Extracellular pH Modulates Neuroendocrine Prostate Cancer Cell Metabolism and Susceptibility to the Mitochondrial Inhibitor Niclosamide

N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells

(2016) John K. Lee et al.   CANCER CELL

The phenomenon of acquired resistance to metformin in breast cancer cells: The interaction of growth pathways and estrogen receptor signaling

(2016) Alexander M. Scherbakov et al.   IUBMB LIFE

Divergent targets of glycolysis and oxidative phosphorylation result in additive effects of metformin and starvation in colon and breast cancer

(2016) Cecilia Marini et al.   Scientific Reports

Correction: A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion

(2016) Magdalena L. Circu et al.   PLoS One

A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion

(2016) Magdalena L. Circu et al.   PLoS One

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy

(2015) Shari Pilon-Thomas et al.   CANCER RESEARCH

Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells

(2015) Arianna De Luca et al.   Oncotarget

Proposed Morphologic Classification of Prostate Cancer With Neuroendocrine Differentiation

(2014) Jonathan I. Epstein et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Multi-targeted therapy of cancer by niclosamide: A new application for an old drug

(2014) Yonghe Li et al.   CANCER LETTERS

Acquired resistance to metformin in breast cancer cells triggers transcriptome reprogramming toward a degradome-related metastatic stem-like profile

(2014) Cristina Oliveras-Ferraros et al.   CELL CYCLE

Aggressive Variants of Castration-Resistant Prostate Cancer

(2014) H. Beltran et al.   CLINICAL CANCER RESEARCH

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

Niclosamide ethanolamine–induced mild mitochondrial uncoupling improves diabetic symptoms in mice

(2014) Hanlin Tao et al.   NATURE MEDICINE

A Fluorescence-Coupled Assay for Gamma Aminobutyric Acid (GABA) Reveals Metabolic Stress-Induced Modulation of GABA Content in Neuroendocrine Cancer

(2014) Joseph E. Ippolito et al.   PLoS One

Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival

(2014) Mireille Khacho et al.   Nature Communications

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

(2013) V. Estrella et al.   CANCER RESEARCH

Acidosis Decreases c-Myc Oncogene Expression in Human Lymphoma Cells: A Role for the Proton-Sensing G Protein-Coupled Receptor TDAG8

(2013) Zhigang Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Suppression of Lysosome Function Induces Autophagy via a Feedback Down-regulation of MTOR Complex 1 (MTORC1) Activity

(2013) Min Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Catabolism of Exogenous Lactate Reveals It as a Legitimate Metabolic Substrate in Breast Cancer

(2013) Kelly M. Kennedy et al.   PLoS One

Autophagy on acid

(2012) Jonathan W. Wojtkowiak et al.   Autophagy

Chronic Autophagy Is a Cellular Adaptation to Tumor Acidic pH Microenvironments

(2012) Jonathan W. Wojtkowiak et al.   CANCER RESEARCH

A unifying theory of carcinogenesis, and why targeted therapy doesn’t work

(2012) Robert J. Gillies et al.   EUROPEAN JOURNAL OF RADIOLOGY

Links between metabolism and cancer

(2012) C. V. Dang   GENES & DEVELOPMENT

Structure-Activity Analysis of Niclosamide Reveals Potential Role for Cytoplasmic pH in Control of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling

(2012) Bruno D. Fonseca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The renaissance of mitochondrial pH

(2012) Jaime Santo-Domingo et al.   JOURNAL OF GENERAL PHYSIOLOGY

Systemic Buffers Inhibit Carcinogenesis in TRAMP Mice

(2012) Arig Ibrahim-Hashim et al.   JOURNAL OF UROLOGY

Niclosamide Is a Proton Carrier and Targets Acidic Endosomes with Broad Antiviral Effects

(2012) Andreas Jurgeit et al.   PLoS Pathogens

Bicarbonate and dichloroacetate: Evaluating pH altering therapies in a mouse model for metastatic breast cancer

(2011) Ian F Robey et al.   BMC CANCER

Reduction of metastasis using a non-volatile buffer

(2011) Arig Ibrahim Hashim et al.   CLINICAL & EXPERIMENTAL METASTASIS

Drug Resistance and Cellular Adaptation to Tumor Acidic pH Microenvironment

(2011) Jonathan W. Wojtkowiak et al.   MOLECULAR PHARMACEUTICS

Redeployment-based drug screening identifies the anti-helminthic niclosamide as anti-myeloma therapy that also reduces free light chain production

(2011) F L Khanim et al.   Blood Cancer Journal

Acidic stress promotes a glioma stem cell phenotype

(2010) A B Hjelmeland et al.   CELL DEATH AND DIFFERENTIATION

A mathematical model of tumour and blood pHe regulation: The buffering system

(2010) Natasha K. Martin et al.   MATHEMATICAL BIOSCIENCES

Cellular Metabolic Stress: Considering How Cells Respond to Nutrient Excess

(2010) Kathryn E. Wellen et al.   MOLECULAR CELL

Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases

(2009) I. F. Robey et al.   CANCER RESEARCH

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

(2009) R J DeBerardinis et al.   ONCOGENE

Acid treatment of melanoma cells selects for invasive phenotypes

(2008) Raymond E. Moellering et al.   CLINICAL & EXPERIMENTAL METASTASIS

Brick by brick: metabolism and tumor cell growth

(2008) Ralph J DeBerardinis et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Evaluation of lactate and alanine as metabolic biomarkers of prostate cancer using1H HR-MAS spectroscopy of biopsy tissues

(2008) May-Britt Tessem et al.   MAGNETIC RESONANCE IN MEDICINE