VKORC1mutations detected in patients resistant to vitamin K antagonists are not all associated with a resistant VKOR activity

Biochemical characterization of spontaneous mutants of rat VKORC1 involved in the resistance to antivitamin K anticoagulants

(2011) Ahmed Hodroge et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

More on: endoplasmic reticulum loop VKORC1 substitutions cause warfarin resistance but do not diminish gamma-carboxylation of the vitamin K-dependent coagulation factors

(2011) D. J. HARRINGTON et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Novel Insight into the Mechanism of the Vitamin K Oxidoreductase (VKOR)

(2010) Mark A. Rishavy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thirteen novel VKORC1 mutations associated with oral anticoagulant resistance: insights into improved patient diagnosis and treatment

(2010) M. WATZKA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structure of a bacterial homologue of vitamin K epoxide reductase

(2010) Weikai Li et al.   NATURE

A newVKORC1mutation leading to an isolated resistance to fluindione

(2009) Katell Peoc’h et al.   BRITISH JOURNAL OF HAEMATOLOGY

VKORC1mutations in patients with partial resistance to phenprocoumon

(2009) Peter C. J. Schmeits et al.   BRITISH JOURNAL OF HAEMATOLOGY

Consequences of the Y139F Vkorc1 mutation on resistance to AVKs: in-vivo investigation in a 7th generation of congenic Y139F strain of rats

(2009) Agnes Grandemange et al.   Pharmacogenetics and Genomics

Genotype-guided dosing of coumarin derivatives: the European pharmacogenetics of anticoagulant therapy (EU-PACT) trial design

(2009) Rianne MF van Schie et al.   PHARMACOGENOMICS

A new VKORC1 allelic variant (p.Trp59Arg) in a patient with partial resistance to acenocoumarol and phenprocoumon

(2008) E. B. WILMS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Pharmacodynamic resistance to warfarin is associated with nucleotide substitutions inVKORC1

(2008) D. J. HARRINGTON et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Multiple genetic alterations in vitamin K epoxide reductase complex subunit 1 gene (VKORC1) can explain the high dose requirement during oral anticoagulation in humans

(2008) L. BODIN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS