Article
Biochemistry & Molecular Biology
Dong Man Jang, Eun Kyung Oh, Hyunggu Hahn, Hyoun Sook Kim, Byung Woo Han
Summary: This study reports the crystal structure of human full-length Bfk, revealing its canonical Bcl-2 fold but lacking the hydrophobic cleft. Molecular dynamics simulation and biophysical interaction analysis demonstrate that Bfk elicits its pro-apoptotic activity through a Bid-like apoptotic mechanism.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Review
Plant Sciences
Haiyan Ding, Qiang You, Dan Li, Youping Liu
Summary: This review summarizes the recent research progress of 5-Demethylnobiletin (5DN), a polymethoxyflavone primarily found in citrus fruits, including its pharmacological activity, mechanism of action, pharmacokinetics, and toxicological effects. 5DN has broad pharmacological activities, with anti-inflammatory effects, apoptosis and autophagy promotion, and induction of melanogenesis. The metabolites of 5DN, particularly 5,3'-dideme-thylnobiletin (M1), show better activity than 5DN for cancer treatment. However, further in vivo studies are needed to explore the potential of 5DN and its metabolites as drug candidates.
Review
Medicine, General & Internal
Ji Tu, Jose Vargas Castillo, Abhirup Das, Ashish D. Diwan
Summary: Degenerative Cervical Myelopathy (DCM) is a common and serious neurological disorder caused by chronic compression or irritation of the spinal cord in the neck, leading to neck pain and impaired motor function. Decompressive surgery is the most effective treatment, but timing for the procedure remains a challenge due to poor prognosis and limited understanding of its molecular mechanisms.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Judith Morawietz, Hanna Koerber, Eva-Maria Packeiser, Andreas Beineke, Sandra Goericke-Pesch
Summary: Chronic asymptomatic orchitis (CAO) is a common cause of acquired non-obstructive azoospermia in dogs. The study found that the disturbance of spermatogenesis in CAO is correlated with an increase in TUNEL+ cells. Gene expression analysis revealed increased levels of Bax, Bcl-2, caspase 9, Fas, caspase 8, and caspase 3 in CAO, while FasL expression was downregulated. Sertoli cells and B lymphocytes play a significant role in the pathophysiology of canine CAO.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Wenxia Zhan, Yi Li, Jie Yuan, Na Zhi, Yiyuan Huang, Yingqi Liu, Ming Zhang, Shengxi Wu, Xianghui Zhao
Summary: This article reviews the progress of studies on the roles of TET proteins and 5hmC patterns in neurobiology and psychiatric disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Christopher A. Waudby, Saul Alvarez-Teijeiro, E. Josue Ruiz, Simon Suppinger, Nikos Pinotsis, Paul R. Brown, Axel Behrens, John Christodoulou, Anastasia Mylona
Summary: Protein phosphorylation regulates cellular signaling, and the phosphorylation of c-JUN at multiple sites controls various functional states in signal response.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Parishmita Sarma, Carlo Marion C. Carino, Deeksha Seetharama, Shubhi Pandey, Hemlata Dwivedi-Agnihotri, Xue Rui, Yubo Cao, Kouki Kawakami, Poonam Kumari, Yu-Chih Chen, Kathryn E. Luker, Prem N. Yadav, Gary D. Luker, Stephane A. Laporte, Xin Chen, Asuka Inoue, Arun K. Shukla
Summary: Chemokine receptors are G protein-coupled receptors (GPCRs) involved in immune responses and characterized by ligand promiscuity. Here, the authors characterize signaling through chemokine receptors CXCR4 and CXCR7, with insights into intrinsic-bias encoded in the CXCR4-CXCR7 system.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Hideo Ando, Yoshihide Nakao
Summary: In this study, the [Li+@C-60]PF6- salt was theoretically investigated, revealing that at temperatures below 24 K, Li+ ions are localized at two equivalent disordered sites, while below that temperature, a disorder-order transition occurs and the Li+ ions are mostly localized at one of the two disordered sites. It was found that the weak distortions of the C-60 cage and the PF6- coordination sphere, as well as the inversion-symmetry breaking, affect intermolecular interactions, leading to the two-site disorder-order transition.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Review
Biochemistry & Molecular Biology
Hongmei Zheng, Yue Ning, Yuting Zhan, Sile Liu, Qiuyuan Wen, Songqing Fan
Summary: PD-1 and its ligands PD-L1/PD-L2 play important roles in tumor immune evasion, while PD-1 could also activate signaling pathways in tumor cells to promote tumor growth. PD-1 is expressed in certain tumors and is associated with patient prognosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ankita Poojari, Kapil Dev, Atefeh Rabiee
Summary: Lipedema is a fat and fascia disorder primarily affecting women. The mechanisms underlying this condition and its treatment options are not well understood. This review explores the morphological phenotype of lipedema fat, its pathophysiology, and potential biomarkers, while emphasizing the importance of technological interventions in the future.
