Numerical Simulations Reveal Randomness of Cu(II) Induced Aβ Peptide Dimerization under Conditions Present in Glutamatergic Synapses

Resistance of Cu(Aβ4- 16) to Copper Capture by Metallothionein-3 Supports a Function for the Aβ4- 42 Peptide as a Synaptic CuII Scavenger

(2016) Nina E. Wezynfeld et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

A Functional Role for Aβ in Metal Homeostasis? N-Truncation and High-Affinity Copper Binding

(2015) Mariusz Mital et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amyloid β Protein and Alzheimer’s Disease: When Computer Simulations Complement Experimental Studies

(2015) Jessica Nasica-Labouze et al.   CHEMICAL REVIEWS

Qualitative changes in human γ-secretase underlie familial Alzheimer’s disease

(2015) Maria Szaruga et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Introduction of a Fluorescent Probe to Amyloid-β to Reveal Kinetic Insights into Its Interactions with Copper(II)

(2014) Thomas Branch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In vivo-folded metal-metallothionein 3 complexes reveal the Cu-thionein rather than Zn-thionein character of this brain-specific mammalian metallothionein

(2014) Ester Artells et al.   FEBS Journal

An integrated study of the affinities of the Aβ16 peptide for Cu(i) and Cu(ii): implications for the catalytic production of reactive oxygen species

(2014) Tessa R. Young et al.   Metallomics

N-truncated amyloid β (Aβ) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits

(2013) Yvonne Bouter et al.   ACTA NEUROPATHOLOGICA

The intersection of amyloid beta and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease

(2013) Johanna L. Crimins et al.   AGEING RESEARCH REVIEWS

Biophysical Studies of the Amyloid β-Peptide: Interactions with Metal Ions and Small Molecules

(2013) Sebastian Wärmländer et al.   CHEMBIOCHEM

Role of Metal Ions in the Self-assembly of the Alzheimer’s Amyloid-β Peptide

(2013) Peter Faller et al.   INORGANIC CHEMISTRY

Alzheimer's Aβ42 and Aβ40 peptides form interlaced amyloid fibrils

(2013) Lei Gu et al.   JOURNAL OF NEUROCHEMISTRY

Evaluating Amyloid-β Oligomers in Cerebrospinal Fluid as a Biomarker for Alzheimer’s Disease

(2013) Mikko Hölttä et al.   PLoS One

Quantitative analysis of the time course of Aβ oligomerization and subsequent growth steps using tetramethylrhodamine-labeled Aβ

(2013) Kanchan Garai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance

(2013) Itender Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cu(II) Affinity for the Alzheimer’s Peptide: Tyrosine Fluorescence Studies Revisited

(2012) Bruno Alies et al.   ANALYTICAL CHEMISTRY

The Elevated Copper Binding Strength of Amyloid-β Aggregates Allows the Sequestration of Copper from Albumin: A Pathway to Accumulation of Copper in Senile Plaques

(2012) Dianlu Jiang et al.   BIOCHEMISTRY

Bioinorganic Chemistry of Alzheimer’s Disease

(2012) Kasper P. Kepp   CHEMICAL REVIEWS

Metal ions and amyloid fiber formation in neurodegenerative diseases. Copper, zinc and iron in Alzheimer's, Parkinson's and prion diseases

(2012) John H. Viles   COORDINATION CHEMISTRY REVIEWS

Coordination of redox active metal ions to the amyloid precursor protein and to amyloid-β peptides involved in Alzheimer disease. Part 1: An overview

(2012) Christelle Hureau   COORDINATION CHEMISTRY REVIEWS

pH-dependent kinetics of copper ions binding to amyloid-β peptide

(2012) Yannan Bin et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

The Heterogeneous Nature of Cu2+Interactions with Alzheimer’s Amyloid-β Peptide

(2011) Simon C. Drew et al.   ACCOUNTS OF CHEMICAL RESEARCH

Rapid Formation of a Preoligomeric Peptide-Metal-Peptide Complex Following Copper(II) Binding to Amyloid β Peptides

(2011) Jeppe T. Pedersen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Neuronal Death Induced by Nanomolar Amyloid β Is Mediated by Primary Phagocytosis of Neurons by Microglia

(2011) Urte Neniskyte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cu(II) Mediates Kinetically Distinct, Non-amyloidogenic Aggregation of Amyloid-β Peptides

(2011) Jeppe T. Pedersen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid oligomers: formation and toxicity of Aβ oligomers

(2010) Masafumi Sakono et al.   FEBS Journal

Ctr1 Is an Apical Copper Transporter in Mammalian Intestinal Epithelial Cellsin VivoThat Is Controlled at the Level of Protein Stability

(2010) Yasuhiro Nose et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substoichiometric Levels of Cu2+Ions Accelerate the Kinetics of Fiber Formation and Promote Cell Toxicity of Amyloid-β from Alzheimer Disease

(2010) Claire J. Sarell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetics of Amyloid β Monomer-to-Oligomer Exchange by NMR Relaxation

(2010) Nicolas L. Fawzi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper(II) Binding to Amyloid-β Fibrils of Alzheimer’s Disease Reveals a Picomolar Affinity: Stoichiometry and Coordination Geometry Are Independent of Aβ Oligomeric Form

(2009) Claire J. Sarell et al.   BIOCHEMISTRY

The Caenorhabditis elegans Aβ1–42Model of Alzheimer Disease Predominantly Expresses Aβ3–42

(2009) Gawain McColl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Role for Synaptic Zinc in Activity-Dependent A  Oligomer Formation and Accumulation at Excitatory Synapses

(2009) A. Deshpande et al.   JOURNAL OF NEUROSCIENCE

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

(2009) X. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Speciation analysis of selected metals and determination of their total contents in paired serum and cerebrospinal fluid samples: An approach to investigate the permeability of the human blood-cerebrospinal fluid-barrier

(2008) Volker Nischwitz et al.   ANALYTICA CHIMICA ACTA

The stochastic nature of biochemical networks

(2008) Vahid Shahrezaei et al.   CURRENT OPINION IN BIOTECHNOLOGY

Amyloid-  Peptide (A ) Neurotoxicity Is Modulated by the Rate of Peptide Aggregation: A  Dimers and Trimers Correlate with Neurotoxicity

(2008) L. W. Hung et al.   JOURNAL OF NEUROSCIENCE