VKORC1 and VKORC1L1: Why do Vertebrates Have Two Vitamin K 2,3-Epoxide Reductases?

Tris(3-hydroxypropyl)phosphine is superior to dithiothreitol for in vitro assessment of vitamin K 2,3-epoxide reductase activity

(2015) Christoph Krettler et al.   ANALYTICAL BIOCHEMISTRY

Zebrafish vitamin K epoxide reductases: expression in vivo, along extracellular matrix mineralization and under phylloquinone and warfarin in vitro exposure

(2015) Ignacio Fernández et al.   FISH PHYSIOLOGY AND BIOCHEMISTRY

GGCX and VKORC1 inhibit osteocalcin endocrine functions

(2015) Mathieu Ferron et al.   JOURNAL OF CELL BIOLOGY

A new heart for a new head in vertebrate cardiopharyngeal evolution

(2015) Rui Diogo et al.   NATURE

Scenarios for the making of vertebrates

(2015) Nicholas D. Holland et al.   NATURE

The origin and early phylogenetic history of jawed vertebrates

(2015) Martin D. Brazeau et al.   NATURE

Evidence of a target resistance to antivitamin K rodenticides in the roof ratRattus rattus: identification and characterisation of a novel Y25F mutation in theVkorc1gene

(2015) Joffrey Goulois et al.   PEST MANAGEMENT SCIENCE

The human transcriptome across tissues and individuals

(2015) M. Mele et al.   SCIENCE

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

Two enzymes catalyze vitamin K 2,3-epoxide reductase activity in mouse: VKORC1 is highly expressed in exocrine tissues while VKORC1L1 is highly expressed in brain

(2015) Michael Caspers et al.   THROMBOSIS RESEARCH

Phylogeny of the Vitamin K 2,3-Epoxide Reductase (VKOR) Family and Evolutionary Relationship to the Disulfide Bond Formation Protein B (DsbB) Family

(2015) Carville Bevans et al.   Nutrients

Biological Databases for Human Research

(2015) Dong Zou et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Matrix Gla protein and osteocalcin: From gene duplication to neofunctionalization

(2014) M. Leonor Cancela et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Identification and characterization of SlVKOR, a disulfide bond formation protein from Solanum lycopersicum, and bioinformatic analysis of plant VKORs

(2014) Chun-Mei Wan et al.   BIOCHEMISTRY-MOSCOW

Corrigendum to “Determination of the warfarin inhibition constant Ki for vitamin K 2,3-epoxide reductase complex subunit-1 (VKORC1) using an in vitro DTT-driven assay” [BBAGEN (2013) 4202–4210]

(2014) Carville G. Bevans et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Arg98Trp mutation in human VKORC1 causing VKCFD2 disrupts a di-arginine-based ER retention motif

(2014) K. J. Czogalla et al.   BLOOD

Identification of VKORC1 genotype leading to resistance to tecarfarin

(2014) Benjamin Matagrin et al.   JOURNAL OF CLINICAL PHARMACOLOGY

The realm of vitamin K dependent proteins: Shifting from coagulation toward calcification

(2014) Brecht A. G. Willems et al.   MOLECULAR NUTRITION & FOOD RESEARCH

A draft map of the human proteome

(2014) Min-Sik Kim et al.   NATURE

Mass-spectrometry-based draft of the human proteome

(2014) Mathias Wilhelm et al.   NATURE

Determination of the warfarin inhibition constant Ki for vitamin K 2,3-epoxide reductase complex subunit-1 (VKORC1) using an in vitro DTT-driven assay

(2013) Carville G. Bevans et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Human VKORC1 mutations cause variable degrees of 4-hydroxycoumarin resistance and affect putative warfarin binding interfaces

(2013) K. J. Czogalla et al.   BLOOD

A cellular system for quantitation of vitamin K cycle activity: structure-activity effects on vitamin K antagonism by warfarin metabolites

(2013) J. A. Haque et al.   BLOOD

UBIAD1-mediated vitamin K2 synthesis is required for vascular endothelial cell survival and development

(2013) J. M. Hegarty et al.   DEVELOPMENT

Comparative genetics of warfarin resistance

(2013) C. R. Müller et al.   Hamostaseologie

VKORC1L1, an Enzyme Rescuing the Vitamin K 2,3-Epoxide Reductase Activity in Some Extrahepatic Tissues during Anticoagulation Therapy

(2013) Abdessalem Hammed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new cell culture-based assay quantifies vitamin K 2,3-epoxide reductase complex subunit 1 function and reveals warfarin resistance phenotypes not shown by the dithiothreitol-driven VKOR assay

(2013) A. Fregin et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Evaluation of warfarin resistance using transcription activator-like effector nucleases-mediated vitamin K epoxide reductase knockout HEK293 cells

(2013) J.-K. Tie et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Development of an In Vitro Cell System from Zebrafish Suitable to Study Bone Cell Differentiation and Extracellular Matrix Mineralization

(2013) Parameswaran Vijayakumar et al.   Zebrafish

New insights into the catalytic mechanism of vitamin K epoxide reductase (VKORC1) - The catalytic properties of the major mutations of rVKORC1 explain the biological cost associated to mutations

