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Multidisciplinary Sciences
Adrianne Spencer, Andrew D. Sligar, Daniel Chavarria, Jason Lee, Darshil Choksi, Nikita P. Patil, HooWon Lee, Austin P. Veith, William J. Riley, Shubh Desai, Ali Abbaspour, Rohan Singeetham, Aaron B. Baker
Summary: The study found that mechanical forces can impact gene expression in breast cancer cells, affecting their proliferation, chemoresistance, and metastatic abilities. Mechanotransduction pathways play a role in regulating adhesion and survival signaling in breast cancer cells under mechanical load.
SCIENTIFIC REPORTS
(2021)
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Pathology
Junliang Li, Cheng Chen, Bo Chen, Tiankang Guo
Summary: This study investigated the expression pattern of FN1 in gastric cancer and its association with clinical characteristics, survival, MMR genes, and immune checkpoints. The results showed that high E-FN1 expression predicted poor overall survival, while high S-FN1 expression was associated with gastric cancer progression. FN1 expression was not correlated with MMR genes or immune checkpoints.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
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Cell Biology
Yang Liu, Ning Liu, Danfeng Xu, Baohui Wu, Xiaosheng Wu, Xia Sun, Yi Yang, Fengqin Yan
Summary: Hsa-miR-599 expression is downregulated in breast cancer tissues and cells, and is negatively correlated with TNM stage and lymph node metastasis. Enhanced hsa-miR-599 expression in breast cancer cells inhibits cell proliferation, migration, and invasion, and promotes cell apoptosis. Hsa-miR-599 may target BRD4 and inhibit breast cancer progression by targeting the Jagged1/Notch1 pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
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Cell Biology
Hui Yang, Wenguang Yuan, Wei Shang, Haoran Wang, Shanglei Ning, Ju Liu
Summary: Gastric cancer stem cells (GCSCs) are important in the initiation and development of gastric cancer (GC). Circular RNAs (circRNAs) have diverse functions in cancer biology, acting as tumor suppressors or oncogenes. This study focused on the expression profile and functional roles of circRNAs in GCSCs. Through enrichment of GCSCs using a spheroid formation assay, it was found that circSLC4A7 was one of the most upregulated circRNAs in GCSCs. Further experiments showed that circSLC4A7 promoted CSC-like properties and cell proliferation, migration, and invasion by interacting with HSP90 and activating the Notch1 signaling pathway in GC.
CELL DEATH & DISEASE
(2023)
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Pharmacology & Pharmacy
Xin Hua, Zhi-Qing Long, Ling Guo, Wen Wen, Xin Huang, Wen-Wen Zhang
Summary: High expression of IQGAP3 in breast cancer is associated with poor prognosis and radioresistance, suggesting it may serve as a reliable prognostic biomarker and aid in identifying patients who may benefit from radiotherapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Javeria Qadir, Syeda Kiran Riaz, Kiran Taj, Natasha Sattar, Namood-e Sahar, Jahangir Sarwar Khan, Mahmood Akhtar Kayani, Farhan Haq, Muhammad Faraz Arshad Malik
Summary: Breast cancer incidence is increasing globally, especially in countries with poor screening interventions, leading to delayed diagnosis and higher mortality rates. This study focused on the role of the YAP1 gene in breast cancer progression and metastasis, finding that YAP1 overexpression is associated with poor survival in Pakistani patients. Inhibition of YAP1 could be a potential therapeutic strategy for breast cancer treatment.
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Multidisciplinary Sciences
Nancy Guo, Aijun Yang, Fabiha Binte Farooq, Shreena Kalaria, Elena Moss, Lindsay DeVorkin, Mary Lesperance, Francois Benard, Don Wilson, Anna V. Tinker, Farouk S. Nathoo, Phineas T. Hamilton, Julian J. Lum
Summary: Unlike other epithelial ovarian carcinomas, clear cell ovarian carcinoma (CCOC) has a poor response to therapy. The expression of Carbonic anhydrase IX (CAIX) and CD8 + tumor-infiltrating lymphocytes (TILs) have distinct effects on the prognosis of CCOC patients. This study evaluates the relationship between CAIX, CD8, and survival in CCOC using imaging, transcriptome profiling, and histological analysis. The results suggest that hypoxia may contribute to immune exclusion in CCOC, primarily mediated by effects in the stromal regions.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Emilly Schlee Villodre, Xiaoding Hu, Bedrich L. Eckhardt, Richard Larson, Lei Huo, Ester C. Yoon, Yun Gong, Juhee Song, Shuying Liu, Naoto T. Ueno, Savitri Krishnamurthy, Stefan Pusch, Debu Tripathy, Wendy A. Woodward, Bisrat G. Debeb
Summary: This study found that NDRG1 drives tumor progression and brain metastasis in aggressive breast cancers and NDRG1-high expression correlates with worse clinical outcomes.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Pathology
Hongxing Nan, Lisha Zhou, Weihua Liang, Jin Meng, Ke Lin, Man Li, Jun Hou, Lianghai Wang
Summary: Elevated expression of CCL20 in esophageal cancer is associated with poor prognosis and metastatic potential, as well as with promoter hypomethylation in tumor cells. Imbalance among CD4(+) T cell subtypes and abnormal CCL20 expression in the tumor microenvironment are observed during tumorigenesis. Targeting CCL20 may be a promising therapeutic approach for esophageal cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
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Cell Biology
Yao Li, Xue Meng, Yuqing Luo, Shuai Luo, Jin Li, Jiafei Zeng, Xiang Huang, Jinjing Wang
Summary: The study found that miR-429 is overexpressed in triple-negative breast cancer and promotes the development of breast cancer by degrading the tumor suppressor DLC1.
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Cell Biology
Fangfang Chen, Shuai Yin, Bin Luo, Xiaoyan Wu, Honglin Yan, Dandan Yan, Chuang Chen, Feng Guan, Jingping Yuan
Summary: This study found that VDAC1 is inversely associated with Cytc in breast cancer, and the high expression of VDAC1 and low expression of Cytc are significantly correlated with clinical features and 5-year disease-free survival in BC.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Biology
Sumit Siddharth, Sheetal Parida, Nethaji Muniraj, Shawn Hercules, David Lim, Arumugam Nagalingam, Chenguang Wang, Balazs Gyorffy, Juliet M. Daniel, Dipali Sharma
Summary: African American women with TNBC have inherently aggressive cells with enriched GLI1 and Notch1 pathways compared to White American women. Inhibition of these pathways improves chemotherapy efficacy in AA-TNBC cells, suggesting a potential triple-combination therapy for improving outcomes in AA-TNBC.
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Biochemistry & Molecular Biology
Anxo Martinez-Ordonez, Samuel Seoane, Leandro Avila, Noemi Eiro, Manuel Macia, Efigenia Arias, Fabio Pereira, Tomas Garcia-Caballero, Noemi Gomez-Lado, Pablo Aguiar, Francisco Vizoso, Roman Perez-Fernandez
Summary: Metabolic reprogramming in breast cancer cells and fibroblasts is influenced by the transcription factor POU1F1 through its regulation of the LDHA gene, leading to increased cancer progression.
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Oncology
Dandan Li, Wenhao Zhao, Xinyu Zhang, Hanning Lv, Chunhong Li, Lichun Sun
Summary: Low NEFM expression/DNA methylation is associated with poor prognosis in breast cancer; NEFM expression positively correlates with macrophage infiltration; NEFM DNA methylation strongly negatively correlates with immune infiltration in BRCA.
CLINICAL EPIGENETICS
(2021)
Article
Oncology
Chuanxu Luo, Shuang Zhao, Cheng Peng, Chengshi Wang, Kejia Hu, Xiaorong Zhong, Ting Luo, Juan Huang, Donghao Lu
Summary: The study identified 15 mammographic radiomics features associated with breast cancer iDFS in the craniocaudal view but none in the mediolateral oblique view. Two lead features, S(1,-1)SumAverg and WavEnLL_s-6, were found to be associated with favorable and poor iDFS, respectively. These features were linked to eight pathways primarily involving cell cycle regulation in tumor tissues.
