Gene Expression Profiling Identifies Microphthalmia-Associated Transcription Factor (MITF) and Dickkopf-1 (DKK1) as Regulators of Microenvironment-Driven Alterations in Melanoma Phenotype

Natural Compounds' Activity against Cancer Stem-Like or Fast-Cycling Melanoma Cells

(2014) Malgorzata Sztiller-Sikorska et al.   PLoS One

Parthenolide enhances dacarbazine activity against melanoma cells

(2013) Kamila Koprowska et al.   ANTI-CANCER DRUGS

Parthenolide reduces the frequency of ABCB5-positive cells and clonogenic capacity of melanoma cells from anchorage independent melanospheres

(2013) Malgorzata Czyz et al.   CANCER BIOLOGY & THERAPY

Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF

(2013) Rizwan Haq et al.   CANCER CELL

PRDM1 is directly targeted by miR-30a-5p and modulates the Wnt/β-catenin pathway in a Dkk1-dependent manner during glioma growth

(2013) Xuan Wang et al.   CANCER LETTERS

Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis

(2013) Y. Zhang et al.   CANCER RESEARCH

Chromatin Regulator PRC2 Is a Key Regulator of Epigenetic Plasticity in Glioblastoma

(2013) A. Natsume et al.   CANCER RESEARCH

HMGA2 Is a Driver of Tumor Metastasis

(2013) A. Morishita et al.   CANCER RESEARCH

Mek inhibition results in marked antitumor activity against metastatic melanoma patient-derived melanospheres and in melanosphere-generated xenografts

(2013) Giovanni Sette et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

In Vitro Analysis of Breast Cancer Cell Line Tumourspheres and Primary Human Breast Epithelia Mammospheres Demonstrates Inter- and Intrasphere Heterogeneity

(2013) Chanel E. Smart et al.   PLoS One

CD49fhigh Cells Retain Sphere-Forming and Tumor-Initiating Activities in Human Gastric Tumors

(2013) Hiroshi Fukamachi et al.   PLoS One

Therapeutic Targeting of Tumor Growth and Angiogenesis with a Novel Anti-S100A4 Monoclonal Antibody

(2013) Jose Luis Hernández et al.   PLoS One

BCL2A1is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition

(2013) Rizwan Haq et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Promise of Patient-Derived Xenografts: The Best Laid Plans of Mice and Men

(2012) S. Kopetz et al.   CLINICAL CANCER RESEARCH

HMGA1 and HMGA2 protein expression correlates with advanced tumour grade and lymph node metastasis in pancreatic adenocarcinoma

(2012) Salvatore Piscuoglio et al.   HISTOPATHOLOGY

Tumor-initiating properties of breast cancer and melanoma cellsin vivoare not invariably reflected by spheroid formationin vitro, but can be increased by long-term culturing as adherent monolayers

(2012) Vanessa Kuch et al.   INTERNATIONAL JOURNAL OF CANCER

Expression of Microphthalmia-associated Transcription Factor (MITF), Which Is Critical for Melanoma Progression, Is Inhibited by Both Transcription Factor GLI2 and Transforming Growth Factor-β

(2012) Marie-Jeanne Pierrat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of SMURF2 Targeting on Susceptibility to MEK Inhibitors in Melanoma

(2012) Michael P. Smith et al.   JNCI-Journal of the National Cancer Institute

Plasticity of melanoma cells induced by neural cell crest conditions and three-dimensional growth

(2012) Stephanie Ghislin et al.   MELANOMA RESEARCH

Sphere formation and self-renewal capacity of melanoma cells is affected by the microenvironment

(2012) Malgorzata Sztiller-Sikorska et al.   MELANOMA RESEARCH

PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees

(2012) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

Beta-catenin inhibits melanocyte migration but induces melanoma metastasis

(2012) S J Gallagher et al.   ONCOGENE

TBX2 expression is regulated by PAX3 in the melanocyte lineage

(2012) Fang Liu et al.   Pigment Cell & Melanoma Research

Nonadhesive Culture System as a Model of Rapid Sphere Formation with Cancer Stem Cell Properties

(2012) Su-Feng Chen et al.   PLoS One

Sphere Culture of Murine Lung Cancer Cell Lines Are Enriched with Cancer Initiating Cells

(2012) Brian J. Morrison et al.   PLoS One

Wnt/ -Catenin Signaling and AXIN1 Regulate Apoptosis Triggered by Inhibition of the Mutant Kinase BRAFV600E in Human Melanoma

(2012) T. L. Biechele et al.   Science Signaling

Ras Stabilization Through Aberrant Activation of Wnt/ -Catenin Signaling Promotes Intestinal Tumorigenesis

(2012) W.-J. Jeong et al.   Science Signaling

ALDH1A Isozymes are Markers of Human Melanoma Stem Cells and Potential Therapeutic Targets

(2012) Yuchun Luo et al.   STEM CELLS

CTGF is overexpressed in malignant melanoma and promotes cell invasion and migration

(2011) S Braig et al.   BRITISH JOURNAL OF CANCER

Proinvasion Metastasis Drivers in Early-Stage Melanoma Are Oncogenes

(2011) Kenneth L. Scott et al.   CANCER CELL

β-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient Melanomas

(2011) William E. Damsky et al.   CANCER CELL

Serum Levels of Glycoprotein Dickkopf-1 in Patients with Cutaneous Malignant Melanoma: A Prospective Pilot Study

(2011) Robert Feldmann et al.   DERMATOLOGY

In melanoma, beta-catenin is a suppressor of invasion

(2011) I Arozarena et al.   ONCOGENE

Inverse expression states of the BRN2 and MITF transcription factors in melanoma spheres and tumour xenografts regulate the NOTCH pathway

(2011) A E Thurber et al.   ONCOGENE

Mitf is the key molecular switch between mouse or human melanoma initiating cells and their differentiated progeny

(2011) Y Cheli et al.   ONCOGENE

GLI2 and M-MITF transcription factors control exclusive gene expression programs and inversely regulate invasion in human melanoma cells

(2011) Delphine Javelaud et al.   Pigment Cell & Melanoma Research

The three M’s: melanoma, microphthalmia-associated transcription factor and microRNA

(2011) Rachel E. Bell et al.   Pigment Cell & Melanoma Research

Melanoma Spheroids Grown Under Neural Crest Cell Conditions Are Highly Plastic Migratory/Invasive Tumor Cells Endowed with Immunomodulator Function

(2011) Kiran Ramgolam et al.   PLoS One

β-Catenin Signaling Increases during Melanoma Progression and Promotes Tumor Cell Survival and Chemoresistance

(2011) Tobias Sinnberg et al.   PLoS One

Stem Cell Media Culture of Melanoma Results in the Induction of a Nonrepresentative Neural Expression Profile

(2011) Matthew Anaka et al.   STEM CELLS

Wnt/β-catenin Signaling in Normal and Cancer Stem Cells

(2011) Kenneth C. Valkenburg et al.   Cancers

Phenotypic Heterogeneity among Tumorigenic Melanoma Cells from Patients that Is Reversible and Not Hierarchically Organized

(2010) Elsa Quintana et al.   CANCER CELL

Wnt Inhibitor Dickkopf-1 as a Target for Passive Cancer Immunotherapy

(2010) N. Sato et al.   CANCER RESEARCH

Characterization of Melanoma Cells Capable of Propagating Tumors from a Single Cell

(2010) M. A. Held et al.   CANCER RESEARCH

An Integrated Approach to Uncover Drivers of Cancer

(2010) Uri David Akavia et al.   CELL

A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth

(2010) Alexander Roesch et al.   CELL

Multicellular tumor spheroids: An underestimated tool is catching up again

(2010) Franziska Hirschhaeuser et al.   JOURNAL OF BIOTECHNOLOGY

Heterogeneous Phenotype of Human Melanoma Cells with In Vitro and In Vivo Features of Tumor-Initiating Cells

(2010) Michela Perego et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cancer stem cells versus phenotype-switching in melanoma

(2010) Keith S. Hoek et al.   Pigment Cell & Melanoma Research

A Gene Expression Signature of Invasive Potential in Metastatic Melanoma Cells

(2009) Aaron R. Jeffs et al.   PLoS One

MDR1 expression identifies human melanoma stem cells

(2008) Gilmor I. Keshet et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel MITF targets identified using a two-step DNA microarray strategy

(2008) Keith S. Hoek et al.   Pigment Cell & Melanoma Research