)benzyl)benzene-1,2-diol as protein tyrosine phosphatase 1B inhibitor and its anti-diabetic properties in C57BL/KsJ-db/db mice

(2013) Bo Jiang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of oleanolic acid derivatives as PTP1B inhibitors

(2013) Qing-Chao Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Geranylated 2-arylbenzofurans from Morus alba var. tatarica and their α-glucosidase and protein tyrosine phosphatase 1B inhibitory activities

(2013) Ya-Long Zhang et al.   FITOTERAPIA

Bioactive Properties of the Main Triterpenes Found in Olives, Virgin Olive Oil, and Leaves of Olea europaea

(2013) Cristina Sánchez-Quesada et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

HPN, a Synthetic Analogue of Bromophenol from Red Alga Rhodomela confervoides: Synthesis and Anti-Diabetic Effects in C57BL/KsJ-db/db Mice

(2013) Dayong Shi et al.   Marine Drugs

PTP1B Inhibitory and Anti-Inflammatory Effects of Secondary Metabolites Isolated from the Marine-Derived Fungus Penicillium sp. JF-55

(2013) Dong-Sung Lee et al.   Marine Drugs

Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades

(2012) Cheng-shi Jiang et al.   ACTA PHARMACOLOGICA SINICA

Design, Synthesis, and Biological Evaluation of Bromophenol Derivatives as Protein Tyrosine Phosphatase 1B Inhibitors

(2012) Bo Jiang et al.   ARCHIV DER PHARMAZIE

Inhibitory activity of Aralia continentalis roots on protein tyrosine phosphatase 1B and rat lens aldose reductase

(2012) Hee Jin Jung et al.   ARCHIVES OF PHARMACAL RESEARCH

New prenylated isoflavonoids as protein tyrosine phosphatase 1B (PTP1B) inhibitors from Erythrina addisoniae

(2012) Phi Hung Nguyen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Bromophenols as inhibitors of protein tyrosine phosphatase 1B with antidiabetic properties

(2012) Dayong Shi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don

(2012) Yeon Ho Choi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B

(2012) Hai-Bing He et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Skeletal Muscle Protein Tyrosine Phosphatase 1B Regulates Insulin Sensitivity in African Americans

(2012) A. J. Stull et al.   DIABETES

Design, synthesis, and molecular hybrids of caudatin and cinnamic acids as novel anti-hepatitis B virus agents

(2012) Li-Jun Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

PTP1B and TCPTP - nonredundant phosphatases in insulin signaling and glucose homeostasis

(2012) Tony Tiganis   FEBS Journal

Promising antidiabetic potential of fucoxanthin isolated from the edible brown algae Eisenia bicyclis and Undaria pinnatifida

(2012) Hyun Ah Jung et al.   FISHERIES SCIENCE

A polybromodiphenyl ether from an Indonesian marine sponge Lamellodysidea herbacea and its chemical derivatives inhibit protein tyrosine phosphatase 1B, an important target for diabetes treatment

(2012) Hiroyuki Yamazaki et al.   Journal of Natural Medicines

Protein Tyrosine Phosphatase 1B and α-Glucosidase Inhibitory Phlorotannins from Edible Brown Algae,Ecklonia stoloniferaandEisenia bicyclis

(2011) Hye Eun MOON et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Synthesis of three bromophenols from red algae as PTP1B inhibitors

(2011) Shuju Guo et al.   CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY

Synthesis and protein tyrosine phosphatase 1B inhibition activities of two new synthetic bromophenols and their methoxy derivatives

(2011) Yongchao Cui et al.   CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY

Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP–1B: In vitro, in silico, and in vivo approaches

(2011) Juan José Ramírez-Espinosa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Management of type 2 diabetes: new and future developments in treatment

(2011) Abd A Tahrani et al.   LANCET

Bromophenols in Marine Algae and Their Bioactivities

(2011) Ming Liu et al.   Marine Drugs

Dysidavarones A–D, New Sesquiterpene Quinones from the Marine Sponge Dysidea avara

(2011) Wei-Hua Jiao et al.   ORGANIC LETTERS

Structural and stereochemical studies of five new pregnane steroids from the stem bark of Toona ciliata var. pubescens

(2011) Jian-Rong Wang et al.   STEROIDS

Berberine inhibits PTP1B activity and mimics insulin action

(2010) Chunhua Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dammaranes from Gynostemma pentaphyllum and synthesis of their derivatives as inhibitors of protein tyrosine phosphatase 1B

