Article
Immunology
Kayla R. Wilson, Devi Jenika, Annabelle B. Blum, Christophe Macri, Bangyan Xu, Haiyin Liu, Patrick Schriek, Dominik Schienstock, Lauren Francis, F. Victor Makota, Satoshi Ishido, Scott N. Mueller, Mireille H. Lahoud, Irina Caminschi, Laura E. Edgington-Mitchell, Jose A. Villadangos, Justine D. Mintern
Summary: Ubiquitination of MHC II in dendritic cells affects the homeostasis, phenotype, cytokine production, and antigen proteolysis by DCs, with consequences for antigen presentation, T cell responses, and antibody-mediated immunity.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Hei Jung Kim, Joanna Bandola-Simon, Satoshi Ishido, Nathan W. Wong, Vishal N. Koparde, Maggie Cam, Paul A. Roche
Summary: Ubiquitination plays a crucial role in regulating MHC-II turnover on dendritic cells, impacting their ability to activate CD4 T cells and secrete IL-12. While MHC-II ubiquitination mutants exhibit functional defects, these can be reversed by activating DCs with LPS.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Haiyin Liu, Kayla R. Wilson, Ashley M. Firth, Christophe Macri, Patrick Schriek, Annabelle B. Blum, Javiera Villar, Samuel Wormald, Mitch Shambrook, Bangyan Xu, Hui Jing Lim, Hamish E. G. McWilliam, Andrew F. Hill, Laura E. Edgington-Mitchell, Irina Caminschi, Mireille H. Lahoud, Elodie Segura, Marco J. Herold, Jose A. Villadangos, Justine D. Mintern
Summary: This study reveals the critical role of ubiquitin-like protein 3 (UBL3) in the trafficking process controlled by MARCH1. UBL3 has wide-ranging immunological consequences and is essential for immune responses.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Chandran Sivasankar, Chamith Hewawaduge, John Hwa Lee
Summary: The latest omicron variants have mutations in the RBD that result in immune evasion and resistance to current vaccines. These variants pose a threat to vaccine effectiveness as most vaccines target the spike protein. Additionally, the dominant Th1 response induced by current vaccines needs to be addressed. Therefore, a vaccine that targets multiple SARS-CoV-2 proteins and provides broad-spectrum protection, as well as a balanced Th1 and Th2 response, is crucial in combating the pandemic.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Oncology
Simone Stupia, Christina Heeke, Alicia Bruggemann, Anne Zaremba, Beatrice Thier, Julia Kretz, Antje Sucker, Manuel Philip, Gennadiy Zelinskyy, Soldano Ferrone, Alexander Roesch, Susanne Horn, Eva Hadaschik, Dirk Schadendorf, Mirko Trilling, Ulf Dittmer, Klaus Griewank, Fang Zhao, Annette Paschen
Summary: Recent studies have shown that cytotoxic CD4 T cells can kill melanoma cells dependent on HLA class II (HLA-II). This study investigates the evolution of HLA-II-loss tumors that evade cytotoxic CD4 T cell activity and contribute to immunotherapy resistance. The findings highlight the importance of tumor cell-intrinsic HLA-II antigen presentation in disease control and suggest the need to overcome its down-regulation for better patient outcomes.
CLINICAL CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Binkai Chi, Muhammet M. Oeztuerk, Christina L. Paraggio, Claudia E. Leonard, Maria E. Sanita, Mahtab Dastpak, Jeremy D. O'Connell, Jordan A. Coady, Jiuchun Zhang, Steven P. Gygi, Rodrigo Lopez-Gonzalez, Shanye Yin, Robin Reed
Summary: Mutations in RNA/DNA-binding proteins can cause ALS, but the exact disease mechanisms are still unclear. This study found that a group of ALS-associated proteins can affect the expression of genes involved in the MHC II antigen presentation pathway. Additionally, hematopoietic progenitor cells with mutations also exhibit disrupted MHC II expression. These findings suggest that the loss of the MHC II pathway may result in the immune system's failure to protect motor neurons from ALS-related damage.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Oncology
Renato B. Baleeiro, Christian J. Bouwens, Peng Liu, Carmela Di Gioia, Louisa S. Chard Dunmall, Ai Nagano, Rathistevy Gangeswaran, Claude Chelala, Hemant M. Kocher, Nicholas R. Lemoine, Yaohe Wang
Summary: The expression of MHC II on PDAC cells contributes to the cytotoxicity of CD4+ and CD8+ T-cells against these cells. Stimulation of CD4+ T-cells with neo-antigens can lead to recognition and killing of PDAC cells expressing mutated genes. Combination treatment with IFN-gamma and/or MEK/HDAC inhibitors can induce tumoral MHC II expression on MHC II-negative tumors that are resistant to IFN-gamma. Harnessing MHC II expression on PDAC cells for neo-antigen-based immunotherapy shows potential.
Article
Biochemistry & Molecular Biology
M. Cortazar-Chinarro, A. Richter-Boix, P. Rodin-Morch, P. Halvarsson, J. B. Logue, A. Laurila, J. Hoglund
Summary: Microbiomes play a crucial role in determining the ecology and behavior of their hosts. This study investigated the effects of geography, evolutionary history, and host genetics on the skin microbiome diversity and structure in a widespread amphibian. The results showed that microbiome diversity was correlated with host genetic diversity, and the bacterial community composition varied between geographical clusters and specific host genetic variations.
Article
Multidisciplinary Sciences
Maciej J. J. Lazarczyk, Brett A. A. Eyford, Merina Varghese, Hitesh Arora, Lonna Munro, Tahia Warda, Cheryl G. G. Pfeifer, Allison Sowa, Daniel R. R. Dickstein, Timothy Rumbell, Wilfred A. A. Jefferies, Dara L. L. Dickstein
Summary: MHC-I proteins are expressed in neurons and regulate synaptic plasticity, but their mechanisms in the CNS are still unknown. This study provides the first structural analysis of a MHC-I protein, revealing its underlying mechanisms in the brain. The Y321F mutation of MHC-I affects spine density and synaptic structure in the hippocampus, without impacting neuronal complexity, and mimics the phenotype of MHC-I knock-out animals, suggesting a crucial role of reverse, outside-in signaling events in regulating synaptic plasticity.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Ayano Inoue, Masashi Watanabe, Takeshi Kondo, Satoshi Hirano, Shigetsugu Hatakeyama
Summary: There has been a remarkable breakthrough in cancer treatment, particularly in the field of checkpoint blockade immunotherapy. Recent studies have shown that TRIM22 negatively regulates MHC-II expression and inhibiting TRIM22 can increase MHC-II expression in cancer cells, which may provide a therapeutic target to enhance immunotherapy effectiveness.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Elena Shklovskaya, Helen Rizos
Summary: It is well acknowledged that the immune system plays a role in controlling tumor growth, but tumors can escape immune surveillance through mechanisms like downregulation or loss of MHC-I molecules. This review examines the dysregulation of MHC-I expression in cancer, the nature of MHC-I-bound antigenic peptides, and discusses therapeutic strategies to address MHC-I deficiency in solid tumors with a focus on NK cells and CD4 T cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Caleb Y. Kim, Heather L. Parrish, Michael S. Kuhns
Summary: This study investigates the effects of a Ca C-strand mutation on the development and function of mouse CD4+ T cells. The results show an increase in single-positive thymocytes bearing mutant TCRs, as well as an increase in naive CD4+ T cells experiencing strong TCR signals and responding to cognate pMHC class II. These findings suggest that the unique Ca domain plays a significant role in fine-tuning TCR signaling.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Caleb Y. Kim, Heather L. Parrish, Michael S. Kuhns
Summary: The Cα domain of αβTCR plays a crucial role in fine-tuning TCR signaling and regulating the response to self-pMHC II interactions. Mutation in the Cα domain results in increased CD4(+) T cell numbers and enhanced response to pMHC II antigens.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Yanan Wu, Nianzhi Zhang, Keiichiro Hashimoto, Chun Xia, Johannes M. Dijkstra
Summary: The structures of peptide-loaded major histocompatibility complex class I (pMHC-I) and class II (pMHC-II) complexes are similar, but there are differences in the components. Comparative analysis of primitive vertebrate species' pMHC-I and pMHC-II structures sheds light on the evolution of MHC structures. The establishment of pMHC-I involved the development of important new functions that have been well conserved since their early inception.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Richel J. C. Bilderbeek, Maksim V. Baranov, Geert van den Bogaart, Frans Bianchi
Summary: This study reveals the over-presentation of membrane protein fragments in cytolytic and helper T cell responses. It also demonstrates the evolutionary conservation and lower frequency of mutations in transmembrane helices, suggesting that T cells are more tuned to respond to membrane proteins to avoid evasion by pathogens.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Ludovica Marinelli, Camille Martin-Gallausiaux, Jean-Marie Bourhis, Fabienne Beguet-Crespel, Herve M. Blottiere, Nicolas Lapaque
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Xufei Zhang, Alexandra Grosfeld, Edek Williams, Daniel Vasiliauskas, Sharon Barretto, Lorraine Smith, Mahendra Mariadassou, Catherine Philippe, Fabienne Devime, Chloe Melchior, Guillaume Gourcerol, Nathalie Dourmap, Nicolas Lapaque, Pierre Larraufie, Herve M. Blottiere, Christine Herberden, Philippe Gerard, Jens F. Rehfeld, Ronaldo P. Ferraris, J. Christopher Fritton, Sandrine Ellero-Simatos, Veronique Douard
Article
Immunology
Matthieu Million, Maxime Gaudin, Clea Melenotte, Lionel Chasson, Sophie Edouard, Constance Verdonk, Elsa Prudent, Bernard Amphoux, Stephane Meresse, Richard Dorent, Hubert Lepidi, Bernard La Scola, Jean-Pierre Gorvel, Christelle Desnues, Didier Raoult
CLINICAL INFECTIOUS DISEASES
(2020)
Article
Cell Biology
Clara Degos, Lisiena Hysenaj, Gabriela Gonzalez-Espinoza, Vilma Arce-Gorvel, Aurelie Gagnaire, Alexia Papadopoulos, Karina Alejandra Pasquevich, Stephane Meresse, Juliana Cassataro, Sylvie Memet, Jean-Pierre Gorvel
CELLULAR MICROBIOLOGY
(2020)
Article
Cell Biology
Lucrecia Alberdi, Alexandra Vergnes, Jean-Baptiste Manneville, Dumizulu L. Tembo, Ziyan Fang, Yaya Zhao, Nina Schroeder, Audrey Dumont, Margaux Lagier, Patricia Bassereau, Lorena Redondo-Morata, Jean-Pierre Gorvel, Stephane Meresse
JOURNAL OF CELL SCIENCE
(2020)
Article
Nutrition & Dietetics
Camille Martin-Gallausiaux, Ludovica Marinelli, Herve M. Blottiere, Pierre Larraufie, Nicolas Lapaque
Summary: This article discusses the mechanisms and impact of short-chain fatty acids (SCFA) on gut functions, host immunity, and human health. SCFA, derived from bacterial fermentation of dietary fibers, serve as important fuels for intestinal epithelial cells and modulate various functions to impact intestinal homeostasis.