Article
Chemistry, Physical
Yuxin Dai, Xiaoli Zhang, Yu Cui, Mengyuan Li, Yao Luo, Fan Jiang, Renqiang Zhao, Yucheng Huang
Summary: A series of structural analogues MXs with intrinsic built-in electric field have been proposed and demonstrated to be thermodynamically, dynamically and mechanically stable. These MXs show versatile electronic properties and large piezoelectric coefficients, making them promising for optoelectronic and piezoelectric device applications.
Article
Materials Science, Ceramics
Zong-Yan Zhao, Jia-Xin Zhang, Xian-Lan Chen
Summary: This study systematically investigates the formation of intrinsic point defects of Delafossite CuAlO2 and their effects on optical absorption spectra and electronic structure, providing an important theoretical basis for its significant role in optoelectronic applications.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Huilong Yu, Shuaipeng Wang, Ruizhi Qiu, Gan Li, Haibo Li, Xin Xiang, Wenhua Luo
Summary: In this study, intrinsic point defects in PuO2 were systematically investigated, and it was found that the antisite atoms O-Pu and Pu-O are more likely to appear in O-rich and O-deficient environments, respectively. New types of Schottky defects and Frenkel defects were proposed, and the most stable configurations of these defects were predicted.
Review
Immunology
Kyle J. Bednar, Jee Ho Lee, Tatiana Ort
Summary: CD4 (+) CD25 (high) Foxp3 (+) regulatory T-cells (Tregs) play a crucial role in maintaining immune homeostasis and tolerance. This review summarizes the concept of Treg cell stability and plasticity, as well as the underlying molecular mechanisms, including translational and epigenetic regulators, which may contribute to the development of new therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Physics, Multidisciplinary
Huiying Liu, Jianzhou Zhao, Yue-Xin Huang, Weikang Wu, Xian-Lei Sheng, Cong Xiao, Shengyuan A. Yang
Summary: The study investigates the intrinsic properties of anomalous Hall effect in magnets, revealing an intrinsic band geometric property associated with Berry-connection polarizability in momentum space. The intrinsic effect dominates in antiferromagnets with PT symmetry, exhibiting sensitive dependence on the Neel vector orientation with a 2 pi periodicity. This offers a new route for electric detection of magnetic order in PT-invariant antiferromagnets.