(2010) Ji-Qing Xu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Highly brominated metabolites from marine red alga Laurencia similis inhibit protein tyrosine phosphatase 1B

(2010) Jianchun Qin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Association between childhood obesity and subsequent Type 1 diabetes: a systematic review and meta-analysis

(2010) K. C. Verbeeten et al.   DIABETIC MEDICINE

Synthesis and Biological Evaluation of Oleanolic Acid Derivatives As Inhibitors of Protein Tyrosine Phosphatase 1B

(2010) Shan Qian et al.   JOURNAL OF NATURAL PRODUCTS

Bioactivity-Guided Isolation of 1,2,3,4,6-Penta-O-galloyl-d-glucopyranose fromPaeonia lactifloraRoots As a PTP1B Inhibitor

(2010) Renate R. Baumgartner et al.   JOURNAL OF NATURAL PRODUCTS

Protein Tyrosine Phosphatase 1B Inhibitors: A Molecular Level Legitimate Approach for the Management of Diabetes Mellitus

(2010) Suresh Thareja et al.   MEDICINAL RESEARCH REVIEWS

Inhibition of PTP1B by Trodusquemine (MSI-1436) Causes Fat-specific Weight Loss in Diet-induced Obese Mice

(2010) Kristen A. Lantz et al.   Obesity

Psidials A−C, Three Unusual Meroterpenoids from the Leaves ofPsidium guajavaL

(2010) Hui-Zheng Fu et al.   ORGANIC LETTERS

Protein tyrosine phosphatase 1B inhibitory activity of 24-norursane triterpenes isolated from Weigela subsessilis

(2010) MinKyun Na et al.   PHYTOTHERAPY RESEARCH

A sesquiterpene quinone, dysidine, from the sponge Dysidea villosa, activates the insulin pathway through inhibition of PTPases

(2009) Yu Zhang et al.   ACTA PHARMACOLOGICA SINICA

Docking Simulations and in Vitro Assay Unveil Potent Inhibitory Action of Papaverine against Protein Tyrosine Phosphatase 1B

(2009) Yasser Bustanji et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis

(2009) Duc Manh Hoang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060

(2009) Changon Seo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Protein tyrosine phosphatase 1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic lichen Stereocaulon alpinum

(2009) Changon Seo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B

(2009) Wen-Wei Qiu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Impact of Natural Products on Developing New Anti-Cancer Agents†

(2009) Gordon M. Cragg et al.   CHEMICAL REVIEWS

Phenolic compounds from the leaves of Cyclocarya paliurus (Batal.) Ijinskaja and their inhibitory activity against PTP1B

(2009) Juan Zhang et al.   FOOD CHEMISTRY

New Eremophilane Sesquiterpenes from the Roots ofLigularia fischeri

(2009) Meicai Deng et al.   HELVETICA CHIMICA ACTA

Protein tyrosine phosphatase 1B inhibitory by dammaranes from Vietnamese Giao-Co-Lam tea

(2009) Tran Manh Hung et al.   JOURNAL OF ETHNOPHARMACOLOGY

Recent Advances in the Discovery of Competitive Protein Tyrosine Phosphatase 1B Inhibitors for the Treatment of Diabetes, Obesity, and Cancer

(2009) Andrew P. Combs   JOURNAL OF MEDICINAL CHEMISTRY

Isolation of Betulinic Acid, its Methyl Ester and Guaiane Sesquiterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Roots of Saussurea lappa C.B.Clarke

(2009) Ji Choi et al.   MOLECULES

Pterocarpans with inhibitory effects on protein tyrosine phosphatase 1B from Erythrina lysistemon Hutch.

(2009) Trong Tuan Dao et al.   PHYTOCHEMISTRY

A novel sesquiterpene quinone from Hainan sponge Dysidea villosa

(2008) Yan Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Total synthesis of bis-(2,3-dibromo-4,5-dihydroxyphenyl)-methane as potent PTP1B inhibitor

(2008) Jing Li et al.   CHINESE CHEMICAL LETTERS

Hierarchical recognition on the taxonomy of Nitzschia closterium f. minutissima

(2008) Juan Shi et al.   CHINESE SCIENCE BULLETIN

Recent and emerging anti-diabetes targets

(2008) Michael L. Mohler et al.   MEDICINAL RESEARCH REVIEWS