(2013) Benjamin Matagrin et al.   FEBS Open Bio

The proteomic future: where mass spectrometry should be taking us

(2012) Jay J. Thelen et al.   BIOCHEMICAL JOURNAL

MotEvo: integrated Bayesian probabilistic methods for inferring regulatory sites and motifs on multiple alignments of DNA sequences

(2012) Phil Arnold et al.   BIOINFORMATICS

Vascular calcification: The price to pay for anticoagulation therapy with vitamin K-antagonists

(2012) Martijn L.L. Chatrou et al.   BLOOD REVIEWS

A gene expression atlas of the domestic pig

(2012) Tom C Freeman et al.   BMC BIOLOGY

VKORC1mutations detected in patients resistant to vitamin K antagonists are not all associated with a resistant VKOR activity

(2012) A. HODROGE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Vitamin K epoxide reductase contributes to protein disulfide formation and redox homeostasis within the endoplasmic reticulum

(2012) Lori A. Rutkevich et al.   MOLECULAR BIOLOGY OF THE CELL

An Endogenous Vitamin K-Dependent Mechanism Regulates Cell Proliferation in the Brain Subventricular Stem Cell Niche

(2012) Aurore Gely-Pernot et al.   STEM CELLS

Vitamin K and the Nervous System: An Overview of its Actions

(2012) Guylaine Ferland   Advances in Nutrition

Gla-Rich Protein, a New Player in Tissue Calcification?

(2012) M. Leonor Cancela et al.   Advances in Nutrition

Vitamin K-Dependent Carboxylation of Osteocalcin: Friend or Foe?

(2012) Caren M. Gundberg et al.   Advances in Nutrition

The Role of Vitamin K in Soft-Tissue Calcification

(2012) Elke Theuwissen et al.   Advances in Nutrition

Growth Arrest-Specific Gene 6 (gas6) and Vascular Hemostasis

(2012) Sandrine Laurance et al.   Advances in Nutrition

Vitamin K Status and Vascular Calcification: Evidence from Observational and Clinical Studies

(2012) M. Kyla Shea et al.   Advances in Nutrition

Mycobacterium tuberculosis Vitamin K Epoxide Reductase Homologue Supports Vitamin K–Dependent Carboxylation in Mammalian Cells

(2011) Jian-Ke Tie et al.   ANTIOXIDANTS & REDOX SIGNALING

Biochemical characterization of spontaneous mutants of rat VKORC1 involved in the resistance to antivitamin K anticoagulants

(2011) Ahmed Hodroge et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Endocrine Regulation of Male Fertility by the Skeleton

(2011) Franck Oury et al.   CELL

Role of vitamin K-dependent proteins in the arterial vessel wall

(2011) M. L. L. Chatrou et al.   Hamostaseologie

Human Vitamin K 2,3-Epoxide Reductase Complex Subunit 1-like 1 (VKORC1L1) Mediates Vitamin K-dependent Intracellular Antioxidant Function

(2011) Philipp Westhofen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

(2011) Graciana Diez-Roux et al.   PLOS BIOLOGY

How Proteins Form Disulfide Bonds

(2010) Matthieu Depuydt et al.   ANTIOXIDANTS & REDOX SIGNALING

Spatial and temporal regulation of gene expression in the mammalian growth plate

(2010) Julian C.K. Lui et al.   BONE

An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man

(2010) Timothy Ravasi et al.   CELL

Novel Insight into the Mechanism of the Vitamin K Oxidoreductase (VKOR)

(2010) Mark A. Rishavy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Growth-inhibiting conditions slow growth plate senescence

(2010) P. Forcinito et al.   JOURNAL OF ENDOCRINOLOGY

Coagulation in Vertebrates with a Focus on Evolution and Inflammation

(2010) Russell F. Doolittle   Journal of Innate Immunity

Thirteen novel VKORC1 mutations associated with oral anticoagulant resistance: insights into improved patient diagnosis and treatment

(2010) M. WATZKA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structure of a bacterial homologue of vitamin K epoxide reductase

(2010) Weikai Li et al.   NATURE

The Vitamin K-dependent Proteins: An Update

(2010) Guylaine Ferland   NUTRITION REVIEWS

A bimodular oxidoreductase mediates the specific reduction of phylloquinone (vitamin K1) in chloroplasts

(2010) Fabienne Furt et al.   PLANT JOURNAL

Expression Profiling of a Genetic Animal Model of Depression Reveals Novel Molecular Pathways Underlying Depressive-Like Behaviours

(2010) Ekaterini Blaveri et al.   PLoS One

Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners

(2010) S. Schulman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel mutations in the VKORC1 gene of wild rats and mice - a response to 50 years of selection pressure by warfarin?

(2009) Simone Rost et al.   BMC GENETICS

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

(2009) Harukazu Suzuki et al.   NATURE GENETICS

VKORC1 deficiency in mice causes early postnatal lethality due to severe bleeding

(2009) Gabriele Spohn et al.   THROMBOSIS AND HAEMOSTASIS

BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources

(2009) Chunlei Wu et al.   GENOME BIOLOGY

Vitamin K status is associated with childhood bone mineral content

(2008) Marieke J. H. van Summeren et al.   BRITISH JOURNAL OF NUTRITION

Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice

(2008) Mathieu Ferron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial species exhibit diversity in their mechanisms and capacity for protein disulfide bond formation

(2008) R. J. Dutton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA