Article
Environmental Sciences
Weixiang Wu, Xiaolin Ruan, Chunming Gu, Dan Luo, Jinfeng Ye, Fuqiang Diao, Lihong Wu, Mingyong Luo
Summary: Concerns about the adverse effects of metal/metalloids exposure on brain development and neurological disorders among children are increasing. This study investigated the transport patterns of 16 metals/metalloids across the blood-cerebrospinal fluid barrier (BCSFB) in children, and found that certain biomedical parameters could influence the transformation of metals/metalloids from serum to cerebrospinal fluid (CSF), highlighting their potential neurotoxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Biochemistry & Molecular Biology
Natalia Czarniak, Joanna Kaminska, Joanna Matowicka-Karna, Olga Martyna Koper-Lenkiewicz
Summary: Cerebrospinal fluid plays a crucial role in protecting the central nervous system by providing support, absorbing shocks, and transporting nutrients and waste products. This review provides an overview of cerebrospinal fluid history, production, circulation, main components, and the roles of blood-brain barrier and blood-cerebrospinal fluid barrier in maintaining homeostasis. The utility of Albumin Quotient evaluation in the diagnosis of CNS diseases is discussed. The importance of research on cerebrospinal fluid for improving disease management and discovering new treatment options is highlighted.
Review
Physiology
Jeff F. Dunn, Albert M. Isaacs
Summary: The blood-brain barrier, blood-cerebrospinal fluid barrier, and CSF-brain barriers are crucial for regulating the separation of nerves and glia from blood and CSF in the central nervous system. Hypoxia and inflammation can disrupt these barriers, impacting the overall health of the nervous system.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Review
Clinical Neurology
Roland Nau, Fritz Sorgel, Helmut Eiffert
Summary: Antimicrobial resistance poses a growing threat to patients, including those with nosocomial central nervous system infections. Optimizing intravenous treatment to achieve sufficient concentrations of antibiotics in different CNS compartments is crucial when causative pathogens have reduced sensitivity to antibiotics or the blood-brain barrier is mildly impaired. Adjusting antibiotic doses and exploring new combinations have shown promise in addressing antimicrobial resistance in CNS infections.
CURRENT OPINION IN NEUROLOGY
(2021)
Review
Nutrition & Dietetics
Shannon Morgan McCabe, Ningning Zhao
Summary: Manganese is an essential trace nutrient for life, but can become neurotoxic at high concentrations in the brain. The brain consists of two barriers - the blood-brain barrier (BBB) formed by endothelial cells and the blood-CSF barrier (BCB) formed by the choroid plexus - that prevent substances in the systemic circulation from reaching the brain and spinal cord. Studies have provided insights into manganese transport and metabolism in the brain, with a focus on the roles of the BBB and BCB in maintaining brain manganese homeostasis.
Article
Clinical Neurology
Eleonora Giacopuzzi Grigoli, Federica Solca, Ilaria Milone, Edoardo Nicolo Aiello, Antonella Dubini, Antonia Ratti, Erminio Torresani, Barbara Poletti, Nicola Ticozzi, Emilio Ciusani, Vincenzo Silani, Federico Verde
Summary: The CSF/serum albumin quotient is not specific to Alzheimer's disease and is not associated with disease stage, cognitive decline, or CSF AD biomarkers.
NEUROLOGICAL SCIENCES
(2023)
Article
Neurosciences
Yuying Cen, Yuheng Shan, Jiahua Zhao, Xiaojiao Xu, Zhiyong Nie, Jiatang Zhang
Summary: This study aimed to investigate the impact of major transporters at the blood-brain barrier and blood-cerebrospinal fluid barrier on the pharmacokinetics of levofloxacin in rats. The results showed that the efflux of levofloxacin from the central nervous system involves multi-drug resistance-associated proteins, breast cancer resistance protein, and organic anion transporters. The concentrations of levofloxacin in cerebrospinal fluid can be used as a surrogate to predict the concentrations inside the brain parenchyma.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Alexei Verkhratsky, Augustas Pivoriuas
Summary: The nervous system is protected and separated from the body by a complex system of barriers. In the central nervous system (CNS), these barriers include the blood-brain barrier and blood-spinal cord barrier, the arachnoid blood-cerebrospinal fluid barrier, the blood-cerebrospinal barrier of circumventricular organs, and the choroid plexus blood-cerebrospinal fluid barrier. In the peripheral nervous system, the barrier is maintained by tight junctions between specialized glial cells known as perineural cells. Astroglia contribute to all barriers in the CNS, and their dysfunction can compromise the integrity of these barriers.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Agriculture, Multidisciplinary
Natalia Platosz, Natalia Baczek, Joanna Topolska, Dorota Szawara-Nowak, Wieslaw Wiczkowski
Summary: This study aimed to verify the ability of different types of anthocyanins to cross the blood-cerebrospinal fluid barrier in sheep. The results showed that the penetration potential of chokeberry anthocyanins was higher than that of red cabbage anthocyanins, which could be largely attributed to the type and number of substituents as well as the size of the molecule.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Neurosciences