PHYSICAL REVIEW LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Javier Oroz, Susana Barrera-Vilarmau, Carlos Alfonso, German Rivas, Eva de Alba
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Multidisciplinary Sciences
Matteo De March, Nekane Merino, Susana Barrera-Vilarmau, Ramon Crehuet, Silvia Onesti, Francisco J. Blanco, Alfredo De Biasio
NATURE COMMUNICATIONS
(2017)
Article
Biochemistry & Molecular Biology
Laura S. Zamorano, Susana Barrera Vilarmau, Juan B. Arellano, Galina G. Zhadan, Nazaret Hidalgo Cuadrado, Sergey A. Bursakov, Manuel G. Roig, Valery L. Shnyrov
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2009)
Article
Biochemistry & Molecular Biology
Matteo De March, Susana Barrera-Vilarmau, Emmanuele Crespan, Elisa Mentegari, Nekane Merino, Amaia Gonzalez-Magana, Miguel Romano-Moreno, Giovanni Maga, Ramon Crehuet, Silvia Onesti, Francisco J. Blanco, Alfredo De Biasio
NUCLEIC ACIDS RESEARCH
(2018)
Article
Multidisciplinary Sciences
Lorenzo Sborgi, Susana Barrera-Vilarmau, Patricia Obregon, Eva de Alba
Article
Multidisciplinary Sciences
Marija Sorokina, Joao M. C. Teixeira, Susana Barrera-Vilarmau, Reinhard Paschke, Ioannis Papasotiriou, Joao P. G. L. M. Rodrigues, Panagiotis L. Kastritis
Article
Biochemical Research Methods
Joao P. G. L. M. Rodrigues, Susana Barrera-Vilarmau, Joao M. C. Teixeira, Marija Sorokina, Elizabeth Seckel, Panagiotis L. Kastritis, Michael Levitt
PLOS COMPUTATIONAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Nicolas S. Gonzalez-Foutel, Juliana Glavina, Wade M. Borcherds, Matias Safranchik, Susana Barrera-Vilarmau, Amin Sagar, Alejandro Estana, Amelie Barozet, Nicolas A. Garrone, Gregorio Fernandez-Ballester, Clara Blanes-Mira, Ignacio E. Sanchez, Gonzalo De Prat-Gay, Juan Cortes, Pau Bernado, Rohit Pappu, Alex S. Holehouse, Gary W. Daughdrill, Lucia B. Chemes
Summary: This study identifies the molecular mechanism of functional selection in disordered proteins and highlights the importance of conformational buffering and motif-linker coevolution for functional encoding.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Susana Barrera-Vilarmau, Joao M. C. Teixeira, Monika Fuxreiter
Summary: This article discusses protein interactions in the cellular environment, exploring the evolution of views on protein interactions and addressing open problems related to biomolecular condensates. Recent discoveries highlight the need for a universal framework for protein interactions that can be applied to different scales of protein communities. The study demonstrates the importance of considering the cellular context and multiple binding modes in understanding protein interactions, and suggests a physics-based approach to modeling cellular protein behaviors.
ESSAYS IN BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Andras Hatos, Joao M. C. Teixeira, Susana Barrera-Vilarmau, Attila Horvath, Silvio C. E. Tosatto, Michele Vendruscolo, Monika Fuxreiter
Summary: Proteins form complex interactions in the cellular environment. The FuzPred server predicts their binding modes based on sequence without specifying the binding partners. The server also estimates the multiplicity of binding modes and visualizes different interaction behaviors on protein structures.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Multidisciplinary Sciences
Monika Gonczi, Joao M. C. Teixeira, Susana Barrera-Vilarmau, Laura Mediani, Francesco Antoniani, Tamas Milan Nagy, Krisztina Feher, Zsolt Raduly, Viktor Ambrus, Jozsef Tozser, Endre Barta, Katalin E. Kover, Laszlo Csernoch, Serena Carra, Monika Fuxreiter
Summary: The context-dependent higher-order assembly of Mef2D controls muscle lineage development by simultaneously interacting with the basal machinery and myogenic factors. The study found that the alternatively spliced acidic beta-domain enhances the transcription of Mef2D. The beta-domain can serve as an interaction element for higher-order assembly, forming nuclear condensates and solid-like aggregates. These findings suggest that the beta-domain fine-tunes Mef2D assembly and provides a platform for myogenic regulatory factors and transcriptional apparatus during muscle development.
NATURE COMMUNICATIONS
(2023)