Article
Immunology
Chloe D. Goldsmith, Thomasina Donovan, Nicole Vlahovich, David B. Pyne
Summary: This perspective article discusses how exercise can delay T cell ageing by analyzing the relationship between metabolism and epigenetics, proposing a potential impact of exercise on CD4+ T cell plasticity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Wanxue He, Kun Xiao, Jiaruo Xu, Wei Guan, Sheling Xie, Kaifei Wang, Peng Yan, Min Fang, Lixin Xie
Summary: Sepsis is a life-threatening disease caused by infection, with recurrent sepsis exacerbating CD4(+) T cell exhaustion and reducing antiviral immune responses, leading to increased disease severity and mortality.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Kan Yang, Keyi Nong, Fei Xu, Yu Chen, Jinying Yu, Lizhi Lin, Xiao Hu, Youzhi Wang, Ting Li, Jibin Dong, Jinxin Wang
Summary: In this study, a series of benzene-heterocyclic-based ASM inhibitors were designed, synthesized, and screened, and some compounds showed favorable inhibitory activity against recombinant human ASM. Compound 4i exhibited good pharmacokinetic properties and in vivo inhibitory activity against ASM, reducing the level of ceramide in mice plasma and liver. Moreover, 4i was found to decrease lipid plaques, plasma ceramide concentration, and Ox-LDL levels, and to regulate cell inflammation induced by LPS and Ox-LDL by modulating the levels of ceramide and sphingomyelin. Overall, this study demonstrates the potential of ASM as an effective target for treating atherosclerosis.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Immunology
Muhammad Daud, Prasad Dasari, Marion Adelfinger, Daniela Langenhorst, Jasmin Lother, Dragana Slavkovic-Lukic, Carsten Berges, Michaela Kruhm, Annette Galler, Cathrin Schleussner, Christian H. Luther, Karl Alberter, Anton Althammer, Haroon Shaikh, Niklas Pallmann, Jochen Bodem, Mohammed El-Mowafy, Andreas Beilhack, Marcus Dittrich, Max S. Topp, Peter F. Zipfel, Niklas Beyersdorf
Summary: To gain a better understanding of life-threatening fungal infections caused by Candida albicans, our study conducted in silico screening to identify protein interactions between the fungus and the host. We discovered that the human CD4 binds to the C. albicans protein enolase 1 (Eno1), which affects the immune response and cytokine secretion. This interaction modulates CD4(+) T-cell responses, favoring the fungus.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Editorial Material
Immunology
Laura M. Snell
Summary: This study reveals a progenitor T cell subset that plays a crucial role in maintaining immune responses during chronic infection by generating effector and follicular helper T cells.
Article
Multidisciplinary Sciences
Florian Mair, Jami R. Erickson, Marie Frutoso, Andrew J. Konecny, Evan Greene, Valentin Voillet, Nicholas J. Maurice, Anthony Rongvaux, Douglas Dixon, Brittany Barber, Raphael Gottardo, Martin Prlic
Summary: Immunotherapies have shown great success in cancer treatment, but face challenges. Current treatment approaches target pathways not only in tumors but also in other tissues, complicating treatment. Single-cell analysis revealed significant overlap in immune cell composition and phenotype between tumors and inflamed tissues.
