Article
Immunology
Ruocong Zhao, Yuanbin Cui, Yongfang Zheng, Shanglin Li, Jiang Lv, Qiting Wu, Youguo Long, Suna Wang, Yao Yao, Wei Wei, Jie Yang, Bin-Chao Wang, Zhenfeng Zhang, Hui Zeng, Yangqiu Li, Peng Li
Summary: The expression of hyaluronic acid synthases (HAS) was found to be negatively correlated with patient survival in multiple types of solid tumors, hindering the anti-tumor activities of CAR-T cells. However, sPH20-IgG2 was shown to enhance the infiltration of CAR-T cells into tumors and improve their anti-tumor activity against solid tumors without affecting their cytotoxicity or cytokine secretion.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Monica Parodi, Simonetta Astigiano, Paolo Carrega, Gabriella Pietra, Chiara Vitale, Laura Damele, Melania Grottoli, Maria de la Luz Guevara Lopez, Riccardo Ferracini, Giulia Bertolini, Ilaria Roato, Massimo Vitale, Paola Orecchia
Summary: Since the first studies, mouse models have played a crucial role in understanding NK cells, their development, function, and behavior in normal and tumor tissues. Initially used to study murine NK cells, more sophisticated human-in-mice models have been developed to investigate human NK cells and minimize murine interference. This review provides an overview of the different models used to study NK cells, with a focus on the popular NOG and NSG models, which are used for human-in-mice tumor models, studying transferred human NK cells, and evaluating enhancers of human NK cell function.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Health Care Sciences & Services
Yu-Ning Lin, Ming-Yan Chen, Chun-Yi Tsai, Wen-Chi Chou, Jun-Te Hsu, Chun-Nan Yeh, Ta-Sen Yeh, Keng-Hao Liu
Summary: This study aimed to predict the diagnosis of gastric subepithelial tumors (GSETs) through a retrospective review. The results showed that age, hemoglobin levels, and computed tomography results can predict the risk of GISTs.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Jae-Il Choi, Sung Ill Jang, Jaehyun Hong, Chul Hoon Kim, Soon Sung Kwon, Joon Seong Park, Jong-Baeck Lim
Summary: In this study, it was demonstrated that CD44(+), CD24(+) and EpCAM(+) cancer-initiating cells (CICs) were enriched in patient-derived organoids of PDAC. CD44-expressing CICs formed lumen structures within the organoids. Additionally, CD44(-) cancer cells from the organoids could re-form organoids and be re-programed as CD44-expressing CICs. The study also showed that the maintenance of CICs in PDAC organoids was mediated by interactions with endothelial cells through Wnt and Notch signaling pathways.
Article
Health Care Sciences & Services
Melis Savasan Sogut, Chitra Venugopal, Basak Kandemir, Ugur Dag, Sujeivan Mahendram, Sheila Singh, Gizem Gulfidan, Kazim Yalcin Arga, Bayram Yilmaz, Isil Aksan Kurnaz
Summary: Elk-1, a member of the ETS domain superfamily, is a transcription factor involved in neuroprotection, neurodegeneration, and brain tumor proliferation. It regulates known targets like c-fos and egr-1, as well as SMN, SOD1, PSEN1, and CD133. Microarray analysis revealed Elk-1's significant regulation of genes related to nervous system development, pluripotency, and apoptosis. Elk-1 also plays a role in the self-renewal of CD133+ BTICs.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Anna Michel, Thiemo Florin Dinger, Ramazan Jabbarli, Philipp Dammann, Anne-Kathrin Uerschels, Marvin Darkwah Oppong, Neriman Oezkan, Andreas Junker, Ulrich Sure, Karsten Henning Wrede
Summary: Rosette-forming glioneuronal tumor (RGNT) is an extremely rare entity with no specific therapy guidelines. Surgical resection appears to be a feasible treatment option, and long-term MRI follow-up is crucial for monitoring tumor progression.
Review
Oncology
Joan Massague, Karuna Ganesh
Summary: Metastasis-initiating cells (MIC) are cancer cells with stem-like and immune-evasive properties that adopt regenerative progenitor phenotypes, enabling them to survive the stresses of metastasis and evade immune surveillance. Understanding the molecular mechanisms of MIC phenotypes and host tissue ecosystems is crucial for developing improved cancer therapeutics.
Article
Oncology
Martina K. Zowada, Stephan M. Tirier, Sebastian M. Dieter, Teresa G. Krieger, Ava Oberlack, Robert Lorenz Chua, Mario Huerta, Foo Wei Ten, Karin Laaber, Jeongbin Park, Katharina Jechow, Torsten Mueller, Mathias Kalxdorf, Mark Kriegsmann, Katharina Kriegsmann, Friederike Herbst, Jeroen Krijgsveld, Martin Schneider, Roland Eils, Hanno Glimm, Christian Conrad, Claudia R. Ball
Summary: Different cell types with tumor-initiating cell (TIC) activity in colorectal cancer (CRC) show distinct gene expression patterns at single-cell level. Metabolic states are closely linked to TIC activity in primary CRC cultures, suggesting oxidative phosphorylation as a potential target for novel therapies. Transcriptional heterogeneity at single-cell resolution identifies functional states during TIC differentiation and may reveal novel vulnerabilities in human CRC.
Article
Cell Biology
Yingai Shi, Guihua Liu, Rongpei Wu, David L. Mack, Xiuzhi Susan Sun, Joshua Maxwell, Xuan Guan, Anthony Atala, Yuanyuan Zhang
Summary: This study highlights the regenerative significance of telomerase activity in human primary USCs, showing that telomerase-positive USCs have a robust regenerative potential in cell proliferation and multipotent differentiation capacity. The presence of telomerase activity is associated with maintaining cell surface marker expression, chromosomal stability, and in vivo tumorigenic transformation in USCs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Shamin Li, Summer Zhuang, Antja Heit, Si-Lin Koo, Aaron C. Tan, I-Ting Chow, William W. Kwok, Iain Beehuat Tan, Daniel S. W. Tan, Yannick Simoni, Evan W. Newell
Summary: The study reveals the phenotypic heterogeneity of CD4(+) T cells in lung and colorectal cancers, which can also recognize cancer-unrelated antigens.
Article
Nutrition & Dietetics
Maelle Quere, Jean-Marc Alberto, Franck Broly, Sebastien Hergalant, Christo Christov, Guillaume Gauchotte, Jean-Louis Gueant, Fares Namour, Shyue-Fang Battaglia-Hsu
Summary: In this study, we successfully invalidated the ALDH1L2 gene using CRISPR-cas9 technique and found that the knockout of this gene rendered U251 glioblastoma cells methionine-independent in terms of cancer stem cell growth. We also observed higher levels of reactive oxygen radicals (ROS) and reduced total cellular NADPH in the knockout cells. The slower growth of the knockout tumor sphere may be related to its partial differentiation.
Article
Oncology
Jintao Guo, Qichao Ge, Fan Yang, Sheng Wang, Nan Ge, Xiang Liu, Jing Shi, Pietro Fusaroli, Yang Liu, Siyu Sun
Summary: This study investigated the mutational profile of small gastrointestinal stromal tumors (GISTs) and found a high overall mutation rate in small GISTs, indicating common genetic alterations in early GIST generation. The study also identified a high frequency of oncogenic BRAF-V600E mutations in small GISTs, which has not been previously reported.
Article
Oncology
Fang-Heng Zhu, Yang-Kun Wang, Jun-Ling Zhou, Nian-Long Meng, Yue Wang, Bo Jiang, Su-Nan Wang
Summary: The study investigated the histopathological types and distribution characteristics of gastric mixed tumors through analysis of 960 surgically resected samples. The most common histological type was epithelial-derived tumors, followed by tumors of different tissue origins, mesenchymal-derived tumors, neuroendocrine tumors, and lymphoma. The mixed histological patterns of gastric mixed tumors were divided into three types, with various gene mutations identified including HER2 gene amplification, K-ras, and PDGFRA.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Sara Rocha, Afonso P. Basto, Marieke E. Ijsselsteijn, Sara P. Teles, Maria M. Azevedo, Gilza Goncalves, Irene Gullo, Gabriela M. Almeida, Joaquin J. Maqueda, Marta Oliveira, Fatima Carneiro, Joao T. Barata, Luis Graca, Noel F. C. C. de Miranda, Joana Carvalho, Carla Oliveira
Summary: The role of regulatory T cells (Tregs) in gastric cancer (GC) remains controversial. Tregs may have a non-immunosuppressive effect on intestinal-type GC by inducing membrane expression of IL2R alpha and activating the MAPK signaling pathway, promoting spheroid growth in early stages of tumor development. This finding could lead to novel therapeutic strategies for intestinal-type GC and other tumors with similar immune context.
Article
Multidisciplinary Sciences
C. Megan Young, Laurent Beziaud, Pierre Dessen, Angela Madurga Alonso, Albert Santamaria-Martinez, Joerg Huelsken
Summary: This study examines the metabolic adaptations of metastasis-initiating cells (MICs) in female breast cancer and how those shape their metastatic phenotype. The findings demonstrate that MICs specifically alter their metabolism to efficiently colonize distant organs, and understanding these mechanisms may help control cancer progression.
NATURE COMMUNICATIONS
(2023)
Letter
Dermatology
Toshiyuki Yamamoto, Akiko Nishibu, Yoshinobu Eishi
JOURNAL OF DERMATOLOGY
(2017)
Article
Cell Biology
Shohei Tomii, Takumi Akashi, Noboru Ando, Tomoki Tamura, Akira Sakurai, Asami Terada, Asuka Furukawa, Yoshimi Suzuki, Kou Kayamori, Kei Sakamoto, Hironori Ishibashi, Yoshinobu Eishi
Article
Cell Biology
Nobuyasu Awano, Minoru Inomata, Soichiro Ikushima, Daisuke Yamada, Masatoshi Hotta, Shunji Tsukuda, Toshio Kumasaka, Tamiko Takemura, Yoshinobu Eishi
Article
Gastroenterology & Hepatology
Kiichiro Tsuchiya, Ryohei Hayashi, Keita Fukushima, Shuji Hibiya, Nobukatsu Horita, Mariko Negi, Eisaku Itoh, Takumi Akashi, Yoshinobu Eishi, Satoshi Motoya, Yoshiaki Takeuchi, Reiko Kunisaki, Ken Fukunaga, Shiro Nakamura, Naoki Yoshimura, Masakazu Takazoe, Bunei Iizuka, Yasuo Suzuki, Masakazu Nagahori, Mamoru Watanabe
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2017)
Article
Surgery
Mikito Inokuchi, Masatoshi Nakagawa, Toshiro Tanioka, Keisuke Okuno, Kentaro Gokita, Kazuyuki Kojima
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2018)
Article
Multidisciplinary Sciences
Tomoya Kakegawa, Yuan Bae, Takashi Ito, Keisuke Uchida, Masaki Sekine, Yutaka Nakajima, Asuka Furukawa, Yoshimi Suzuki, Jiro Kumagai, Takumi Akashi, Yoshinobu Eishi
Article
Oncology
Mikito Inokuchi, Hiraku Kumamaru, Masatoshi Nakagawa, Hiroaki Miyata, Yoshihiro Kakeji, Yasuyuki Seto, Kazuyuki Kojima
Article
Cell Biology
Katsumi Oishi, Takashi Ito, Daisuke Sakonishi, Keisuke Uchida, Masaki Sekine, Mariko Negi, Daisuke Kobayashi, Keiko Miura, Takumi Akashi, Yoshinobu Eishi
Review
Medicine, General & Internal
Tetsuo Yamaguchi, Ulrich Costabel, Andrew McDowell, Josune Guzman, Keisuke Uchida, Kenichi Ohashi, Yoshinobu Eishi
Summary: Sarcoidosis may have multiple causative agents, including infectious and non-infectious factors. Research suggests that Mycobacterium tuberculosis and Propionibacterium acnes are the most common microorganisms involved in the development of sarcoidosis. Differential diagnosis and treatment of sarcoidosis may involve immunohistochemistry with specific antibodies to distinguish cases caused by different etiologies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Microbiology
Takuma Isshiki, Sakae Homma, Yoshinobu Eishi, Matsuko Yabe, Kazuya Koyama, Yasuhiko Nishioka, Tetsuo Yamaguchi, Keisuke Uchida, Kurara Yamamoto, Kenichi Ohashi, Atsushi Arakawa, Kazutoshi Shibuya, Susumu Sakamoto, Kazuma Kishi
Summary: Propionibacterium acnes is associated with the pathogenesis of sarcoidosis. Immunohistochemistry with a PAB antibody can differentiate sarcoidosis from other granulomatous diseases by detecting P. acnes in granulomas. The automated Leica system has the best detection sensitivity for P. acnes in sarcoid granulomas.
Editorial Material
Gastroenterology & Hepatology
Takashi Ito, Yoshinobu Eishi, Daisuke Kobayashi, Takumi Akashi, Morio Koike, Kenichi Ohashi
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Agriculture, Dairy & Animal Science
Luciana Mandrioli, Victorio Codotto, Giulia D'Annunzio, Enrico Volpe, Francesca Errani, Yoshinobu Eishi, Keisuke Uchida, Maria Morini, Giuseppe Sarli, Sara Ciulli
Summary: Pathological and microbiological investigations were conducted on ornamental cichlids, revealing the potential presence of Cutibacterium acnes and Mycobacterium spp. in the fish, posing potential health risks to humans.
Article
Respiratory System
Els Beijer, Kees Seldenrijk, Yoshinobu Eishi, Keisuke Uchida, Jan Damen, Jan C. Grutters, Marcel Veltkamp
Summary: The study demonstrates the presence of Propionibacterium acnes in granulomas of Dutch sarcoidosis patients, with its frequency higher in patients with chronic disease requiring treatment. This suggests a potential benefit of antibiotic therapy for a subgroup of sarcoidosis patients.
Article
Respiratory System
Tsuyoshi Shirai, Haruhiko Furusawa, Asuka Furukawa, Yuki Ishige, Keisuke Uchida, Yasunari Miyazaki, Yoshinobu Eishi, Naohiko Inase
RESPIRATORY RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Jessica L. Werner, Sylvia G. Escolero, Jeff T. Hewlett, Tim N. Mak, Brian P. Williams, Yoshinobu Eishi, Gabriel Nunez
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2017)