Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF)

Mutant p53 stimulates chemoresistance of pancreatic adenocarcinoma cells to gemcitabine

(2015) Claudia Fiorini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome

(2015) Paul M. Neilsen et al.   Oncotarget

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

(2014) Patricia A.J. Muller et al.   CANCER CELL

A common p53 mutation (R175H) activates c-Met receptor tyrosine kinase to enhance tumor cell invasion

(2013) Katharine D Grugan et al.   CANCER BIOLOGY & THERAPY

Wild-type and mutant p53 mediate cisplatin resistance through interaction and inhibition of active caspase-9

(2013) Jacqueline L.Y. Chee et al.   CELL CYCLE

Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis

(2013) W Hanel et al.   CELL DEATH AND DIFFERENTIATION

Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells

(2013) S Masciarelli et al.   ONCOGENE

Functions of TAp63 and p53 in restraining the development of metastatic cancer

(2013) E H Tan et al.   ONCOGENE

Mutant p53-R273H gains new function in sustained activation of EGFR signaling via suppressing miR-27a expression

(2013) W Wang et al.   Cell Death & Disease

Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion

(2012) Cynthia R Coffill et al.   EMBO REPORTS

Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature

(2012) Hilla Solomon et al.   JOURNAL OF CELL SCIENCE

Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion

(2012) P A J Muller et al.   ONCOGENE

Ionizing radiation induces a dramatic persistence of p53 protein accumulation and DNA damage signaling in mutant p53 zebrafish

(2012) L Guo et al.   ONCOGENE

A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer

(2011) Javier E. Girardini et al.   CANCER CELL

MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function

(2011) S Donzelli et al.   CELL DEATH AND DIFFERENTIATION

Mutant p53 gain of function is interwoven into the hallmarks of cancer

(2011) Hilla Solomon et al.   JOURNAL OF PATHOLOGY

Rapamycin synergizes cisplatin sensitivity in basal-like breast cancer cells through up-regulation of p73

(2010) Su Wei Wong et al.   BREAST CANCER RESEARCH AND TREATMENT

BRCA1-Associated Epigenetic Regulation of p73 Mediates an Effector Pathway for Chemosensitivity in Ovarian Carcinoma

(2010) N. Ibrahim et al.   CANCER RESEARCH

Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy

(2010) Gianluca Bossi et al.   CELL CYCLE

Displacement of Bim by Bmf and Puma rather than increase in Bim level mediates paclitaxel-induced apoptosis in breast cancer cells

(2010) O Kutuk et al.   CELL DEATH AND DIFFERENTIATION

The role of mutant p53 in human cancer

(2010) Amanda M Goh et al.   JOURNAL OF PATHOLOGY

p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma

(2010) Brendan Doyle et al.   JOURNAL OF PATHOLOGY

Mutant p53 initiates a feedback loop that involves Egr-1/EGF receptor/ERK in prostate cancer cells

(2010) L Sauer et al.   ONCOGENE

Mutant p53 mediates survival of breast cancer cells

(2009) L Y Lim et al.   BRITISH JOURNAL OF CANCER

Mutant p53 Drives Invasion by Promoting Integrin Recycling

(2009) Patricia A.J. Muller et al.   CELL

A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

(2009) Maddalena Adorno et al.   CELL

The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis

(2009) Giulia Fontemaggi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

(2009) M. Olivier et al.   Cold Spring Harbor Perspectives in Biology

Suppression of Inhibitor of Differentiation 2, a Target of Mutant p53, Is Required for Gain-of-Function Mutations

(2008) W. Yan et al.   CANCER RESEARCH