The established and emerging roles of astrocytes and microglia in amyotrophic lateral sclerosis and frontotemporal dementia

Astrocytic TYMP and VEGFA drive blood–brain barrier opening in inflammatory central nervous system lesions

(2015) Candice Chapouly et al.   BRAIN

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Human-derived neural progenitors functionally replace astrocytes in adult mice

(2015) Hong Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

(2015) Axel Freischmidt et al.   NATURE NEUROSCIENCE

The Glymphatic System: A Beginner’s Guide

(2015) Nadia Aalling Jessen et al.   NEUROCHEMICAL RESEARCH

Impairment of paravascular clearance pathways in the aging brain

(2014) Benjamin T. Kress et al.   ANNALS OF NEUROLOGY

Frontotemporal dementia: a bridge between dementia and neuromuscular disease

(2014) Adeline S.L. Ng et al.   Annals of the New York Academy of Sciences

Focality, stochasticity and neuroanatomic propagation in ALS pathogenesis

(2014) John Ravits   EXPERIMENTAL NEUROLOGY

Pathogenesis/genetics of frontotemporal dementia and how it relates to ALS

(2014) Janis Bennion Callister et al.   EXPERIMENTAL NEUROLOGY

Evaluation of 2-[18F]fluoroacetate Kinetics in Rodent Models of Cerebral Hypoxia–Ischemia

(2014) Yu Ouyang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Profiling the genes affected by pathogenic TDP-43 in astrocytes

(2014) Cao Huang et al.   JOURNAL OF NEUROCHEMISTRY

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury

(2014) Jeffrey J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Neuroimaging in amyotrophic lateral sclerosis: insights into structural and functional changes

(2014) Adriano Chiò et al.   LANCET NEUROLOGY

Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models

(2014) S Sakura Minami et al.   NATURE MEDICINE

Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS

(2014) Diane B. Re et al.   NEURON

Norepinephrine Controls Astroglial Responsiveness to Local Circuit Activity

(2014) Martin Paukert et al.   NEURON

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

(2014) Ashley E. Frakes et al.   NEURON

Fine-tuning the central nervous system: microglial modelling of cells and synapses

(2014) A. L. Xavier et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Transcellular degradation of axonal mitochondria

(2014) Chung-ha O. Davis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

(2014) E. A. Winkler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis

(2014) C. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

(2014) G. Kleinberger et al.   Science Translational Medicine

Progranulin in neurodegenerative disease

(2014) Terri L. Petkau et al.   TRENDS IN NEUROSCIENCES

TREM2Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis

(2014) Janet Cady et al.   JAMA Neurology

Focal Transplantation of Human iPSC-Derived Glial-Rich Neural Progenitors Improves Lifespan of ALS Mice

(2014) Takayuki Kondo et al.   Stem Cell Reports

Loss of TDP-43 causes age-dependent progressive motor neuron degeneration

(2013) Yohei Iguchi et al.   BRAIN

Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats

(2013) Jianbin Tong et al.   EMBO JOURNAL

Cerebral Arterial Pulsation Drives Paravascular CSF-Interstitial Fluid Exchange in the Murine Brain

(2013) J. J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Angiogenin induces modifications in the astrocyte secretome: Relevance to amyotrophic lateral sclerosis

(2013) Alexandra Skorupa et al.   Journal of Proteomics

Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer

(2013) Lijun Yang et al.   Journal of Translational Medicine

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

(2013) Sruti Rayaprolu et al.   Molecular Neurodegeneration

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

(2013) Won-Suk Chung et al.   NATURE

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

Aquaporin water channels in the nervous system

(2013) Marios C. Papadopoulos et al.   NATURE REVIEWS NEUROSCIENCE

The changing scene of amyotrophic lateral sclerosis

(2013) Wim Robberecht et al.   NATURE REVIEWS NEUROSCIENCE

Heterozygous TREM2 mutations in frontotemporal dementia

(2013) Barbara Borroni et al.   NEUROBIOLOGY OF AGING

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

(2013) Shuo-Chien Ling et al.   NEURON

Molecular Imaging of Microglial Activation in Amyotrophic Lateral Sclerosis

(2013) Philippe Corcia et al.   PLoS One

Autophagy Adaptor Protein p62/SQSTM1 and Autophagy-Related Gene Atg5 Mediate Autophagosome Formation in Response to Mycobacterium tuberculosis Infection in Dendritic Cells

(2013) Shintaro Seto et al.   PLoS One

Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS

(2013) K. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reactive astrocytes secrete lcn2 to promote neuron death

(2013) F. Bi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain

(2013) Vinita Rangroo Thrane et al.   Scientific Reports

Deciphering amyotrophic lateral sclerosis: What phenotype, neuropathology and genetics are telling us about pathogenesis

(2013) John Ravits et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Using Exome Sequencing to Reveal Mutations in TREM2 Presenting as a Frontotemporal Dementia–like Syndrome Without Bone Involvement

(2013) Rita João Guerreiro et al.   JAMA Neurology

The genetics and neuropathology of amyotrophic lateral sclerosis

(2012) Ammar Al-Chalabi et al.   ACTA NEUROPATHOLOGICA

The genetics and neuropathology of frontotemporal lobar degeneration

(2012) Anne Sieben et al.   ACTA NEUROPATHOLOGICA

Mouse models of frontotemporal dementia

(2012) Erik D. Roberson   ANNALS OF NEUROLOGY

Impaired blood–brain/spinal cord barrier in ALS patients

(2012) Svitlana Garbuzova-Davis et al.   BRAIN RESEARCH

Detection of microbleeds in post-mortem brains of patients with frontotemporal lobar degeneration: a 7.0-Tesla magnetic resonance imaging study with neuropathological correlates

(2012) J. De Reuck et al.   EUROPEAN JOURNAL OF NEUROLOGY

Changes in the astrocytic aquaporin-4 and inwardly rectifying potassium channel expression in the brain of the amyotrophic lateral sclerosis SOD1G93Arat model

(2012) Danijela Bataveljić et al.   GLIA

Targeted Depletion of TDP-43 Expression in the Spinal Cord Motor Neurons Leads to the Development of Amyotrophic Lateral Sclerosis-like Phenotypes in Mice

(2012) Lien-Szu Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease

(2012) Azeb Tadesse Argaw et al.   JOURNAL OF CLINICAL INVESTIGATION

Motoneurons Secrete Angiogenin to Induce RNA Cleavage in Astroglia

(2012) A. Skorupa et al.   JOURNAL OF NEUROSCIENCE

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis

(2012) Chi-Hong Wu et al.   NATURE

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Microglial activation and TDP-43 pathology correlate with executive dysfunction in amyotrophic lateral sclerosis

(2011) Johannes Brettschneider et al.   ACTA NEUROPATHOLOGICA

Progranulin Is a Chemoattractant for Microglia and Stimulates Their Endocytic Activity

(2011) Fiona Pickford et al.   AMERICAN JOURNAL OF PATHOLOGY

Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis

(2011) Michael A. van Es et al.   ANNALS OF NEUROLOGY

Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments

(2011) Vivek Swarup et al.   BRAIN

Ras-related GTPases Rap1 and RhoA Collectively Induce the Phagocytosis of Serum-opsonized Zymosan Particles in Macrophages

(2011) Jae-Gyu Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB–mediated pathogenic pathways

(2011) Vivek Swarup et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuropathology of Frontotemporal Lobar Degeneration-Tau (FTLD-Tau)

(2011) Dennis W. Dickson et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

(2011) Thomas Philips et al.   LANCET NEUROLOGY

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

(2011) Amanda M Haidet-Phillips et al.   NATURE BIOTECHNOLOGY

Clinical diagnosis and management of amyotrophic lateral sclerosis

(2011) Orla Hardiman et al.   Nature Reviews Neurology

VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD

(2010) Emilie Tresse et al.   Autophagy

Progranulin expression in the developing and adult murine brain

(2010) Terri L. Petkau et al.   JOURNAL OF COMPARATIVE NEUROLOGY

TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia

(2010) Ian RA Mackenzie et al.   LANCET NEUROLOGY

Behavioural-variant frontotemporal dementia: diagnosis, clinical staging, and management

(2010) Olivier Piguet et al.   LANCET NEUROLOGY

Nasu-Hakola disease: The first case reported by Nasu and review

(2010) Minoru Kaneko et al.   NEUROPATHOLOGY

Rethinking ALS: The FUS about TDP-43

(2009) Clotilde Lagier-Tourenne et al.   CELL

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

(2009) Hristelina Ilieva et al.   JOURNAL OF CELL BIOLOGY

Lipocalin-2 Is an Autocrine Mediator of Reactive Astrocytosis

(2009) S. Lee et al.   JOURNAL OF NEUROSCIENCE

PET of Glial Metabolism Using 2-18F-Fluoroacetate

(2009) J. Marik et al.   JOURNAL OF NUCLEAR MEDICINE

P3-392: The dopaminergic neurotransmitter system is associated with aggression and agitation in frontotemporal dementia

(2008) Sebastiaan Engelborghs et al.   Alzheimers & Dementia

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN

The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis

(2008) Angeles Duran et al.   CANCER CELL

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

(2008) Zhihui Zhong et al.   NATURE NEUROSCIENCE

Developmental Regulation of TREM2 and DAP12 Expression in the Murine CNS: Implications for Nasu-Hakola Disease

(2008) J. Cameron Thrash et al.   NEUROCHEMICAL RESEARCH