The “Genomic Storm” Induced by Bacterial Endotoxin Is Calmed by a Nuclear Transport Modifier That Attenuates Localized and Systemic Inflammation

Cytokine and Nitric Oxide Levels in Patients with Sepsis – Temporal Evolvement and Relation to Platelet Mitochondrial Respiratory Function

(2014) Fredrik Sjövall et al.   PLoS One

Genomic responses in mouse models greatly mimic human inflammatory diseases

(2014) Keizo Takao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Severe Sepsis and Septic Shock

(2013) Derek C. Angus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Nuclear Import Shuttles, Importins/Karyopherins alpha by a Peptide Mimicking the NFκB1/p50 Nuclear Localization Sequence

(2013) Jozef Zienkiewicz et al.   Journal of the American Heart Association

Host Response Signature to Staphylococcus aureus Alpha-Hemolysin Implicates Pulmonary Th17 Response

(2012) Karen M. Frank et al.   INFECTION AND IMMUNITY

The acute respiratory distress syndrome

(2012) Michael A. Matthay et al.   JOURNAL OF CLINICAL INVESTIGATION

Elevated Serum Interleukin-10 at Time of Hospital Admission Is Predictive of Mortality in Patients With Staphylococcus aureus Bacteremia

(2012) Warren E. Rose et al.   JOURNAL OF INFECTIOUS DISEASES

Lethality in a Murine Model of Pulmonary Anthrax is Reduced by Combining Nuclear Transport Modifier with Antimicrobial Therapy

(2012) Ruth Ann Veach et al.   PLoS One

Regulation of triglyceride metabolism by glucocorticoid receptor

(2012) Jen-Chywan Wang et al.   Cell and Bioscience

A combined score of pro- and anti-inflammatory interleukins improves mortality prediction in severe sepsis

(2011) David Andaluz-Ojeda et al.   CYTOKINE

A genomic storm in critically injured humans

(2011) Wenzhong Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

New perspectives on immunomodulatory therapy for bacteraemia and sepsis

(2010) Steven M. Opal   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Metabolic response to endotoxin in vivo in the conscious mouse: role of interleukin-6

(2010) Andrea Tweedell et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Hospital-Acquired Infections Due to Gram-Negative Bacteria

(2010) Anton Y. Peleg et al.   NEW ENGLAND JOURNAL OF MEDICINE

In Vivo Islet Protection by a Nuclear Import Inhibitor in a Mouse Model of Type 1 Diabetes

(2010) Daniel J. Moore et al.   PLoS One

Modulation of nuclear factor-kappaB improves cardiac dysfunction associated with cardiopulmonary bypass and deep hypothermic circulatory arrest*

(2009) Jodie Y. Duffy et al.   CRITICAL CARE MEDICINE

International Study of the Prevalence and Outcomes of Infection in Intensive Care Units

(2009) Jean-Louis Vincent   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Suppression of Acute Lung Inflammation by Intracellular Peptide Delivery of a Nuclear Import Inhibitor

(2009) Danya Liu et al.   MOLECULAR THERAPY

TLRs and innate immunity

(2008) B. A. Beutler   BLOOD

The Glucocorticoid Receptor Controls Hepatic Dyslipidemia through Hes1

(2008) Ulrike Lemke et al.   Cell Metabolism

NF-κB and P38 MAPK Inhibition Improve Survival in Endotoxin Shock and in a Cecal Ligation and Puncture Model of Sepsis in Combination With Antibiotic Therapy

(2008) Adrian W. O'Sullivan et al.   JOURNAL OF SURGICAL RESEARCH

Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement

(2008) Ian Chopra et al.   LANCET INFECTIOUS DISEASES

Hydrocortisone Therapy for Patients with Septic Shock

(2008) Charles L. Sprung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL