Article
Biophysics
Amanda Cristina Zangirolami, Fernanda Carbinatto, Jose Dirceu Vollet Filho, Vanderlei Salvador Bagnato, Kate Cristina Blanco
Summary: The study demonstrates that curcuminoids and Photogem formulations combined with light illumination can effectively inhibit the formation and infection of bacterial biofilms. Curcuminoid formulations show better inhibition of Staphylococcus aureus biofilms, while Photogem formulations show better inhibition of Escherichia coli biofilms.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
F. Boschetto, T. Honma, T. Adachi, N. Kanamura, W. Zhu, T. Yamamoto, E. Marin, G. Pezzotti
Summary: This study assessed the effects of incorporating curcumin into PMMA bone cements at different concentrations. It was found that curcumin can enhance cellular adhesion and bone tissue formation, improving the bioactive properties of PMMA and promoting bone regeneration. Curcumin can be considered as a cost-effective additive with potential applications in bone repair.
MATERIALS TODAY CHEMISTRY
(2023)
Review
Cell Biology
Maryam Mahjoob, Ursula Stochaj
Summary: This review discusses the potential of different forms of nano-curcumin in treating or preventing age-related health issues. However, there are inherent barriers that still need to be overcome to ensure the efficacy and safety of nano-curcumin in alleviating aging-related health problems.
AGEING RESEARCH REVIEWS
(2021)
Review
Agricultural Engineering
Li Yixuan, Majjid A. Qaria, Sethupathy Sivasamy, Sun Jianzhong, Zhu Daochen
Summary: The article introduces the medicinal value of curcumin and its production methods, including extraction, purification, synthesis, etc., and discusses the role of nanotechnology delivery systems in improving the bioavailability of curcumin. It also points out the problems of curcumin in pharmaceutical applications and the future prospects for development.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Nutrition & Dietetics
Ester Cisneros Aguilera, Annick Vachon, Melanie Plourde
Summary: Curcuminoids, derived from turmeric spice, have low bioavailability in the human plasma due to their lipophilic properties. To increase bioavailability, a natural product combined curcuminoids with esterified omega-3 fatty acids. In a young population, the product showed higher pharmacokinetics and increased curcuminoids concentration in plasma compared to other formulations.
Article
Integrative & Complementary Medicine
Chunping Wan, Qinge Ma, Samantha Anderson, Qi-Hui Zhang, Chun-Feng Zhang, Angela H. Wang, Emma Bell, Lifei Hou, Chun-Su Yuan, Chong-Zhi Wang
Summary: Colorectal cancer is a major cause of cancer-related death in the U.S., and chronic gut inflammation increases the risk of its development. Turmeric, particularly its active constituent curcumin, has shown potential anticancer properties. In this study, a surfactant-formulated curcumin was used to enhance its bioavailability and its chemopreventive activities were evaluated.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
John Amalraj, Claudia E. Vergara, Matias Monroy-Cardenas, Ramiro Araya-Maturana, Maximiliano Martinez-Cifuentes
Summary: This study investigated the electrochemical behavior of N-methyl and N-benzyl-4-piperidone curcumin analogs experimentally and theoretically. Results showed different outcomes in the two compounds during the two-electron irreversible oxidation process, with M06 DFT calculations providing more accurate predictions of oxidation potentials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Timothy M. Panknin, Carol L. Howe, Meg Hauer, Bhanu Bucchireddigari, Anthony M. Rossi, Janet L. Funk
Summary: This scoping review assessed human clinical trials on the effects of oral curcumin on disease outcomes. Results showed beneficial effects on clinical outcomes and biomarkers in obesity-associated metabolic disorders and musculoskeletal disorders. However, studies on neurocognitive disorders, gastrointestinal disorders, and cancer had mixed results. Further research, including systematic evaluation of different curcumin formulations and larger trials, is needed. The current evidence suggests clinical benefits for highly studied diseases such as metabolic syndrome and osteoarthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Li Ma, Hongxia Gao, Ce Cheng, Mengmeng Cao, Liqiang Zou, Wei Liu
Summary: This study aims to enhance the antioxidant activity and absorption performance of curcumin through stabilized emulsions. The results show that the emulsions stabilized with curcumin nanosuspensions have good thermal and centrifugal stability, and can reduce the oxidation degree of algal oil.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Marta Ximenis, Jose Mulet, Salvador Sala, Francisco Sala, Manuel Criado, Rosario Gonzalez-Muniz, Maria Jesus Perez de Vega
Summary: This study evaluated a range of natural products and synthetic compounds, finding that phloretin, demethoxycurcumin, and bis-demethoxicurcuming act as positive allosteric modulators (PAMs) of α7 nAChR; and some new curcumin derivatives have the ability to enhance ACh-evoked signal, with tetrahydrocurcuminoid analog 23 showing particularly promising activity values.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
K. Vasanth Kumar, Claire Heffernan, Kiran A. Ramisetty, Christopher A. Howard, Sergey Beloshapkin
Summary: This study demonstrates the potential of using Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS) to simultaneously quantify the distribution of structurally-similar impurities on the surface of crystals. The results provide new information that can help to understand the crystallisation process.