PROCEEDINGS OF THE NUTRITION SOCIETY
(2021)
Article
Microbiology
Fernando Chimal-Cazares, Gabriela Hernandez-Martinez, Sabino Pacheco, Miguel A. Ares, Jorge Soria-Bustos, Manuel Sanchez-Gutierrez, Jeannett A. Izquierdo-Vega, Jose Antonio Ibarra, Jorge A. Gonzalez-Y-Merchand, Jean-Pierre Gorvel, Stephane Meresse, Miguel A. De la Cruz
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Microbiology
Vinicius de Rezende Rodovalho, Brenda Silva Rosa da Luz, Houem Rabah, Fillipe Luiz Rosa do Carmo, Edson Luiz Folador, Aurelie Nicolas, Julien Jardin, Valerie Briard-Bion, Herve Blottiere, Nicolas Lapaque, Gwenael Jan, Yves Le Loir, Vasco Ariston de Carvalho Azevedo, Eric Guedon
FRONTIERS IN MICROBIOLOGY
(2020)
Review
Cell Biology
Jona Karam, Stephane Meresse, Laurent Kremer, Wassim Daher
CELLULAR MICROBIOLOGY
(2020)
Article
Multidisciplinary Sciences
Thanida Laopanupong, Pinidphon Prombutara, Phongthon Kanjanasirirat, Salisa Benjaskulluecha, Atsadang Boonmee, Tanapat Palaga, Stephane Meresse, Jiraporn Paha, Tegar Adriansyah Putra Siregar, Tanawadee Khumpanied, Suparerk Borwornpinyo, Angkana Chaiprasert, Pongsak Utaisincharoen, Marisa Ponpuak
Summary: This study showed that specific genes such as Kxd1 and Plekhm2 are upregulated in macrophages infected with autophagy-resistant Beijing strain of Mycobacterium tuberculosis, compared to those infected with the reference strain H37Rv, leading to suppression of lysosome positioning and delivery during starvation-induced autophagy. These genes play a crucial role in allowing the BJN strain to evade autophagic restriction and survive within host cells.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Ziyan Fang, Mathieu Fallet, Thomas Moest, Jean-Pierre Gorvel, Stephane Meresse
Summary: In this study, it was found that the microtubule molecular motor KIF1B beta plays a key role in the establishment of the Salmonella replication niche, and its absence affects the stability of bacterial vacuoles and the formation of associated tubules. Kinesin-3 interacts with the Salmonella effector SifA and the host protein complex SKIP. The presence of SifA establishes a recruitment pathway for kinesin-1 and kinesin-3 in infected cells.
JOURNAL OF CELL SCIENCE
(2022)
Article
Neurosciences
Zehra Esra Ilhan, Vincent Brochard, Nicolas Lapaque, Stephane Auvin, Patricia Lepage
Summary: Anti-seizure medications can affect the gut microbiota and have different impacts on the growth of gut bacterial strains. The toxicity of medication ingredients varies and can also affect gut epithelial cells. Gut microbial metabolites may play a role in mediating the interaction between medications and epithelial cells.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Multidisciplinary Sciences
S. Holbert, E. Barilleau, S. M. Roche, J. Trotereau, S. Georgeault, J. Burlaud-Gaillard, A. Wiedemann, S. Meresse, I Virlogeux-Payant, P. Velge
Summary: Numerous studies have shown that the Salmonella Pathogenicity Island 1-encoded type III secretion system (T3SS1) apparatus and its associated effectors play a key role in the invasion and intracellular fate of Salmonella in host cells. Some cell lines have been identified where Salmonella Typhimurium can enter without using its three known invasion factors. In the murine AML12 hepatocyte cell line, the T3SS1 mutant induced an intracellular fate similar to the wild-type strain, indicating that invasion and survival of Salmonella Typhimurium can be independent of T3SS1.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Xufei Zhang, Magali Monnoye, Mahendra Mariadassou, Fabienne Beguet-Crespel, Nicolas Lapaque, Christine Heberden, Veronique Douard
Summary: The study revealed different impacts of fructose and glucose intake on mice, with glucose leading to increased adiposity, glucose intolerance, and intestinal permeability, while fructose resulted in elevated IL6 levels. The research also identified the potential roles of microbiota composition and inflammatory factors in gut barrier function and inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Camille Martin-Gallausiaux, Diego Garcia-Weber, Amandine Lashermes, Pierre Larraufie, Ludovica Marinelli, Veronica Teixeira, Alice Rolland, Fabienne Beguet-Crespel, Vincent Brochard, Timothe Quatremare, Alexandre Jamet, Joel Dore, Scott D. Gray-Owen, Herve M. Blottiere, Cecile Arrieumerlou, Nicolas Lapaque
Summary: The gut microbiota has an impact on the health of the host through interactions with intestinal epithelial cells. It has been found that the commensal bacterium A. muciniphila promotes intestinal homeostasis by activating the ALPK1/TIFA/TRAF6 axis, a pathway associated with innate immunity.