Article
Medicine, General & Internal
John P. Bonnewell, Matthew P. Rubach, Deng B. Madut, Manuela Carugati, Michael J. Maze, Kajiru G. Kilonzo, Furaha Lyamuya, Annette Marandu, Nathaniel H. Kalengo, Bingileki F. Lwezaula, Blandina T. Mmbaga, Venance P. Maro, John A. Crump
Summary: This study evaluated the performance of the Universal Vital Assessment (UVA) score compared to other illness severity scores in predicting in-hospital mortality among adults with febrile illness in northern Tanzania. The UVA score performed favorably compared to other scores, showing potential utility in triage and prognosis of patients in low- to middle-income settings like sub-Saharan Africa.
Article
Infectious Diseases
Manuel Ponce-Alonso, Borja M. Fernandez-Felix, Ana Halperin, Mario Rodriguez-Dominguez, Ana M. Sanchez-Diaz, Rafael Canton, Alfonso Muriel, Javier Zamora, Rosa del Campo
Summary: In this study, it was found that male patients admitted to the ICU with septic bacteremia were more likely to have sepsis and higher mortality rates. Although males presented with worse clinical characteristics upon ICU admission, gender did not have a significant influence on mortality.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, Research & Experimental
Jie Weng, Ruonan Hou, Xiaoming Zhou, Zhe Xu, Zhiliang Zhou, Peng Wang, Liang Wang, Chan Chen, Jinyu Wu, Zhiyi Wang
Summary: The study developed and validated a mortality prediction score (POSMI) for septic patients in ICU, which showed good calibration and discrimination in the development cohort and three validation cohorts, and demonstrated higher net benefit in decision curve analysis compared to other scoring systems.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Fernando Sanchez-Moran, Maria Lidon Mateu-Campos, Francisco Bernal-Julian, Ali Gil-Santana, Angeles Sanchez-Herrero, Teresa Martinez-Gaspar
Summary: In recent years, there have been multiple efforts to identify targets and therapeutic measures in the host response to infection. Haemoadsorption, with the potential of modulating inflammatory response through the adsorption of soluble inflammatory mediators, could be used as an adjuvant therapy in septic patients. The recent COVID-19 pandemic has renewed interest in this therapy.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Pediatrics
Noa Fleiss, Richard A. Polin
Summary: Organ dysfunction severity scores (SOFA) are commonly used in assessing risk of mortality from sepsis in adults and children, but there is no definitive definition and criteria for neonatal sepsis. Recent studies have focused on the clinical progression and mortality of neonatal sepsis and developed a neonatal SOFA (nSOFA) score based on observed patterns of organ dysfunction.
CURRENT OPINION IN PEDIATRICS
(2023)
Article
Medicine, General & Internal
Noa Fleiss, Sarah A. Coggins, Angela N. Lewis, Angela Zeigler, Krista E. Cooksey, L. Anne Walker, Ameena N. Husain, Brenda S. de Jong, Aaron Wallman-Stokes, Wael Alrifai, Douwe H. Visser, Misty Good, Brynne Sullivan, Richard A. Polin, Camilia R. Martin, James L. Wynn
Summary: Through a multicenter retrospective cohort study at 7 academic neonatal intensive care units, it was found that the nSOFA score was associated with late-onset infection mortality in preterm infants, suggesting it may serve as the foundation for a consensus definition of sepsis in this population.
Article
Immunology
Cheng-Long Ge, Li-Na Zhang, Yu-Hang Ai, Wei Chen, Zhi-Wen Ye, Yu Zou, Qian-Yi Peng
Summary: This study aimed to evaluate the association between b-blocker therapy and mortality in patients with sepsis. The findings showed that long-acting b-blockers were associated with improved 28- and 90-day mortality in patients with sepsis, while short-acting b-blockers did not reduce mortality in sepsis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
I. Wayan Suranadi, Cynthia Dewi Sinardja, Iwan Antara Suryadi
Summary: The study assessed the prognostic utility of procalcitonin (PCT) in high-risk sepsis patients and found that PCT levels were associated with mortality and SOFA scores. Further research is needed to provide more evidence to help reduce the mortality and morbidity of sepsis.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Gennaro De Pascale, Salvatore Lucio Cutuli, Simone Carelli, Rikardo Xhemalaj, Tommaso Rosa, Giuseppe Bello, Joel Vargas, Melania Cesarano, Luca Montini, Eloisa Sofia Tanzarella, Gabriele Pintaudi, Mariangela Di Muro, Domenico Luca Grieco, Massimo Antonelli
Summary: This study investigated the clinical efficacy and safety of concomitant administration of Remdesivir and Dexamethasone (Rem-Dexa) in COVID-19 critically ill patients receiving high flow oxygen therapy (HFOT) or non-invasive ventilation (NIV). The results showed that the 28-day intubation rate was lower in patients who received Rem-Dexa, but the end-of-treatment clinical improvement was larger in this group.
Article
Medical Laboratory Technology
Chun-Mei Huang, Xin-Jie Xu, Wen-Qi Qi, Qin-Min Ge
Summary: This study found that increased levels of sCD25 were independently associated with poor clinical outcomes in sepsis patients, and sCD25 levels were positively correlated with disease severity. Further research is needed to improve the understanding of the pathophysiology of this relationship.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Multidisciplinary Sciences
Si Xu Liu, Sheng Qin Yu, Kai Jing Yang, Ji Yi Liu, Fan Yang, Ye Li, Chang Li Yao, Guang Sheng Zhao, Feng Zhi Sun
Summary: This study aimed to establish a prediction model for coronary heart disease (CHD) by combining cardiopulmonary exercise test (CPET) indexes and comparing the clinical effectiveness with other models. The prediction model showed good accuracy in distinguishing and calibrating CHD cases, and performed slightly better than other reference models.
SCIENTIFIC REPORTS
(2023)
Article
Critical Care Medicine
Hong Yeul Lee, Jinwoo Lee, Yoon Sun Jung, Woon Yong Kwon, Dong Kyu Oh, Mi Hyeon Park, Chae-Man Lim, Sang-Min Lee
Summary: This study aims to determine the association between preexisting clinical frailty and clinical outcomes in patients with sepsis. The results showed that preexisting clinical frailty is associated with worse clinical outcomes in patients with sepsis, including inhospital mortality and discharge to home.
CRITICAL CARE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Kristina Boss, Michael Jahn, Daniel Wendt, Zaki Haidari, Ender Demircioglu, Matthias Thielmann, Arjang Ruhparwar, Andreas Kribben, Bartosz Tyczynski
Summary: Extracorporeal cytokine adsorption significantly reduces the need for inotropes in patients with septic shock and acute kidney injury after cardiac surgery. It also lowers the observed in-hospital mortality rate compared to the predicted rates based on SOFA and APACHE II scores.
Article
Biochemistry & Molecular Biology
Jaume Baldira, Juan Carlos Ruiz-Rodriguez, Adolfo Ruiz-Sanmartin, Luis Chiscano, Alejandro Cortes, Diego angeles Sistac, Roser Ferrer-Costa, Inma Comas, Yolanda Villena, Maria Nieves Larrosa, Juan Jose Gonzalez-Lopez, Ricard Ferrer
Summary: Early diagnosis and appropriate treatments are crucial in reducing mortality risk for septic patients. Existing biomarkers may not be sufficient in predicting severe organ dysfunction or elevated mortality risk. This study evaluated the predictive value of MR-proADM, PCT, CRP, and lactate for 28-day mortality in sepsis patients and those with a SOFA score =6, showing that lactate had the highest predictive ability.
Article
Critical Care Medicine
Sean R. Townsend, Gary S. Phillips, Reena Duseja, Lemeneh Tefera, Derek Cruikshank, Robert Dickerson, H. Bryant Nguyen, Christa A. Schorr, Mitchell M. Levy, R. Phillip Dellinger, William A. Conway, Warren S. Browner, Emanuel P. Rivers
Summary: This study examined the association between compliance with the SEP-1 quality measure and 30-day mortality among Medicare beneficiaries. The results showed that compliance with SEP-1 was associated with lower 30-day mortality.
Article
Microbiology
Daniel Sepulveda-Crespo, Ana Trevino-Nakoura, Jose M. Bellon, Maria A. Jimenez-Sousa, Pablo Ryan, Isidoro Martinez, Amanda Fernandez-Rodriguez, Salvador Resino
Summary: The standard algorithm for diagnosing hepatitis C virus (HCV) infection involves an HCV antibody test for screening and a nucleic acid amplification test (NAAT) for confirmation. The accuracy of the Abbott ARCHITECT HCV Ag assay was evaluated in people living with HIV/AIDS (PLWHA), showing good performance in high-prevalence settings but poor in low-prevalence settings. It was excellent in excluding active HCV infection.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Virology
Ana Virseda-Berdices, Leyre Concostrina-Martinez, Oscar Martinez-Gonzalez, Rafael Blancas, Salvador Resino, Pablo Ryan, Maria Martin-Vicente, Oscar Brochado-Kith, Natalia Blanca-Lopez, Maria J. Mallol Poyato, Blanca Lopez Matamala, Carmen Martin Parra, Maria A. Jimenez-Sousa, Amanda Fernandez-Rodriguez
Summary: Increasing age is associated with severity and higher mortality of COVID-19. Telomere shortening is associated with higher risk of infections and may be used to identify those patients who are more likely to die. This study evaluated the association between relative telomere length (RTL) and COVID-19 mortality. Lower RTL was associated with a higher risk of death in women at 30 and 90 days.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, Research & Experimental
Sergio Salguero, Oscar Brochado-Kith, Ana Virseda Verdices, Juan Berenguer, Juan Gonzalez-Garcia, Isidoro Martinez, Cristina Diez, Victor Hontanon, Leire Perez-Latorre, Amanda Fernandez-Rodriguez, Maria Angeles Jimenez-Sousa, Salvador Resino
Summary: We identified a gene expression signature associated with advanced cirrhosis with high risk for clinically significant portal hypertension (CSPH) in HIV/HCV coinfected patients through analyzing the gene expression profile of peripheral blood mononuclear cells (PBMCs). A cross-sectional study on 68 patients was conducted, and liver stiffness measurement (LSM) was used for stratification. We found 60 differentially expressed transcripts between patients with LSM < 12.5 kPa and >= 25 kPa, and two of them were validated in a different cohort.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Editorial Material
Medicine, General & Internal
Amanda de la Fuente, Nadia Garcia-Mateo, Jesus F. Bermejo-Martin
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Public, Environmental & Occupational Health
R. Lopez-Herrero, L. Sanchez-de Prada, A. Tamayo-Velasco, M. Lorenzo-Lopez, E. Gomez-Pesquera, B. Sanchez-Quiros, O. de la Varga-Martinez, E. Gomez-Sanchez, S. Resino, E. Tamayo, A. Alvaro-Meca
Summary: In this study, we examined the bacterial co-infections in COVID-19 hospitalized patients in Spain in 2020. The incidence of bacterial co-infection was found to be 2.3%, and the main risk factors were organ failure, obesity, and male sex. Co-infection was associated with worse outcomes, including higher mortality rates and longer hospital stays.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Virology
Daniel Sepulveda-Crespo, Maria A. Jimenez-Sousa, Amanda Fernandez-Rodiguez, Maria A. Munoz-Fernandez, Jose Luis Jimenez, Santiago Moreno, Felipe Garcia, Isidoro Martinez, Jose M. Benito, Norma Rallon, Salvador Resino
Summary: In this retrospective cohort study, we found a significant association between IRF5-TNPO3 polymorphisms and HIV elite control in long-term nonprogressors (LTNPs). Specifically, certain genotypes and the favorable haplotype of IRF5-TNPO3 were associated with HIV elite control.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Erola Pairo-Castineira, Konrad Rawlik, Andrew D. Bretherick, Ting Qi, Yang Wu, Isar Nassiri, Glenn A. McConkey, Marie Zechner, Lucija Klaric, Fiona Griffiths, Wilna Oosthuyzen, Athanasios Kousathanas, Anne Richmond, Jonathan Millar, Clark D. Russell, Tomas Malinauskas, Ryan Thwaites, Kirstie Morrice, Sean Keating, David Maslove, Alistair Nichol, Malcolm G. Semple, Julian Knight, Manu Shankar-Hari, Charlotte Summers, Charles Hinds, Peter Horby, Lowell Ling, Danny McAuley, Hugh Montgomery, Peter J. M. Openshaw, Colin Begg, Timothy Walsh, Albert Tenesa, Carlos Flores, Jose A. Riancho, Augusto Rojas-Martinez, Pablo Lapunzina, Jian Yang, Chris P. Ponting, James F. Wilson, Veronique Vitart, Malak Abedalthagafi, Andre D. Luchessi, Esteban J. Parra, Raquel Cruz, Angel Carracedo, Angie Fawkes, Lee Murphy, Kathy Rowan, Alexandre C. Pereira, Andy Law, Benjamin Fairfax, Sara Clohisey Hendry, J. Kenneth Baillie
Summary: This study analyzed genetic data from 24,202 severe COVID-19 cases and identified potentially druggable targets, including inflammatory signaling, monocyte-macrophage activation and endothelial permeability, immunometabolism, and host factors required for viral entry and replication.
Review
Virology
Daniel Sepulveda-Crespo, Ana Trevino-Nakoura, Jose M. Bellon, Amanda Fernandez-Rodriguez, Pablo Ryan, Isidoro Martinez, Maria A. Jimenez-Sousa, Salvador Resino
Summary: This meta-analysis evaluated the diagnostic performance of the Abbott ARCHITECT HCV Ag assay for diagnosing active hepatitis C. The assay showed excellent sensitivity, specificity, and accuracy. However, its diagnostic utility may be limited in low prevalence settings, and further confirmation is recommended.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Infectious Diseases
Jesus F. Bermejo-Martin, Nadia Garcia-Mateo, Anna Motos, Salvador Resino, Luis Tamayo, Pablo Ryan Murua, Elena Bustamante-Munguira, Elena Gallego Curto, Alejandro Ubeda-Iglesias, Maria del Carmen de la Torre, Angel Estella, Sandra Campos-Fernandez, Ignacio Martinez Varela, Felipe Perez-Garcia, Lorenzo Socias, Juan Lopez Messa, Pablo Vidal-Cortes, Victor Sagredo Meneses, Milagros Gonzalez-Rivera, Nieves Carbonell, David de Gonzalo-Calvo, Maria Cruz Martin Delgado, Luis Jorge Valdivia, Caridad Martin-Lopez, Ruth Noemi Jorge Garcia, Emilio Maseda, Ana Loza-Vazquez, David J. Kelvin, Ferran Barbe, Antoni Torres, CIBERES UCI COVID Grp
Summary: This study evaluates the association between viral RNA load in plasma and host response, complications, and deaths in critically ill patients with COVID-19. The presence of a so-called viral storm is associated with increased all-cause death in patients admitted to the intensive care unit with severe COVID-19.
Correction
Medicine, Research & Experimental
Sergio Salguero, Oscar Brochado-Kith, Ana Virseda Verdices, Juan Berenguer, Juan Gonzalez-Garcia, Isidoro Martinez, Cristina Diez, Victor Hontanon, Leire Perez-Latorre, Amanda Fernandez-Rodriguez, Maria Angeles Jimenez-Sousa, Salvador Resino
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Ruben Martin-Escolano, Ana Virseda-Berdices, Juan Berenguer, Juan Gonzalez-Garcia, Oscar Brochado-Kith, Amanda Fernandez-Rodriguez, Cristina Diez, Victor Hontanon, Salvador Resino, Maria Angeles Jimenez-Sousa
Summary: This study aimed to evaluate the association between plasma immune checkpoint proteins at baseline with hepatic steatosis index increase at the end of follow-up in HIV/HCV-coinfected patients. The results showed that higher levels of immune checkpoint proteins BTLA, CD137, CD80, GITR, LAG-3, and PD-L1 before HCV therapy were associated with a long-term increase in hepatic steatosis index after successful HCV therapy, suggesting a potential predictive role for early detection of progression towards steatosis in HIV/HCV-coinfected patients.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Environmental Sciences
Laura Sanchez-de Prada, Jose María Eiros-Bachiller, Alvaro Tamayo-Velasco, Marta Martin-Fernandez, F. Javier Alvarez, Carlos Giner-Baixauli, Eduardo Tamayo, Salvador Resino, Alejandro Alvaro-Meca
Summary: This study investigated the relationship between short-term exposure to environmental factors and COVID-19 outcomes in Spain during the lockdown and post-lockdown period. The results showed that PM2.5 had the strongest association with hospital admissions and mortality, followed by PM10, NO2, and SO2. ICU admissions were also associated with these pollutants. PM2.5 and PM10 were the most critical factors related to ICU mortality.
ENVIRONMENTAL RESEARCH
(2023)
Article
Infectious Diseases
Maria Martin-Vicente, Hloni Mthiyane, Maria A. Jimenez-Sousa, Kathleen Subramoney, Orienka Hellferscee, Nicole Wolter, Sibongile Walaza, Amanda Fernandez-Rodriguez, Cheryl Cohen, Anne von Gottberg, Salvador Resino, Isidoro Martinez, Florette K. Treurnicht
Summary: The TNIP1 gene polymorphisms are associated with the susceptibility to symptomatic HRSV infection and bronchiolitis in infants, particularly the rs73272842 G allele and rs999011 C allele.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Cell Biology
Patricia Castro-Santos, Augusto Rojas-Martinez, Jose A. Riancho, Pablo Lapunzina, Carlos Flores, Angel Carracedo, Roberto Diaz-Pena, Scourge Cohort Group
Summary: We investigated the relationship between HLA polymorphisms and susceptibility to SARS-CoV-2 infection and disease severity. Genotyping data from 9373 COVID-19-positive cases and 5943 population controls were analyzed. The study found associations between HLA-B*14:02 and HLA-C*08:02 alleles with a lower risk of COVID-19 infection, and HLA-A*11:01 and HLA-C*04:01 alleles with disease severity.
Article
Biochemistry & Molecular Biology
Erick Joan Vidal-Alcantara, Vicente Mas, Maria Belen Yelamos, Julian Gomez, Rafael Amigot-Sanchez, Salvador Resino, Isidoro Martinez
Summary: The study aimed to produce murine monoclonal antibodies against HCVcAg for the rapid and inexpensive detection of HCV infection. Four specific monoclonal antibodies were obtained, with three of them being able to recognize HCVcAg from all genotypes tested. These antibodies showed stable binding properties and can be used for detecting HCVcAg in HCV-infected samples.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.