期刊
BIOCHEMICAL JOURNAL
卷 461, 期 -, 页码 43-50出版社
PORTLAND PRESS LTD
DOI: 10.1042/BJ20140227
关键词
gene expression control; T-cell intracellular antigen 1 (TIA1); TIA1-related protein (TIAR); translation
资金
- Ministerio de Economia y Competitividad of the Fondo Europeo de Desarrollo Regional (FEDER) [BFU2008-00354, BFU2011-29653]
- Fundacion Ramon Areces, Spain
TIA (T-cell intracellular antigens)-knockdown HeLa cells show an increase in ribosomes and translational machinery components. This increase correlates with specific changes in translationally up-regulated mRNAs involved in cell-cycle progression and DNA repair, as shown in polysomal profiling analysis. Our data support the hypothesis that a concerted activation of both global and selective translational rates leads to the transition to a more proliferative status in TIA-knockdown HeLa cells.
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