A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis

Matrix Rigidity Mediates TGFβ1-induced Epithelial-Myofibroblast Transition by Controlling Cytoskeletal Organization and MRTF-A Localization

(2015) Joseph W. O'Connor et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Myocardin related transcription factor A programs epigenetic activation of hepatic stellate cells

(2015) Wenfang Tian et al.   JOURNAL OF HEPATOLOGY

The regulation of gene expression during onset of differentiation by nuclear mechanical heterogeneity

(2014) Shefali Talwar et al.   BIOMATERIALS

MKL1/2 and ELK4 co-regulate distinct serum response factor (SRF) transcription programs in macrophages

(2014) Lan Xie   BMC GENOMICS

MRTF-A mediates LPS-induced pro-inflammatory transcription by interacting with the COMPASS complex

(2014) L. Yu et al.   JOURNAL OF CELL SCIENCE

Abnormally Differentiating Keratinocytes in the Epidermis of Systemic Sclerosis Patients Show Enhanced Secretion of CCN2 and S100A9

(2014) Joanna Nikitorowicz-Buniak et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Myocardin-Related Transcription Factor A Epigenetically Regulates Renal Fibrosis in Diabetic Nephropathy

(2014) H. Xu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Transforming growth factor β—at the centre of systemic sclerosis

(2014) Robert Lafyatis   Nature Reviews Rheumatology

RPEL Proteins Are the Molecular Targets for CCG-1423, an Inhibitor of Rho Signaling

(2014) Ken’ichiro Hayashi et al.   PLoS One

Megakaryocytic Leukemia 1 (MKL1) Regulates Hypoxia Induced Pulmonary Hypertension in Rats

(2014) Zhibin Yuan et al.   PLoS One

MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2

(2014) Rabea Hinkel et al.   Nature Communications

Fibroblasts in fibrosis: novel roles and mediators

(2014) Ryan T. Kendall et al.   Frontiers in Pharmacology

From tissue mechanics to transcription factors

(2013) Paul A. Janmey et al.   DIFFERENTIATION

LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation

(2013) Norihiko Sakai et al.   FASEB JOURNAL

The role of RhoA and cytoskeleton in myofibroblast transformation in hyperoxic lung fibrosis

(2013) Jixiang Ni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Novel Rho/MRTF/SRF Inhibitors Block Matrix-stiffness and TGF-β–Induced Fibrogenesis in Human Colonic Myofibroblasts

(2013) Laura A. Johnson et al.   INFLAMMATORY BOWEL DISEASES

Decoupling geometrical and chemical cues directing epidermal stem cell fate on polymer brush-based cell micro-patterns

(2013) Khooi Y. Tan et al.   Integrative Biology

Aortic Carboxypeptidase-like Protein (ACLP) Enhances Lung Myofibroblast Differentiation through Transforming Growth Factor β Receptor-dependent and -independent Pathways

(2013) Kathleen E. Tumelty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis

(2013) Yong Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct fibroblast lineages determine dermal architecture in skin development and repair

(2013) Ryan R. Driskell et al.   NATURE

Role of the extracellular matrix in regulating stem cell fate

(2013) Fiona M. Watt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Megakaryocytic leukemia 1 (MKL1) ties the epigenetic machinery to hypoxia-induced transactivation of endothelin-1

(2013) Yuyu Yang et al.   NUCLEIC ACIDS RESEARCH

Activation of MRTF-A-dependent gene expression with a small molecule promotes myofibroblast differentiation and wound healing

(2013) L. S. Velasquez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scleroderma pathogenesis: a pivotal role for fibroblasts as effector cells

(2013) Adrian J Gilbane et al.   ARTHRITIS RESEARCH & THERAPY

Editorial: Molecular Insights Into Systemic Sclerosis-Associated Interstitial Lung Disease

(2013) Richard M. Silver et al.   Arthritis & Rheumatology

Characterization and Role of SCAI during Renal Fibrosis and Epithelial-to-Mesenchymal Transition

(2012) Attila Fintha et al.   AMERICAN JOURNAL OF PATHOLOGY

Matrix Stiffness–Induced Myofibroblast Differentiation Is Mediated by Intrinsic Mechanotransduction

(2012) Xiangwei Huang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice

(2012) Takeya Minami et al.   EMBO JOURNAL

Extracellular-matrix tethering regulates stem-cell fate

(2012) Britta Trappmann et al.   NATURE MATERIALS

Cell-Cell Interactions Mediate the Response of Vascular Smooth Muscle Cells to Substrate Stiffness

(2011) Olga V. Sazonova et al.   BIOPHYSICAL JOURNAL

Myocardin-Related Transcription Factor A Mediates OxLDL-Induced Endothelial Injury

(2011) Fei Fang et al.   CIRCULATION RESEARCH

Nuclear transport of the serum response factor coactivator MRTF-A is downregulated at tensional homeostasis

(2011) Karen M McGee et al.   EMBO REPORTS

TGF-β-induced mesenchymal transition of MS-1 endothelial cells requires Smad-dependent cooperative activation of Rho signals and MRTF-A

(2011) Hajime Mihira et al.   JOURNAL OF BIOCHEMISTRY

Myocardin-related Transcription Factor-A Complexes Activate Type I Collagen Expression in Lung Fibroblasts

(2011) Larry L. Luchsinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myocardin-Related Transcription Factors A and B Are Key Regulators of TGF-β1-Induced Fibroblast to Myofibroblast Differentiation

(2011) Beverly J. Crider et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Fibrosis in systemic sclerosis: Emerging concepts and implications for targeted therapy

(2010) Jun Wei et al.   AUTOIMMUNITY REVIEWS

Myocardin-Related Transcription Factor-A Controls Myofibroblast Activation and Fibrosis in Response to Myocardial Infarction

(2010) Eric M. Small et al.   CIRCULATION RESEARCH

Force-induced Myofibroblast Differentiation through Collagen Receptors Is Dependent on Mammalian Diaphanous (mDia)

(2010) Matthew W. C. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

(2010) Fei Liu et al.   JOURNAL OF CELL BIOLOGY

Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions

(2010) John T. Connelly et al.   NATURE CELL BIOLOGY

Linking actin dynamics and gene transcription to drive cellular motile functions

(2010) Eric N. Olson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis

(2010) Nobuyo Higashi-Kuwata et al.   ARTHRITIS RESEARCH & THERAPY

Rac1 Expression by Fibroblasts Is Required for Tissue Repair in Vivo

(2009) Shangxi Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

Requirement of transforming growth factor β-activated kinase 1 for transforming growth factor β-induced α-smooth muscle actin expression and extracellular matrix contraction in fibroblasts

(2009) Xu Shi-Wen et al.   ARTHRITIS AND RHEUMATISM

Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423

(2009) Chris R. Evelyn et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The proadhesive phenotype of systemic sclerosis skin promotes myeloid cell adhesion via ICAM-1 and VCAM-1

(2009) B. J. Rabquer et al.   RHEUMATOLOGY

Role of the actin cytoskeleton in tuning cellular responses to external mechanical stress

(2009) M. B. Asparuhova et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Role of Rac1 in a bleomycin‐induced scleroderma model using fibroblast‐specific Rac1‐knockout mice

(2008) Shangxi Liu et al.   ARTHRITIS AND RHEUMATISM

Fibrosis in Systemic Sclerosis

(2008) John A. Varga et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Proteomic analysis of scleroderma lesional skin reveals activated wound healing phenotype of epidermal cell layer

(2008) N. Aden et al.   RHEUMATOLOGY