Article
Immunology
Miwa Sasai, Ji Su Ma, Masaaki Okamoto, Kohei Nishino, Hikaru Nagaoka, Eizo Takashima, Ariel Pradipta, Youngae Lee, Hidetaka Kosako, Pann-Ghill Suh, Masahiro Yamamoto
Summary: The TCR signaling in CD8(+) T cells is qualitatively different from that in CD4(+) T cells due to the involvement of PLC beta 4. PLC beta 4 plays a crucial role in activating CD8(+) T cells and promoting adaptive immunity, while deficiency of PLC beta 4 leads to impaired immune responses in CD8(+) T cells.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Immunology
Sandra Hellberg, Johanna Raffetseder, Olof Rundquist, Rasmus Magnusson, Georgia Papapavlou, Maria C. Jenmalm, Jan Ernerudh, Mika Gustafsson
Summary: The changes in progesterone levels during and after pregnancy influence the course of autoimmune diseases such as multiple sclerosis and rheumatoid arthritis, possibly through immune-endocrine interactions. Study findings indicate that P4 significantly suppresses CD4(+) T cell activation, impacting gene and protein expression profiles and showing potential for regulating immune responses. These results suggest a role for P4 in immune modulation during pregnancy and highlight the importance of further research on its potential as a treatment option for pregnancy-induced diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Reiner K. Mailer, Sandra Konrath, Lydia Zhan, Hanna Thode, Manu Beerens, Maike Frye, Daniel F. J. Ketelhuth, Thomas Renne, Goeran K. Hansson
Summary: Inflammation caused by LDL deposition in the arterial wall leads to atherosclerosis. Regulatory T cells inhibit vascular inflammation by inducing immune tolerance towards LDL-related antigens. However, the mechanisms that promote the generation of LDL-specific regulatory T cells in vivo are still unclear.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zibing Wang, Yuqing Liu, Ling Peng, Brian Till, Yuwei Liao, Shumin Yuan, Xiang Yan, Lin Chen, Qiang Fu, Zhihai Qin
Summary: The role of B cells in the anti-tumor immune response is controversial. An increase in the number of B cells in the peripheral blood of some tumor patients has been associated with poor immunotherapy efficacy. This study suggests that CD11b(+) myeloid cells promote B cell proliferation, activation, and survival, and targeting B cells may increase the efficacy of immunotherapy in tumor-bearing hosts.
Review
Gastroenterology & Hepatology
Neda Yahoo, Michael Dudek, Percy Knolle, Mathias Heikenwaelder
Summary: The liver plays a central role in metabolism and immune functions. When overwhelmed by obesity and a sedentary lifestyle, it can lead to the development of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Genetic and environmental factors, including the gut microbiome, also contribute to the development and progression of NAFLD and liver cancer. CD8+CXCR6+PD1+ T cells are implicated in the transition from NASH to hepatocellular carcinoma (HCC), and their characteristics may affect responses to immune checkpoint inhibitors. This review focuses on the role of T cells in NASH and discusses preventive measures and therapeutic strategies for managing NASH-HCC.
JOURNAL OF HEPATOLOGY
(2023)
Article
Immunology
Brandilyn A. Peters, Jee-Young Moon, David B. Hanna, Olaf Kutsch, Margaret Fischl, Caitlin A. Moran, Adaora A. Adimora, Stephen Gange, Nadia R. Roan, Katherine G. Michel, Michael Augenbraun, Anjali Sharma, Alan Landay, Seema Desai, Robert C. Kaplan
Summary: Persistent CD4(+) T-cell activation and exhaustion may contribute to increased long-term mortality risk in women with HIV, independent of HIV disease progression.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Immunology
Quentin Le Hingrat, Irini Sereti, Alan L. Landay, Ivona Pandrea, Cristian Apetrei
Summary: CD4(+) T-cell depletion is a key feature of AIDS in both HIV and SIV infections, occurring early and being most significant at mucosal sites. The clinical outcome is associated with mucosal CD4(+) T-cell recovery during chronic infection, while immune activation and inflammation play critical roles in CD4(+) T-cell depletion.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kue Peng Lim, Nur Syafinaz Zainal
Summary: With the regulatory approval of Provenge and T-VEC for the treatment of metastatic prostate cancer and advanced melanoma respectively, and other promising clinical trials outcomes, cancer vaccine is gaining prominence as a cancer therapeutic agent.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Microbiology
Jerome Kervevan, Aurelie Bouteau, Juliane S. Lanza, Adele Hammoudi, Sandra Zurawski, Mathieu Surenaud, Lydie Dieudonne, Marion Bonnet, Cecile Lefebvre, Hakim Hocini, Romain Marlin, Aurelie Guguin, Barbara Hersant, Oana Hermeziu, Elisabeth Menu, Christine Lacabaratz, Jean-Daniel Lelievre, Gerard Zurawski, Veronique Godot, Sandrine Henri, Botond Z. Igyarto, Yves Levy, Sylvain Cardinaud
Summary: Targeting of skin Langerhans cells (LC) may efficiently induce potent anti-HIV immune responses, serving as a promising strategy for developing effective HIV-1 vaccines. This approach demonstrates the potential of directing immune responses through specific cell targeting and may lead to the induction of protective antibodies against HIV-1.