Natural Product Screening Reveals Naphthoquinone Complex I Bypass Factors

Mitochondrial complex I-linked disease

(2016) Richard J. Rodenburg   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Structure and function of mitochondrial complex I

(2016) Christophe Wirth et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

2-Methoxy-1,4-naphthoquinone (MNQ) induces apoptosis of A549 lung adenocarcinoma cells via oxidation-triggered JNK and p38 MAPK signaling pathways

(2015) Jeremy Yee Hoong Ong et al.   LIFE SCIENCES

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Border between natural product and drug: Comparison of the related benzoquinones idebenone and coenzyme Q10

(2015) Nuri Gueven et al.   Redox Biology

Chimaphilin induces apoptosis in human breast cancer MCF-7 cells through a ROS-mediated mitochondrial pathway

(2014) Wei-Dong Ma et al.   FOOD AND CHEMICAL TOXICOLOGY

PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling

(2014) V. A. Morais et al.   SCIENCE

Medical Management of Hereditary Optic Neuropathies

(2014) Chiara La Morgia et al.   Frontiers in Neurology

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Gene Knockout Using Transcription Activator-like Effector Nucleases (TALENs) Reveals That Human NDUFA9 Protein Is Essential for Stabilizing the Junction between Membrane and Matrix Arms of Complex I

(2012) David A. Stroud et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial disorders as windows into an ancient organelle

(2012) Scott B. Vafai et al.   NATURE

Features of Idebenone and Related Short-Chain Quinones that Rescue ATP Levels under Conditions of Impaired Mitochondrial Complex I

(2012) Michael Erb et al.   PLoS One

Vitamin K2 Is a Mitochondrial Electron Carrier That Rescues Pink1 Deficiency

(2012) M. Vos et al.   SCIENCE

The effects of idebenone on mitochondrial bioenergetics

(2011) Valentina Giorgio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Defective NDUFA9 as a novel cause of neonatally fatal complex I disease

(2011) B J C van den Bosch et al.   JOURNAL OF MEDICAL GENETICS

NQO1-Dependent Redox Cycling of Idebenone: Effects on Cellular Redox Potential and Energy Levels

(2011) Roman H. Haefeli et al.   PLoS One

Dehydro- -lapachone, a plant product with antivascular activity

(2011) I. Garkavtsev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA