Article
Virology
Weijun He, Weixu Zhang, Huixin Yan, Hefeng Xu, Yuan Xie, Qizhong Wu, Chengmin Wang, Guoying Dong
Summary: H1N1 influenza viruses have exhibited high resistance to adamantanes, with mutant variants mainly appearing in North America and Europe, becoming circulating strains worldwide since 2009. The study found that 80.65% of human H1N1 influenza viruses and 74.61% of swine H1N1 influenza viruses exhibited adamantanes resistance, while the frequency was only 1.86% in avian H1N1 influenza viruses.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Virology
Weixu Zhang, Hefeng Xu, Shuxuan Guan, Chengmin Wang, Guoying Dong
Summary: This study analyzed the available NA protein sequences of H1N1 influenza viruses worldwide and found that 3.76% of H1N1 viruses currently harbor oseltamivir resistance, with the most common mutation being H274Y. Oseltamivir resistance is mainly found in humans, swine, and avian, and the resistance level peaked in 2007-2008 and quickly decreased in 2009. The study highlights the importance of globally monitoring oseltamivir resistance.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Danielle Thompson, Christiana Victoria Cismaru, Jean-Sebastien Rougier, Martin Schwemmle, Gert Zimmer
Summary: The proton channel activity of bat influenza A virus (IAV) M2 proteins was found to be low, indicating that they are unable to fully protect acid-sensitive HA protein from conformational changes. The primary sequences of bat IAV M2 proteins also differ significantly from conventional IAV M2 proteins, suggesting possible differences in their biological function. This study reveals the importance of the proton channel activity of bat IAV M2 proteins in virus replication.
JOURNAL OF VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Jeong-Hyun Nam, Erica Espano, Eun-Jung Song, Sang-Mu Shim, Woonsung Na, Seo-Hee Jeong, Jiyeon Kim, Jaebong Jang, Daesub Song, Jeong-Ki Kim
Summary: Surveillance of circulating avian influenza viruses in South Korea from 2009 to 2013 revealed predominantly low pathogenic strains among wild migratory birds, with no matches found for high pathogenicity strains. Regular surveillance studies are crucial to identify potential sources of influenza viruses that may threaten animal and human health.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Ki-Hye Kim, Zhuo Li, Noopur Bhatnagar, Jeeva Subbiah, Bo Ryoung Park, Chong Hyun Shin, Peter Pushko, Bao-Zhong Wang, Sang-Moo Kang
Summary: The study developed a universal influenza vaccine candidate that can provide broad cross protection against diverse influenza A and B viruses, and is effective in both young and aged mice.
Article
Biology
Pia Ryt-Hansen, Jesper Schak Krog, Solvej Ostergaard Breum, Charlotte Kristiane Hjulsager, Anders Gorm Pedersen, Ramona Trebbien, Lars Erik Larsen
Summary: This paper presents the results of swIAV surveillance in Danish swine from 2011 to 2018, revealing multiple different circulating genotypes of the virus, including novel reassortants with human seasonal IAV gene segments. The phylogenetic analysis showed genetic drift in antigenic sites of the hemagglutinin protein and identified a swine divergent cluster among the viruses studied.
Article
Immunology
C. Joaquin Caceres, Yanmei Hu, Stivalis Cardenas-Garcia, Xiangmeng Wu, Haozhou Tan, Silvia Carnaccini, L. Claire Gay, Ginger Geiger, Chunlong Ma, Qing-Yu Zhang, Daniela Rajao, Daniel R. Perez, Jun Wang
Summary: The development of a novel deuterium-containing M2-S31N inhibitor UAWJ280 showed broad-spectrum antiviral activity against various influenza A strains and exhibited synergistic effects when combined with oseltamivir in cell culture. In vivo studies on mice demonstrated favorable pharmacokinetic properties and efficacy in improving clinical signs and survival in lethal challenges with oseltamivir-sensitive and -resistant IAV strains.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Microbiology
Ki-Hye Kim, Zhuo Li, Noopur Bhatnagar, Jeeva Subbiah, Bo Ryoung Park, Chong Hyun Shin, Peter Pushko, Bao-Zhong Wang, Sang-Moo Kang
Summary: This study developed a virus-like particle that can induce immune responses against multiple subtypes of influenza viruses. The vaccination provided broad protection against different strains of influenza A and B viruses. The findings suggest the potential of developing a universal vaccine against influenza in both young and aged populations.
Review
Biochemistry & Molecular Biology
Sphamadla E. Mtambo, Daniel G. Amoako, Anou M. Somboro, Clement Agoni, Monsurat M. Lawal, Nelisiwe S. Gumede, Rene B. Khan, Hezekiel M. Kumalo
Summary: Influenza viruses (IVs) are known causative agents of respiratory infections and global pandemics in humans, primarily due to their high mutation rates and numerous genomic segments leading to antiviral resistance. Current therapeutic options include vaccines and small molecule inhibitors, but there is a need for continuous development of new anti-influenza therapies targeting the M2 channel and neuraminidase. Further research and development are necessary to design novel inhibitors capable of inhibiting resistant strains.
Article
Microbiology
Daniel H. Goldhill, Ada Yan, Rebecca Frise, Jie Zhou, Jennifer Shelley, Ana Gallego Cortes, Shahjahan Miah, Omolola Akinbami, Monica Galiano, Maria Zambon, Angie Lackenby, Wendy S. Barclay
Summary: In ferrets, the favipiravir-resistant virus can successfully infect and be transmitted through contact and respiratory droplet routes, but the resistance mutation may decrease over time. The fitness advantage of the PA P653L mutant may lead to the loss of the PB1 resistance mutation K229R in vivo due to reassortment with the wild-type virus.
Article
Virology
Qianshuo Liu, Haowen Zeng, Xinghui Wu, Xuelian Yang, Guiqin Wang
Summary: This study provides insights into the prevalence characteristics and hemagglutinin evolution of H7N9 avian influenza viruses through the generation of a global epidemic map, construction of a phylogenetic tree, prediction of glycosylation sites, and comparison of hemagglutinin selection pressure.
Article
Chemistry, Medicinal
Xun Lv, Pengfei Wang, Chenning Li, Shuihong Cheng, Yuhai Bi, Xuebing Li
Summary: The conjugation of cholesterol to ZNV shows improved antiviral efficacy and can effectively protect mice from influenza virus infection. This new treatment has the potential for sustained therapeutic effects and provides an effective strategy for improving the pharmacokinetics and efficacy of other small-molecule therapeutics.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Virology
Dongchang He, Xiyue Wang, Huiguang Wu, Xiaoquan Wang, Yayao Yan, Yang Li, Tiansong Zhan, Xiaoli Hao, Jiao Hu, Shunlin Hu, Xiaowen Liu, Chan Ding, Shuo Su, Min Gu, Xiufan Liu
Summary: Reassortment between H9N2 and H7N9 viruses is frequent, but the patterns of reassortment are not fully understood. H7N9 virus and its progeny frequently exchange internal genes with H9N2, but rarely with other AIV subtypes. The rates of intrasubtype reassortment were high in waves 2-3 and 5, with PB2 c05 and M c02 clusters being dominant in wave 5.
Article
Microbiology
Ti Liu, Yousong Peng, Julong Wu, Shangwen Lu, Yujie He, Xiyan Li, Lin Sun, Shaoxia Song, Shengyang Zhang, Zhong Li, Xianjun Wang, Shu Zhang, Mi Liu, Zengqiang Kou
Summary: This study reported the long-term surveillance of avian influenza viruses (AIVs) in live bird markets in 16 cities in Shandong province from 2013 to 2019. The predominant subtype was H9, and the newly sequenced H9N2 viruses were genetically similar. Several molecular markers associated with human adaptation, mammalian virulence, and drug resistance were identified.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Virology
Nutan Mytle, Sonja Leyrer, Jon R. Inglefield, Andrea M. Harris, Thomas E. Hickey, Jacob Minang, Hang Lu, Zhidong Ma, Hanne Andersen, Nathan D. Grubaugh, Tina Guina, Mario H. Skiadopoulos, Michael J. Lacy
Summary: Research demonstrates that utilizing combinations of conserved antigens of influenza A virus, such as NP and various forms of M2e, can generate broad immune protection in mice, reducing lung viral burden and weight loss.
Article
Biochemistry & Molecular Biology
Qing-Yang Zhao, Yong-Bo Peng, Xiao-Jing Luo, Xi Luo, Hao Xu, Ming-Yu Wei, Qiu-Ju Jiang, Wen-Er Li, Li-Qun Ma, Jin-Chao Xu, Xiao-Cao Liu, Dun-An Zang, Yu-San She, He Zhu, Jinhua Shen, Ping Zhao, Lu Xue, Meng-Fei Yu, Weiwei Chen, Ping Zhang, Xiangning Fu, Jingyu Chen, Xiaowei Nie, Chenyou Shen, Shu Chen, Shanshan Chen, Jingcao Chen, Sheng Hu, Chunbin Zou, Gangjian Qin, Ying Fang, Jiuping Ding, Guangju Ji, Yun-Min Zheng, Tengyao Song, Yong-Xiao Wang, Qing-Hua Liu
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2017)
Article
Thermodynamics
Ge Ji, Jiafeng Wu, Yaping Chen, Guangju Ji
INTERNATIONAL JOURNAL OF REFRIGERATION-REVUE INTERNATIONALE DU FROID
(2017)
Article
Cell & Tissue Engineering
Jianmin Zhao, Henghua Cao, Luyang Tian, Weibang Huo, Kui Zhai, Pei Wang, Guangju Ji, Yue Ma
STEM CELLS AND DEVELOPMENT
(2017)
Article
Materials Science, Multidisciplinary
Chuan Sun, Shu Wang, Guangju Ji, Haijun Wu, Fuping Huang, Jiaxing Lv
Article
Multidisciplinary Sciences
Xi Luo, Lu Xue, Hao Xu, Qing-Yang Zhao, Qian Wang, Yu-Shan She, Dun-An Zang, Jinhua Shen, Yong-Bo Peng, Ping Zhao, Meng-Fei Yu, Weiwei Chen, Li-Qun Ma, Shu Chen, Shanshan Chen, Xiangning Fu, Sheng Hu, Xiaowei Nie, Chenyou Shen, Chunbin Zou, Gangjian Qin, Jiapei Dai, Guangju Ji, Yunchao Su, Shen Hu, Jingyu Chen, Qing-Hua Liu
SCIENTIFIC REPORTS
(2018)
Letter
Cell Biology
Yuting Guo, Huiwen Wang, Yinglong Tang, Yue Wang, Mengqi Zhang, Zhiguang Yang, Eric Nyirimigabo, Bin Wei, Zhongbing Lu, Guangju Ji
Article
Biochemistry & Molecular Biology
Yang Liu, Huiwen Wang, Jun Wang, Bin Wei, Xinyi Zhang, Mengqi Zhang, Dong Cao, Jiang Dai, Zhen Wang, Eric Nyirimigabo, Guangju Ji
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2019)
Article
Cell Biology
Xiuyun Sun, Jun Wang, Xia Yao, Wen Zheng, Yang Mao, Tianlong Lan, Liguo Wang, Yonghui Sun, Xinyi Zhang, Qiuye Zao, Jianguo Zhao, Rui-Ping Xiao, Xiuqin Zhang, Guangju Ji, Yu Rao
Article
Biochemistry & Molecular Biology
Eric Nyirimigabo, Meng Jin, Zhiguang Yang, Jun Wang, Kui Zhai, Yang Mao, Huiwen Wang, Guangju Ji
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2019)
Article
Materials Science, Multidisciplinary
Jiuye Chen, Wei Sun, Ning Liu, Qidong Wang, Yulong Wang, Guangju Ji, Fengyi Ke, Ding Ma, Huining Zhao
Article
Cell & Tissue Engineering
Junling Gao, Juntao Yuan, Qun Liu, Yuanli Wang, Huiwen Wang, Yingjie Chen, Wenjun Ding, Guangju Ji, Zhongbing Lu
Summary: The research found that ADSCs can protect against the adverse health effects of PM2.5 exposure by attenuating pulmonary inflammation and cell death. This suggests that ADSC transplantation may be a potential therapeutic approach for severe air pollution-associated diseases.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Genetics & Heredity
Youkun Bi, Lei Gu, Jun Wang, Yan Chang, Meng Jin, Yang Mao, Huiwen Wang, Guangju Ji
Summary: The AdBlue system, utilizing an enzymatic assembly strategy, significantly reduces the time and labor required for constructing recombinant adenoviruses, simplifies the preparation of adenoviruses carrying nuclease complexes for CRISPR/Cas9 design, and induces high levels of site-specific mutagenesis.
Article
Cell Biology
Youkun Bi, Zhiguang Yang, Meng Jin, Kui Zhai, Jun Wang, Yang Mao, Yang Liu, Mingqin Ding, Huiwen Wang, Fengchao Wang, Hong Cai, Guangju Ji
Summary: This study demonstrates that the ERp44 gene plays a crucial role in the formation of endocardial cushions during heart development. It affects the development of the endocardial cushion by influencing VEGFA-mediated endocardial-mesenchymal transition.
CELL PROLIFERATION
(2022)
Article
Cell & Tissue Engineering
Youkun Bi, Xuejun Guo, Mengqi Zhang, Keqi Zhu, Chentao Shi, Baoqi Fan, Yanyun Wu, Zhiguang Yang, Guangju Ji
Summary: The study found that promoting mitochondrial transfer via stem cell transplantation can effectively treat NAFLD and related metabolic diseases by restoring dysfunctional mitochondria and reducing fat accumulation.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Lei Gu, Huiwen Wang, Jun Wang, Yuting Guo, Yinglong Tang, Yang Mao, Lijuan Chen, Hua Lou, Guangju Ji
ANTIOXIDANTS & REDOX SIGNALING
(2017)