A Comparison of Protein Kinases Inhibitor Screening Methods Using Both Enzymatic Activity and Binding Affinity Determination

A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery

(2013) Yinghong Gao et al.   BIOCHEMICAL JOURNAL

What general conclusions can we draw from kinase profiling data sets?

(2013) Jeffrey J. Sutherland et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The Evolution of Protein Kinase Inhibitors from Antagonists to Agonists of Cellular Signaling

(2011) Arvin C. Dar et al.   Annual Review of Biochemistry

Interrogating the kinome

(2011) Chao Zhang et al.   NATURE BIOTECHNOLOGY

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

(2011) Theonie Anastassiadis et al.   NATURE BIOTECHNOLOGY

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

Navigating the kinome

(2011) James T Metz et al.   Nature Chemical Biology

Trends in Kinase Selectivity: Insights for Target Class-Focused Library Screening

(2010) Shana L. Posy et al.   JOURNAL OF MEDICINAL CHEMISTRY

SH2 domains: modulators of nonreceptor tyrosine kinase activity

(2009) Panagis Filippakopoulos et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Protein kinase inhibitors: contributions from structure to clinical compounds

(2009) Louise N. Johnson   QUARTERLY REVIEWS OF BIOPHYSICS

Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation

(2008) Panagis Filippakopoulos et al.   CELL

Therapeutic Protein Kinase Inhibitors

(2008) S. K. Grant   CELLULAR AND MOLECULAR LIFE SCIENCES

The challenge of selecting protein kinase assays for lead discovery optimization

(2008) Haiching Ma et al.   Expert Opinion on Drug Discovery

Assessment of Chemical Coverage of Kinome Space and Its Implications for Kinase Drug Discovery

(2008) Paul Bamborough et al.   JOURNAL OF MEDICINAL CHEMISTRY

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

High-throughput kinase profiling as a platform for drug discovery

(2008) David M. Goldstein et al.   NATURE REVIEWS DRUG DISCOVERY