Concomitant activation of GLI1 and Notch1 contributes to racial disparity of human triple negative breast cancer progression

A phase 1b study of the Notch inhibitor crenigacestat (LY3039478) in combination with other anticancer target agents (taladegib, LY3023414, or abemaciclib) in patients with advanced or metastatic solid tumors

(2021) Analia Azaro et al.   INVESTIGATIONAL NEW DRUGS

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Inhibition of Notch1 reverses EMT and chemoresistance to cisplatin via direct downregulation of MCAM in triple‐negative breast cancer cells

(2020) De Zeng et al.   INTERNATIONAL JOURNAL OF CANCER

Somatic mutations of triple-negative breast cancer: a comparison between Black and White women

(2020) Angela R. Omilian et al.   BREAST CANCER RESEARCH AND TREATMENT

Identification of Distinct Heterogenic Subtypes and Molecular Signatures Associated with African Ancestry in Triple Negative Breast Cancer Using Quantified Genetic Ancestry Models in Admixed Race Populations

(2020) Melissa Davis et al.   Cancers

NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation

(2020) Kai Miao et al.   Nature Communications

Practical classification of triple-negative breast cancer: intratumoral heterogeneity, mechanisms of drug resistance, and novel therapies

(2020) Antonio Marra et al.   npj Breast Cancer

Withaferin A inhibits lysosomal activity to block autophagic flux and induces apoptosis via energetic impairment in breast cancer cells

(2019) Nethaji Muniraj et al.   CARCINOGENESIS

The Hedgehog Signaling Pathway: A Viable Target in Breast Cancer?

(2019) Priyanka Bhateja et al.   Cancers

Breast cancer statistics, 2019

(2019) Carol E. DeSantis et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Involvement of hedgehog pathway in early onset, aggressive molecular subtypes and metastatic potential of breast cancer

(2018) Syeda Kiran Riaz et al.   Cell Communication and Signaling

Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets

(2018) Ádám Nagy et al.   Scientific Reports

First-in-human study of LY3039478, an oral Notch signaling inhibitor in advanced or metastatic cancer

(2018) C Massard et al.   ANNALS OF ONCOLOGY

Racial Disparity and Triple-Negative Breast Cancer in African-American Women: A Multifaceted Affair between Obesity, Biology, and Socioeconomic Determinants

(2018) Sumit Siddharth et al.   Cancers

Notch and its oncogenic activity in human malignancies

(2017) Marlena Brzozowa-Zasada et al.   European Surgery-Acta Chirurgica Austriaca

Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3

(2017) S Sengupta et al.   ONCOGENE

Myc mediates cancer stem-like cells and EMT changes in triple negative breast cancers cells

(2017) Shuping Yin et al.   PLoS One

Anti-cell growth and anti-cancer stem cell activities of the non-canonical hedgehog inhibitor GANT61 in triple-negative breast cancer cells

(2017) Yoshikazu Koike et al.   Breast Cancer

Differences in the mutational landscape of triple-negative breast cancer in African Americans and Caucasians

(2016) Foluso O. Ademuyiwa et al.   BREAST CANCER RESEARCH AND TREATMENT

Inhibition of Sonic Hedgehog Signaling Pathway by Thiazole Antibiotic Thiostrepton Attenuates the CD44+/CD24-Stem-Like Population and Sphere-Forming Capacity in Triple-Negative Breast Cancer

(2016) Na Yang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Indolo-pyrido-isoquinolin based alkaloid inhibits growth, invasion and migration of breast cancer cells via activation of p53-miR34a axis

(2016) Dimiter B. Avtanski et al.   Molecular Oncology

c-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through upregulation of Notch1 via activation of c-Jun

(2016) X Xie et al.   ONCOGENE

NOTCH1 is a poor prognostic factor for breast cancer and is associated with breast cancer stem cells

(2016) Ying Zhong et al.   OncoTargets and Therapy

Comparison of the Genomic Landscape Between Primary Breast Cancer in African American Versus White Women and the Association of Racial Differences With Tumor Recurrence

(2015) Tanya Keenan et al.   JOURNAL OF CLINICAL ONCOLOGY

Global phosphotyrosine survey in triple-negative breast cancer reveals activation of multiple tyrosine kinase signaling pathways

(2015) Xinyan Wu et al.   Oncotarget

Honokiol activates LKB1-miR-34a axis and antagonizes the oncogenic actions of leptin in breast cancer

(2015) Dimiter B. Avtanski et al.   Oncotarget

Notch signaling: switching an oncogene to a tumor suppressor

(2014) C. Lobry et al.   BLOOD

Honokiol inhibits epithelial-mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E-cadherin axis

(2014) Dimiter B. Avtanski et al.   Molecular Oncology

Preclinical and Clinical Studies of Gamma Secretase Inhibitors with Docetaxel on Human Breast Tumors

(2013) A. F. Schott et al.   CLINICAL CANCER RESEARCH

Molecular Phenotypes in Triple Negative Breast Cancer from African American Patients Suggest Targets for Therapy

(2013) Robert Lindner et al.   PLoS One

Differentially Expressed Transcripts and Dysregulated Signaling Pathways and Networks in African American Breast Cancer

(2013) Paul A. Stewart et al.   PLoS One

Suppression of Acquired Docetaxel Resistance in Prostate Cancer through Depletion of Notch- and Hedgehog-Dependent Tumor-Initiating Cells

(2012) Josep Domingo-Domenech et al.   CANCER CELL

Med1 plays a critical role in the development of tamoxifen resistance

(2012) Arumugam Nagalingam et al.   CARCINOGENESIS

Phase I Pharmacologic and Pharmacodynamic Study of the Gamma Secretase (Notch) Inhibitor MK-0752 in Adult Patients With Advanced Solid Tumors

(2012) Ian Krop et al.   JOURNAL OF CLINICAL ONCOLOGY

Therapeutic approaches to modulating Notch signaling: Current challenges and future prospects

(2012) Casper Groth et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Identification of differentially expressed genes in breast tumors from African American compared with Caucasian women

(2011) Lori A. Field et al.   CANCER

Gli1 promotes cell survival and is predictive of a poor outcome in ERα-negative breast cancer

(2009) Lusheng Xu et al.   BREAST CANCER RESEARCH AND TREATMENT

Expression of aldehyde dehydrogenase 1 (ALDH1) is associated with basal-like markers and features of aggressive tumours in African breast cancer

(2009) H Nalwoga et al.   BRITISH JOURNAL OF CANCER

Differences in the Tumor Microenvironment between African-American and European-American Breast Cancer Patients

(2009) Damali N. Martin et al.   PLoS One

Bidirectional Crosstalk between Leptin and Insulin-like Growth Factor-I Signaling Promotes Invasion and Migration of Breast Cancer Cells via Transactivation of Epidermal Growth Factor Receptor

(2008) N. K. Saxena et al.   CANCER RESEARCH