Yasuhiro Ogawa, Seioh Ezaki, Nobutake Shimojo, Satoru Kawano
Summary: The patient presented with various clinical symptoms of sepsis and after diagnosis and treatment, the orexin levels in the cerebrospinal fluid gradually recovered. This case provides new insights into the pathophysiology of sepsis-associated encephalopathy.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Martin Berghoff, Alexandra Hoepfinger, Ranjithkumar Rajendran, Thomas Karrasch, Andreas Schmid, Andreas Schaeffler
Summary: Data showed that METRNL is a neurotrophic myokine present in human cerebrospinal fluid and serum, with concentrations increasing with blood-brain barrier dysfunction.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Josephine A. Mapunda, Houyam Tibar, Wafa Regragui, Britta Engelhardt
Summary: Multiple Sclerosis (MS) is the most common inflammatory demyelinating disease of the central nervous system (CNS), with varying prevalence worldwide. Understanding how immune cells enter the CNS and the effects of immunomodulatory treatments on neuroinflammation is crucial. The brain barriers play a key role in regulating immune cell entry into the CNS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Sarinnapha M. Vasunilashorn, Long H. Ngo, Simon T. Dillon, Tamara G. Fong, Becky C. Carlyle, Pia Kivisakk, Bianca A. Trombetta, Kamen V. Vlassakov, Lisa J. Kunze, Steven E. Arnold, Zhongcong Xie, Sharon K. Inouye, Towia A. Libermann, Edward R. Marcantonio
Summary: In a study of older adults undergoing hip or knee surgery, it was found that surgery did not compromise the blood-brain barrier integrity. After surgery, there was a higher correlation between plasma and CSF levels of CRP and IL-6, with an increase in all three inflammatory markers from preoperative to postoperative 1 month.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
V. L. Cropley, M. Kittel, M. Heurich, M. Focking, F. M. Leweke, C. Pantelis
Summary: The study found that alterations in the complement system may be a feature of the early psychosis phenotype. Complement protein levels in blood were higher in individuals with first-episode psychosis and clinical high-risk for psychosis, while levels in cerebrospinal fluid did not differ significantly between groups. Serum protein levels were correlated with symptom severity in first-episode psychosis. Further studies are needed to investigate complement proteins in cerebrospinal fluid and their changes with progression of psychotic illness.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Immunology
Ronald J. Ellis, Scott Peterson, Mariana Cherner, Erin Morgan, Rachel Schrier, Bin Tang, Martin Hoenigl, Scott Letendre, Jenny Iudicello
Summary: This study suggests that cannabis may have a beneficial impact on HIV-associated blood-brain barrier (BBB) injury, with worse BBB index values correlated with higher levels of neural injury in cerebrospinal fluid (CSF). The findings support a potential therapeutic role of cannabis among people living with HIV (PWH) and may have important treatment implications for antiretroviral therapy (ART) effectiveness and toxicity.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Agronomy
Anna Missong, Roland Bol, Volker Nischwitz, Jaane Krueger, Friederike Lang, Jan Siemens, Erwin Klumpp
Article
Biochemistry & Molecular Biology
Lisa M. Galle, George E. Cutsail, Volker Nischwitz, Serena DeBeer, Ingrid Span
BIOLOGICAL CHEMISTRY
(2018)
Article
Anatomy & Morphology
Estibaliz Gonzalez de San Roman, Hans-Juergen Bidmon, Milena Malisic, Iuliana Susnea, Astrid Kueppers, Rene Huebbers, Andreas Wree, Volker Nischwitz, Katrin Amunts, Pitter F. Huesgen
BRAIN STRUCTURE & FUNCTION
(2018)
Article
Chemistry, Analytical
Volker Nischwitz, Nina Gottselig, Anna Missong, Erwin Klumpp, Melanie Braun
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2018)
Review
Chemistry, Analytical
Bjoern Meermann, Volker Nischwitz
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2018)
Article
Environmental Sciences
Anna Missong, Stefan Holzmann, Roland Bol, Volker Nischwitz, Heike Puhlmann, Klaus v. Wilpert, Jan Siemens, Erwin Klumpp
SCIENCE OF THE TOTAL ENVIRONMENT
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gregor Jost, Thomas Frenzel, Janina Boyken, Jessica Lohrke, Volker Nischwitz, Hubertus Pietsch
Article
Biochemistry & Molecular Biology
R. Mogwasi, D. K. Kariuki, M. Z. Getenga, V. Nischwitz
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2019)
Article
Chemistry, Analytical
Jingjing Yang, Ping Tan, Tianyin Huang, Volker Nischwitz
ANALYTICA CHIMICA ACTA
(2020)
Article
Environmental Sciences
N. Gottselig, J. Sohrt, D. Uhlig, V. Nischwitz, M. Weiler, W. Amelung
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Spectroscopy
Nicole Asante, Volker Nischwitz
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
(2020)
Article
Biochemical Research Methods
V Nischwitz, N. Gottselig, M. Braun
JOURNAL OF CHROMATOGRAPHY A
(2020)
Article
Chemistry, Analytical
Ping Tan, Jingjing Yang, Volker Nischwitz
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2020)
Article
Medicine, Research & Experimental
Filippo C. Michelotti, Gregory Bowden, Astrid Kueppers, Lieke Joosten, Jonas Maczewsky, Volker Nischwitz, Gisela Drews, Andreas Maurer, Martin Gotthardt, Andreas M. Schmid, Bernd J. Pichler
Article
Biochemistry & Molecular Biology
R. Mogwasi, S. Zor, D. K. Kariuki, M. Z. Getenga, V. Nischwitz
BIOLOGICAL TRACE ELEMENT RESEARCH
(2018)
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)