Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M

Glucocorticoid sensitivity in health and disease

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The five Rs of glucocorticoid action during inflammation: ready, reinforce, repress, resolve, and restore

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Glucocorticoid receptor signaling in health and disease

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Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD

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Interleukin 1 Receptor–Associated Kinase M Impairs Host Defense During Pneumococcal Pneumonia

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Chronic obstructive pulmonary disease

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Insights into Negative Regulation by the Glucocorticoid Receptor from Genome-wide Profiling of Inflammatory Cistromes

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Disease Tolerance as a Defense Strategy

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Dissecting negative regulation of Toll-like receptor signaling

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CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt

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An Official American Thoracic Society Workshop Report: Features and Measurements of Experimental Acute Lung Injury in Animals

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Widespread Negative Response Elements Mediate Direct Repression by Agonist- Liganded Glucocorticoid Receptor

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Coactivation of GR and NFKB alters the repertoire of their binding sites and target genes

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DAP12 Promotes IRAK-M Expression and IL-10 Production by Liver Myeloid Dendritic Cells and Restrains Their T Cell Allostimulatory Ability

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TGF-β-induced IRAK-M expression in tumor-associated macrophages regulates lung tumor growth

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Maps and legends: The quest for dissociated ligands of the glucocorticoid receptor

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IL-1 receptor-associated kinase M downregulates DSS-induced colitis†

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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

(2010) Cory M. Johannessen et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

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Genome-wide transcriptional profiling of mononuclear phagocytes recruited to mouse lungs in response to alveolar challenge with the TLR2 agonist Pam3CSK4

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Involvement of interleukin-1 receptor-associated kinase (IRAK)-M in toll-like receptor (TLR) 7-mediated tolerance in RAW 264.7 macrophage-like cells

(2009) Ferdaus Hassan et al.   CELLULAR IMMUNOLOGY

Crosstalk in Inflammation: The Interplay of Glucocorticoid Receptor-Based Mechanisms and Kinases and Phosphatases

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Abrogation of Glucocorticoid Receptor Dimerization Correlates with Dissociated Glucocorticoid Behavior of Compound A

(2009) Steven Robertson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adiponectin Promotes Endotoxin Tolerance in Macrophages by Inducing IRAK-M Expression

(2009) Vassiliki Zacharioudaki et al.   JOURNAL OF IMMUNOLOGY

Critical Role of IL-1 Receptor-Associated Kinase-M in Regulating Chemokine-Dependent Deleterious Inflammation in Murine Influenza Pneumonia

(2009) M. Seki et al.   JOURNAL OF IMMUNOLOGY

TREM-1 Activation Alters the Dynamics of Pulmonary IRAK-M Expression In Vivo and Improves Host Defense during Pneumococcal Pneumonia

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Identification of Potential Pathway Mediation Targets in Toll-like Receptor Signaling

(2009) Fan Li et al.   PLoS Computational Biology

Infection in the Pathogenesis and Course of Chronic Obstructive Pulmonary Disease

(2008) Sanjay Sethi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

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