BRITISH JOURNAL OF CANCER
(2022)
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Oncology
Tao Jiang, Qian Chu, Huijuan Wang, Fei Zhou, Guanghui Gao, Xiaoxia Chen, Xuefei Li, Chao Zhao, Qinghua Xu, Wei Li, Fengying Wu, Anwen Xiong, Jing Zhao, Yaping Xu, Chunxia Su, Shengxiang Ren, Caicun Zhou, Fred R. Hirsch
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Oncology
Weina Li, Yu Deng, Qian Chu, Peng Zhang
Review
Immunology
Ni Zhang, Jingyao Tu, Xue Wang, Qian Chu
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Environmental Sciences
Li Yuan, Jinjin Cheng, Qian Chu, Xiu Ji, Jianjun Yuan, Fayun Feng, Ruichang Gao, Xiangyang Yu
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES
(2019)
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Oncology
Xiaoyun Zhou, Jiawei Shou, Jin Sheng, Chunwei Xu, Shengxiang Ren, Xiuyu Cai, Qian Chu, Wenxian Wang, Qinhong Zhen, Yuefen Zhou, Wenfeng Li, Hong Pan, Hongsen Li, Tao Sun, Huanqing Cheng, Huina Wang, Feng Lou, Chuangzhou Rao, Shanbo Cao, Hongming Pan, Yong Fang
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Oncology
Shengnan Yu, Jing Zhang, Yongxiang Yan, Xudong Yao, Lijuan Fang, Hui Xiong, Yang Liu, Qian Chu, Pengfei Zhou, Kongming Wu
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2019)
Review
Oncology
Anping Li, Ming Yi, Shuang Qin, Qian Chu, Suxia Luo, Kongming Wu
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2019)
Meeting Abstract
Oncology
Liu Huang, Vanisha Chummun, Qian Chu, Yuan Chen
ANNALS OF ONCOLOGY
(2019)
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Pharmacology & Pharmacy
Jingyao Tu, Kun Tu, Haoran Xu, Lei Wang, Xianglin Yuan, Xianya Qin, Li Kong, Qian Chu, Zhiping Zhang
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2020)
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Oncology
Jia-Tao Zhang, Ye Li, Li-Xu Yan, Zheng-Fei Zhu, Xiao-Rong Dong, Qian Chu, Lin Wu, Hong-Mei Zhang, Chun-Wei Xu, Gen Lin, Zong-Yang Yu, Jie Hu, Bo Zhu, Hui-Juan Wang, Fan Yang, Zheng-Bo Song, Zheng-Bo Han, Meng-Xia Li, Jie Lin, Yi-Long Wu, Jin-Liang Wang, Wen-Zhao Zhong
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Biotechnology & Applied Microbiology
Ming Yi, Tianye Li, Shuang Qin, Shengnan Yu, Qian Chu, Anping Li, Kongming Wu
BIOMED RESEARCH INTERNATIONAL
(2020)
Review
Oncology
Ming Yi, Bing Dong, Shuang Qin, Qian Chu, Kongming Wu, Suxia Luo
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2019)
Review
Oncology
Kongju Wu, Ming Yi, Shuang Qin, Qian Chu, Xinhua Zheng, Kongming Wu
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2019)
Review
Oncology
Ming Yi, Dechao Jiao, Shuang Qin, Qian Chu, Anping Li, Kongming Wu
INTEGRATIVE CANCER THERAPIES
(2019)
Article
Oncology
Xingsheng Hu, Dongyong Yang, Yalun Li, Li Li, Yan Wang, Peng Chen, Song Xu, Xingxiang Pu, Wei Zhu, Pengbo Deng, Junyi Yen, Hanhan Zhang, Analyn Lizaso, Hao Liu, Xinru Mao, Hai Huang, Qian Chu, Chengping Hu
CANCER BIOLOGY & MEDICINE
(2019)