Article
Biochemistry & Molecular Biology
Marco A. Obregon-Mendoza, William Meza-Morales, Yair Alvarez-Ricardo, M. Mirian Estevez-Carmona, Raul G. Enriquez
Summary: In this study, an optimized synthesis of curcumin and symmetric curcuminoids was reported. The use of a cyclic difluoro-boronate derivative of acetylacetone prepared by reaction of 2,4-pentanedione with boron trifluoride in THF resulted in good to excellent yields. Subsequent cleavage of the BF2 group using hydrated alumina or silica oxides allowed for the direct filtration of the target heptanoids in high yields. Furthermore, crystallization provided an efficient purification step. The present methodology offers a simple, versatile, fast, and economical synthetic alternative for obtaining curcumin, bis-demethoxycurcumin, and symmetrical heterocyclic curcuminoids in pure form and excellent yields.
Article
Food Science & Technology
Camila Helena Facina, Silvana Gisele Pegorin Campos, Thalles Fernando Rocha Ruiz, Rejane Maira Goes, Patricia Simone Leite Vilamaior, Sebastiao Roberto Taboga
Summary: Curcumin and piperine can mitigate the detrimental effects of BPA on the prostate gland, reducing nuclear atypia and maintaining the homeostasis of prostate epithelial cells. The protective action of these phytotherapeutic agents is associated with weight loss, anti-inflammatory potential, and control of prostate epithelial cell homeostasis.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mahshid Ataei, Basil D. Roufogalis, Muhammed Majeed, Muhammad A. Shah, Amirhossein Sahebkar
Summary: Curcumin nanofibers, prepared using electrospinning, have shown improved bioavailability compared to free curcumin. Although most studies have been conducted in vitro, curcumin nanofibers have demonstrated superior efficacy in various cancer types and have the potential to enhance cancer treatment. Further preclinical and clinical studies are needed to evaluate their anticancer activity.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Amir R. Afshari, Mohammad Jalili-Nik, Farzaneh Abbasinezhad-Moud, Hossein Javid, Mohammad Karimi, Hamid Mollazadeh, Tannaz Jamialahmadi, Thozhukat Sathyapalan, Amirhossein Sahebkar
Summary: Curcuminoids, extracted from Curcuma Longa, have shown promising therapeutic benefits in experimental studies against GBM by modulating various signaling pathways and molecular targets. They exert anti-GBM effects through regulation of angiogenesis, receptor tyrosine kinases, Sonic Hedgehog, and NF-kappa B, suggesting their potential for clinical translation.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Agriculture, Dairy & Animal Science
H. Sadri, S. Daenicke, Ulrich Meyer, J. Rehage, J. Frank, H. Sauerwein
JOURNAL OF DAIRY SCIENCE
(2015)
Article
Biochemistry & Molecular Biology
Stephanie Hagl, Dirk Berressem, Bastian Bruns, Nadine Sus, Jan Frank, Gunter P. Eckert
Article
Biochemistry & Molecular Biology
Stephanie Hagl, Alexa Kocher, Christina Schiborr, Natalie Kolesova, Jan Frank, Gunter P. Eckert
NEUROCHEMISTRY INTERNATIONAL
(2015)
Article
Neurosciences
Stephanie Hagl, Dirk Berressem, Rehka Grewal, Nadine Sus, Jan Frank, Gunter P. Eckert
NUTRITIONAL NEUROSCIENCE
(2016)
Article
Biochemistry & Molecular Biology
Ali A. Moazzami, Sonja Frank, Antonin Gombert, Nadine Sus, Banu Bayram, Gerald Rimbach, Jan Frank
Article
Oncology
Nicola Bortel, Sorin Armeanu-Ebinger, Evi Schmid, Bettina Kirchner, Jan Frank, Alexa Kocher, Christina Schiborr, Steven Warmann, Joerg Fuchs, Verena Ellerkamp
Review
Oncology
Christian Busch, Markus Burkard, Christian Leischner, Ulrich M. Lauer, Jan Frank, Sascha Venturelli
CLINICAL EPIGENETICS
(2015)
Article
Food Science & Technology
Alexa Kocher, Laura Bohnert, Christina Schiborr, Jan Frank
MOLECULAR NUTRITION & FOOD RESEARCH
(2016)
Article
Neurosciences
Stephanie Hagl, Heike Asseburg, Martina Heinrich, Nadine Sus, Eva-Maria Blumrich, Ralf Dringen, Jan Frank, Gunter P. Eckert
NEUROMOLECULAR MEDICINE
(2016)
Review
Nutrition & Dietetics
Sascha Venturelli, Markus Burkard, Martin Biendl, Ulrich M. Lauer, Jan Frank, Christian Busch
Article
Oncology
Stephan Duetzmann, Christina Schiborr, Alexa Kocher, Ulrich Pilatus, Elke Hattingen, Jakob Weissenberger, Florian Gessler, Johanna Quick-Weller, Kea Franz, Volker Seifert, Jan Frank, Christian Senft
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2016)
Article
Agriculture, Multidisciplinary
Banu Bayram, Gerald Runbach, Jan Frank, Tuba Esatbeyoglu
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Maren C. Podszun, Nadine Grebenstein, Astrid Spruss, Thomas Schlueter, Claus Kremoser, Ina Bergheim, Jan Frank
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Dawn Chin, Patricia Huebbe, Jan Frank, Gerald Rimbach, Kathrin Pallauf