T-cell intracellular antigens function as tumor suppressor genes

Genome-wide profiling reveals a role for T-cell intracellular antigens TIA1 and TIAR in the control of translational specificity in HeLa cells

(2015) Isabel Carrascoso et al.   BIOCHEMICAL JOURNAL

Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance

(2014) Maryam A. Hamdollah Zadeh et al.   Molecular Oncology

Identification of a set of miRNAs differentially expressed in transiently TIA-depleted HeLa cells by genome-wide profiling

(2013) Carmen Sánchez-Jiménez et al.   BMC MOLECULAR BIOLOGY

Another fork in the road—life or death decisions by the tumour suppressor p53

(2013) Luis A Carvajal et al.   EMBO REPORTS

A compendium of RNA-binding motifs for decoding gene regulation

(2013) Debashish Ray et al.   NATURE

IntOGen-mutations identifies cancer drivers across tumor types

(2013) Abel Gonzalez-Perez et al.   NATURE METHODS

T-cell Intracellular Antigen (TIA)-Proteins Deficiency in Murine Embryonic Fibroblasts Alters Cell Cycle Progression and Induces Autophagy

(2013) Carmen Sánchez-Jiménez et al.   PLoS One

Pre-mRNA processing factors meet the DNA damage response

(2013) Alessandra Montecucco et al.   Frontiers in Genetics

Cancer statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Nuclear Pore Component Nup98 Is a Potential Tumor Suppressor and Regulates Posttranscriptional Expression of Select p53 Target Genes

(2012) Stephan Singer et al.   MOLECULAR CELL

Knockdown of T-cell intracellular antigens triggers cell proliferation, invasion and tumour growth

(2011) José M. Izquierdo et al.   BIOCHEMICAL JOURNAL

Is post-transcriptional stabilization, splicing and translation of selective mRNAs a key to the DNA damage response?

(2011) H. Christian Reinhardt et al.   CELL CYCLE

Translational coregulation of 5'TOP mRNAs by TIA-1 and TIAR

(2011) C. K. Damgaard et al.   GENES & DEVELOPMENT

Nucleoporins Directly Stimulate Expression of Developmental and Cell-Cycle Genes Inside the Nucleoplasm

(2010) Bernike Kalverda et al.   CELL

Heterogeneous ribonucleoprotein C displays a repressor activity mediated by T-cell intracellular antigen-1-related/like protein to modulate Fas exon 6 splicing through a mechanism involving Hu antigen R

(2010) José M. Izquierdo   NUCLEIC ACIDS RESEARCH

Impaired Embryonic Development in Mice Overexpressing the RNA-Binding Protein TIAR

(2010) Yacine Kharraz et al.   PLoS One

TIA-1 Cytotoxic Granule-Associated RNA Binding Protein Improves the Prognostic Performance of CD8 in Mismatch Repair-Proficient Colorectal Cancer

(2010) Inti Zlobec et al.   PLoS One

TIAR and TIA-1 mRNA-Binding Proteins Co-aggregate under Conditions of Rapid Oxygen Decline and Extreme Hypoxia and Suppress the HIF-1  Pathway

(2010) O. R. Gottschald et al.   Journal of Molecular Cell Biology

iCLIP Predicts the Dual Splicing Effects of TIA-RNA Interactions

(2010) Zhen Wang et al.   PLOS BIOLOGY

Posttranscriptional regulation of cancer traits by HuR

(2010) Kotb Abdelmohsen et al.   Wiley Interdisciplinary Reviews-RNA

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

RNA granules: post-transcriptional and epigenetic modulators of gene expression

(2009) Paul Anderson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alternative polyadenylation variants of the RNA binding protein, HuR: abundance, role of AU-rich elements and auto-Regulation

(2009) Wijdan Al-Ahmadi et al.   NUCLEIC ACIDS RESEARCH

Depletion of T-cell intracellular antigen proteins promotes cell proliferation

(2009) Raquel Reyes et al.   GENOME BIOLOGY

The ratio of ±KTS splice variants of the Wilms’ tumour suppressor protein WT1 mRNA is determined by an intronic enhancer

(2008) Cheng Yang et al.   Biochemistry and Cell Biology

Hu Antigen R (HuR) Functions as an Alternative Pre-mRNA Splicing Regulator of Fas Apoptosis-promoting Receptor on Exon Definition

(2008) José M. Izquierdo   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY