Mass cytometry as a platform for the discovery of cellular biomarkers to guide effective rheumatic disease therapy

Multiplexed ion beam imaging of human breast tumors

(2014) Michael Angelo et al.   NATURE MEDICINE

Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry

(2014) Charlotte Giesen et al.   NATURE METHODS

Pathogenesis and prevention of rheumatic disease: focus on preclinical RA and SLE

(2014) Kevin D. Deane et al.   Nature Reviews Rheumatology

Automated identification of stratifying signatures in cellular subpopulations

(2014) Robert V. Bruggner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics

(2014) Glynn Dennis et al.   ARTHRITIS RESEARCH & THERAPY

ACPA-positive and ACPA-negative rheumatoid arthritis differ in their requirements for combination DMARDs and corticosteroids: secondary analysis of a randomized controlled trial

(2014) Seth D Seegobin et al.   ARTHRITIS RESEARCH & THERAPY

Tissue factor expression in rheumatoid synovium: a potential role in pannus invasion of rheumatoid arthritis

(2013) Lujun Chen et al.   ACTA HISTOCHEMICA

Single-cell mass cytometry for analysis of immune system functional states

(2013) Zach B Bjornson et al.   CURRENT OPINION IN IMMUNOLOGY

Combinatorial tetramer staining and mass cytometry analysis facilitate T-cell epitope mapping and characterization

(2013) Evan W Newell et al.   NATURE BIOTECHNOLOGY

viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia

(2013) El-ad David Amir et al.   NATURE BIOTECHNOLOGY

Critical assessment of automated flow cytometry data analysis techniques

(2013) Nima Aghaeepour et al.   NATURE METHODS

Mechanistic biomarkers for clinical decision making in rheumatic diseases

(2013) William H. Robinson et al.   Nature Reviews Rheumatology

Automatic Classification of Cellular Expression by Nonlinear Stochastic Embedding (ACCENSE)

(2013) K. Shekhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytokine-producing B cells as regulators of pathogenic and protective immune responses

(2012) Simon Fillatreau   ANNALS OF THE RHEUMATIC DISEASES

CytoSPADE: high-performance analysis and visualization of high-dimensional cytometry data

(2012) M. D. Linderman et al.   BIOINFORMATICS

A platinum-based covalent viability reagent for single-cell mass cytometry

(2012) Harris G. Fienberg et al.   CYTOMETRY PART A

Cytometry by Time-of-Flight Shows Combinatorial Cytokine Expression and Virus-Specific Cell Niches within a Continuum of CD8+ T Cell Phenotypes

(2012) Evan W. Newell et al.   IMMUNITY

From single cells to deep phenotypes in cancer

(2012) Sean C Bendall et al.   NATURE BIOTECHNOLOGY

Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators

(2012) Bernd Bodenmiller et al.   NATURE BIOTECHNOLOGY

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

(2012) Steve Eyre et al.   NATURE GENETICS

A deep profiler's guide to cytometry

(2012) Sean C. Bendall et al.   TRENDS IN IMMUNOLOGY

The role of RANK ligand/osteoprotegerin in rheumatoid arthritis

(2012) Piet Geusens   Therapeutic Advances in Musculoskeletal Disease

Review of treatment response in rheumatoid arthritis: assessment of heterogeneity

(2011) Iris Goetz et al.   CURRENT MEDICAL RESEARCH AND OPINION

Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE

(2011) Peng Qiu et al.   NATURE BIOTECHNOLOGY

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

(2011) S. C. Bendall et al.   SCIENCE

The number of elevated cytokines and chemokines in preclinical seropositive rheumatoid arthritis predicts time to diagnosis in an age-dependent manner

(2010) Kevin D. Deane et al.   ARTHRITIS AND RHEUMATISM

Steady-state generation of mucosal IgA+ plasmablasts is not abrogated by B-cell depletion therapy with rituximab

(2010) H. E. Mei et al.   BLOOD

MicroRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patients

(2010) Takuya Niimoto et al.   BMC MUSCULOSKELETAL DISORDERS

Redox signalling and the inflammatory response in rheumatoid arthritis

(2010) L. I. Filippin et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

B cells in the pathogenesis and treatment of rheumatoid arthritis

(2010) Bethany Marston et al.   CURRENT OPINION IN RHEUMATOLOGY

The vasculature in rheumatoid arthritis: cause or consequence?

(2010) Ewa M. Paleolog   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Leveraging Human Genetics to Develop Future Therapeutic Strategies in Rheumatoid Arthritis

(2010) Robert M. Plenge et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Biomarkers for rheumatoid arthritis: Making it personal

(2010) Tamsin M. Lindstrom et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Mass Cytometry: Technique for Real Time Single Cell Multitarget Immunoassay Based on Inductively Coupled Plasma Time-of-Flight Mass Spectrometry

(2009) Dmitry R. Bandura et al.   ANALYTICAL CHEMISTRY

CD11c as a Transcriptional Biomarker to Predict Response to Anti-TNF Monotherapy With Adalimumab in Patients With Rheumatoid Arthritis

(2009) B Stuhlmüller et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Immunopathogenesis of Rheumatoid Arthritis

(2008) John B. Imboden   Annual Review of Pathology-Mechanisms of Disease

Sialic acid-binding Ig-like lectin 1 expression in inflammatory and resident monocytes is a potential biomarker for monitoring disease activity and success of therapy in systemic lupus erythematosus

(2008) Robert Biesen et al.   ARTHRITIS AND RHEUMATISM

Expansion of a unique macrophage subset in rheumatoid arthritis synovial lining layer

(2008) M. Tanaka et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY