NMR paves the way for atomic level descriptions of sparsely populated, transiently formed biomolecular conformers

Probing Slow Chemical Exchange at Carbonyl Sites in Proteins by Chemical Exchange Saturation Transfer NMR Spectroscopy

(2013) Pramodh Vallurupalli et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Localized Structural Fluctuations Promote Amyloidogenic Conformations in Transthyretin

(2013) Kwang Hun Lim et al.   JOURNAL OF MOLECULAR BIOLOGY

Allosteric inhibition through suppression of transient conformational states

(2013) Shiou-Ru Tzeng et al.   Nature Chemical Biology

Atomic-level description of ubiquitin folding

(2013) S. Piana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exceeding the limit of dynamics studies on biomolecules using high spin-lock field strengths with a cryogenically cooled probehead

(2012) David Ban et al.   JOURNAL OF MAGNETIC RESONANCE

Substrate-Dependent Millisecond Domain Motions in DNA Polymerase β

(2012) Rebecca B. Berlow et al.   JOURNAL OF MOLECULAR BIOLOGY

Site-Resolved Measurement of Microsecond-to-Millisecond Conformational-Exchange Processes in Proteins by Solid-State NMR Spectroscopy

(2012) Martin Tollinger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Studying “Invisible” Excited Protein States in Slow Exchange with a Major State Conformation

(2012) Pramodh Vallurupalli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transiently populated intermediate functions as a branching point of the FF domain folding pathway

(2012) D. M. Korzhnev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of an Intermediate State in Protein Folding and Aggregation

(2012) P. Neudecker et al.   SCIENCE

The Protein-Folding Problem, 50 Years On

(2012) K. A. Dill et al.   SCIENCE

Cross-Validation of the Structure of a Transiently Formed and Low Populated FF Domain Folding Intermediate Determined by Relaxation Dispersion NMR and CS-Rosetta

(2011) Julia Barette et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Nonnative Interactions in the FF Domain Folding Pathway from an Atomic Resolution Structure of a Sparsely Populated Intermediate: An NMR Relaxation Dispersion Study

(2011) Dmitry M. Korzhnev et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transient, Sparsely Populated Compact States of Apo and Calcium-Loaded Calmodulin Probed by Paramagnetic Relaxation Enhancement: Interplay of Conformational Selection and Induced Fit

(2011) Nicholas J. Anthis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Microsecond Time-Scale Conformational Exchange in Proteins: Using Long Molecular Dynamics Trajectory To Simulate NMR Relaxation Dispersion Data

(2011) Yi Xue et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical exchange saturation transfer (CEST): What is in a name and what isn't?

(2011) Peter C. M. van Zijl et al.   MAGNETIC RESONANCE IN MEDICINE

Solution structure of a minor and transiently formed state of a T4 lysozyme mutant

(2011) Guillaume Bouvignies et al.   NATURE

Transient Hoogsteen base pairs in canonical duplex DNA

(2011) Evgenia N. Nikolova et al.   NATURE

Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR

(2011) Nicolas L. Fawzi et al.   NATURE

Accessing protein conformational ensembles using room-temperature X-ray crystallography

(2011) J. S. Fraser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Dynamic Knockout Reveals That Conformational Fluctuations Influence the Chemical Step of Enzyme Catalysis

(2011) G. Bhabha et al.   SCIENCE

How Fast-Folding Proteins Fold

(2011) K. Lindorff-Larsen et al.   SCIENCE

Time-resolved structural studies of protein reaction dynamics: a smorgasbord of X-ray approaches

(2010) Sebastian Westenhoff et al.   ACTA CRYSTALLOGRAPHICA SECTION A

Origins of Specificity in Protein-DNA Recognition

(2010) Remo Rohs et al.   Annual Review of Biochemistry

Characterization of a Transient Unfolding Intermediate in a Core Mutant of γS-Crystallin

(2010) Bryon Mahler et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal structure of HIV-1 Tat complexed with human P-TEFb

(2010) Tahir H. Tahirov et al.   NATURE

Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs

(2010) Malka Kitayner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Millisecond timescale fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands

(2010) D. D. Boehr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploring sparsely populated states of macromolecules by diamagnetic and paramagnetic NMR relaxation

(2010) G. Marius Clore   PROTEIN SCIENCE

Atomic-Level Characterization of the Structural Dynamics of Proteins

(2010) D. E. Shaw et al.   SCIENCE

A Transient and Low-Populated Protein-Folding Intermediate at Atomic Resolution

(2010) Dmitry M. Korzhnev et al.   SCIENCE

Using NMR Chemical Shifts as Structural Restraints in Molecular Dynamics Simulations of Proteins

(2010) Paul Robustelli et al.   STRUCTURE

Long-timescale molecular dynamics simulations of protein structure and function

(2009) John L Klepeis et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Extending the Range of Microsecond-to-Millisecond Chemical Exchange Detected in Labeled and Unlabeled Nucleic Acids by Selective Carbon R1ρNMR Spectroscopy

(2009) Alexandar L. Hansen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Detection of a Transient Intermediate in a Rapid Protein Folding Process by Solid-State Nuclear Magnetic Resonance

(2009) Kan-Nian Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hidden alternative structures of proline isomerase essential for catalysis

(2009) James S. Fraser et al.   NATURE

Physicochemical principles that regulate the competition between functional and dysfunctional association of proteins

(2009) S. Pechmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Dynamism and Evolvability

(2009) N. Tokuriki et al.   SCIENCE

Characterization of Enzyme Motions by Solution NMR Relaxation Dispersion

(2008) J. Patrick Loria et al.   ACCOUNTS OF CHEMICAL RESEARCH

Using relaxation dispersion NMR spectroscopy to determine structures of excited, invisible protein states

(2008) D. Flemming Hansen et al.   JOURNAL OF BIOMOLECULAR NMR

The MC-Fold and MC-Sym pipeline infers RNA structure from sequence data

(2008) Marc Parisien et al.   NATURE

Estimation of the available free energy in a LOV2-Jα photoswitch

(2008) Xiaolan Yao et al.   Nature Chemical Biology

Amyloid formation by globular proteins under native conditions

(2008) Fabrizio Chiti et al.   Nature Chemical Biology

CS23D: a web server for rapid protein structure generation using NMR chemical shifts and sequence data

(2008) D. S. Wishart et al.   NUCLEIC ACIDS RESEARCH

Consistent blind protein structure generation from NMR chemical shift data

(2008) Y. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA